Genomic Location: HiC_scaffold_1:5028659...5063340
NR annotation: XP_047140674.1, pregnancy zone protein-like [Hydra vulgaris]
Species Hydractinia symbiolongicarpus · all data for this species · gene families
| CDS |
| HSymV2.0_g01.00125_t1 |
| Transcript |
| HSymV2.0_g01.00125_t1 |
| Protein |
| HSymV2.0_g01.00125_t1 |
| UniProt accession | Description |
|---|---|
| Q63041 | Alpha-1-macroglobulin OS=Rattus norvegicus OX=10116 GN=A1m PE=1 SV=1 |
| Q61838 | Pregnancy zone protein OS=Mus musculus OX=10090 GN=Pzp PE=1 SV=3 |
| A8K2U0 | Alpha-2-macroglobulin-like protein 1 OS=Homo sapiens OX=9606 GN=A2ML1 PE=1 SV=3 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0000509 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF17791 all species → | MG3 | Macroglobulin domain MG3 | Domain | Interproscan |
| PF01835 all species → | MG2 | MG2 domain | Domain | Interproscan |
| PF07703 all species → | A2M_BRD | Alpha-2-macroglobulin bait region domain | Domain | Interproscan |
| PF07677 all species → | A2M_recep | A-macroglobulin receptor binding domain | Domain | Interproscan |
| PF00207 all species → | A2M | Alpha-2-macroglobulin family | Family | Interproscan |
| PF07678 all species → | TED_complement | A-macroglobulin TED domain | Repeat | Interproscan |
| PF17789 all species → | MG4 | Macroglobulin domain MG4 | Domain | Interproscan |
| PF17790 all species → | MG1 | Macroglobulin domain MG1 | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR013783 all species → | Homologous_superfamily | Immunoglobulin-like fold | Interproscan |
| IPR050473 all species → | Family | Alpha-2-macroglobulin/Complement system | Interproscan |
| IPR047565 all species → | Conserved_site | Alpha-macroglobulin-like, thiol-ester bond-forming region | Interproscan |
| IPR041555 all species → | Domain | Macroglobulin domain MG3 | Interproscan |
| IPR008930 all species → | Homologous_superfamily | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid | Interproscan |
| IPR002890 all species → | Domain | Macroglobulin domain | Interproscan |
| IPR011625 all species → | Domain | Alpha-2-macroglobulin, bait region domain | Interproscan |
| IPR001599 all species → | Domain | Alpha-2-macroglobulin | Interproscan |
| IPR019742 all species → | Conserved_site | Alpha-2-macroglobulin, conserved site | Interproscan |
| IPR041813 all species → | Domain | Alpha-2-macroglobulin, TED domain | Interproscan |
| IPR036595 all species → | Homologous_superfamily | Alpha-macroglobulin, receptor-binding domain superfamily | Interproscan |
| IPR009048 all species → | Domain | Alpha-macroglobulin, receptor-binding | Interproscan |
| IPR011626 all species → | Domain | Alpha-macroglobulin-like, TED domain | Interproscan |
| IPR014756 all species → | Homologous_superfamily | Immunoglobulin E-set | Interproscan |
| IPR040839 all species → | Domain | Macroglobulin domain MG4 | Interproscan |
| IPR041425 all species → | Domain | Complement C3/4/5, macroglobulin domain MG1 | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR11412 all species → | MACROGLOBULIN / COMPLEMENT | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0004866 all species → | Molecular Function | endopeptidase inhibitor activity | Interproscan |
| GO:0005576 all species → | Cellular Component | extracellular region | Interproscan |
| GO:0005615 all species → | Cellular Component | extracellular space | Interproscan |
HSymV2.0_g01.00125_t1.Transcript abundance of HSymV2.0_g01.00125_t1 across 44 RNA-seq samples of Hydractinia symbiolongicarpus. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| Whole embryo | 36 | 35 | 10.11 | 59.14 | |
| Whole embryo · Triptolide 20 uM | 4 | 3 | 1.80 | 3.10 | |
| Whole embryo · DMSO 0.5% | 4 | 4 | 7.99 | 12.06 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR24482157 | Whole embryo | Whole embryo | 48 hpf | not recorded | SRP436676 | 59.14 |
| SRR24482158 | Whole embryo | Whole embryo | 48 hpf | not recorded | SRP436676 | 38.75 |
| SRR24482156 | Whole embryo | Whole embryo | 72 hpf | not recorded | SRP436676 | 32.12 |
| SRR24482160 | Whole embryo | Whole embryo | 24 hpf | not recorded | SRP436676 | 31.88 |
