Detailed information of HSymV2.0_g15.25593_t1 in Hydractinia symbiolongicarpus

Genomic Location: HiC_scaffold_15:10646631...10664780
NR annotation: XP_002162172.3, 26S proteasome non-ATPase regulatory subunit 2 [Hydra vulgaris]
Species Hydractinia symbiolongicarpus · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
Q5R9I626S proteasome non-ATPase