| SRR24482155 | Whole embryo | Whole embryo | 72 hpf | not recorded | SRP436676 | 27.63 |
| SRR24482159 | Whole embryo | Whole embryo | 24 hpf | not recorded | SRP436676 | 26.43 |
| SRR24482153 | Whole embryo | Whole embryo | 7 hpf | not recorded | SRP436676 | 17.30 |
| SRR24482133 | Whole embryo | Whole embryo | 6 hpf | not recorded | SRP436676 | 13.96 |
| SRR24482162 | Whole embryo | Whole embryo | 7 hpf | not recorded | SRP436676 | 13.78 |
| SRR24482163 | Whole embryo | Whole embryo | 6 hpf | not recorded | SRP436676 | 9.48 |
| SRR24482161 | Whole embryo | Whole embryo | 7 hpf | not recorded | SRP436676 | 8.11 |
| SRR24482134 | Whole embryo | Whole embryo | 5 hpf | not recorded | SRP436676 | 6.17 |
| SRR24482136 | Whole embryo | Whole embryo | 4 hpf | not recorded | SRP436676 | 5.45 |
| SRR24482171 | Whole embryo | Whole embryo | 1 hpf | not recorded | SRP436676 | 4.39 |
| SRR24482174 | Whole embryo | Whole embryo | Unfertilized egg | not recorded | SRP436676 | 4.32 |
| SRR24482141 | Whole embryo | Whole embryo | 1 hpf | not recorded | SRP436676 | 4.30 |
| SRR24482175 | Whole embryo | Whole embryo | Unfertilized egg | not recorded | SRP436676 | 4.12 |
| SRR24482173 | Whole embryo | Whole embryo | Unfertilized egg | not recorded | SRP436676 | 4.09 |
| SRR24482138 | Whole embryo | Whole embryo | 3 hpf | not recorded | SRP436676 | 4.08 |
| SRR24482172 | Whole embryo | Whole embryo | 30 mpf | not recorded | SRP436676 | 3.93 |
| SRR24482170 | Whole embryo | Whole embryo | 2 hpf | not recorded | SRP436676 | 3.83 |
| SRR24482144 | Whole embryo | Whole embryo | Unfertilized egg | not recorded | SRP436676 | 3.75 |
| SRR24482145 | Whole embryo | Whole embryo | Unfertilized egg | not recorded | SRP436676 | 3.52 |
| SRR24482139 | Whole embryo | Whole embryo | 2 hpf | not recorded | SRP436676 | 3.28 |
| SRR24482168 | Whole embryo | Whole embryo | 3 hpf | not recorded | SRP436676 | 3.09 |
| SRR24482135 | Whole embryo | Whole embryo | 4 hpf | not recorded | SRP436676 | 3.07 |
| SRR24482140 | Whole embryo | Whole embryo | 2 hpf | not recorded | SRP436676 | 3.00 |
| SRR24482169 | Whole embryo | Whole embryo | 2 hpf | not recorded | SRP436676 | 2.96 |
| SRR24482143 | Whole embryo | Whole embryo | Unfertilized egg | not recorded | SRP436676 | 2.95 |
| SRR24482142 | Whole embryo | Whole embryo | 30 mpf | not recorded | SRP436676 | 2.87 |
| SRR24482166 | Whole embryo | Whole embryo | 4 hpf | not recorded | SRP436676 | 2.85 |
| SRR24482176 | Whole embryo | Whole embryo | 1 hpf | not recorded | SRP436676 | 2.80 |
| SRR24482137 | Whole embryo | Whole embryo | 3 hpf | not recorded | SRP436676 | 2.78 |
| SRR24482167 | Whole embryo | Whole embryo | 3 hpf | not recorded | SRP436676 | 2.14 |
| SRR24482165 | Whole embryo | Whole embryo | 4 hpf | not recorded | SRP436676 | 1.56 |
| SRR24482177 | Whole embryo | Whole embryo | 1 hpf | not recorded | SRP436676 | 0.00 |
| SRR24482150 | Whole embryo · Triptolide 20 uM | Whole embryo | 7 hpf | Triptolide 20 uM | SRP436676 | 3.10 |
| SRR24482149 | Whole embryo · Triptolide 20 uM | Whole embryo | 7 hpf | Triptolide 20 uM | SRP436676 | 2.71 |
| SRR24482147 | Whole embryo · Triptolide 20 uM | Whole embryo | 7 hpf | Triptolide 20 uM | SRP436676 | 1.38 |
| SRR24482146 | Whole embryo · Triptolide 20 uM | Whole embryo | 7 hpf | Triptolide 20 uM | SRP436676 | 0.00 |
| SRR24482151 | Whole embryo · DMSO 0.5% | Whole embryo | 7 hpf | DMSO 0.5% | SRP436676 | 12.06 |
| SRR24482152 | Whole embryo · DMSO 0.5% | Whole embryo | 7 hpf | DMSO 0.5% | SRP436676 | 7.59 |
| SRR24482148 | Whole embryo · DMSO 0.5% | Whole embryo | 7 hpf | DMSO 0.5% | SRP436676 | 6.60 |
| SRR24482154 | Whole embryo · DMSO 0.5% | Whole embryo | 7 hpf | DMSO 0.5% | SRP436676 | 5.72 |
Source: CnidoSite RNA-seq expression matrices (HSYMB_TPM,
StringTie quantification over 44 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Hydractinia symbiolongicarpus tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 12 | HSymV2.0_g06.10451_t1 | 0.958296401823688 |
| Negatively correlated | 6 | HSymV2.0_g14.23796_t1 | -0.91193840001144 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Hydractinia symbiolongicarpus, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
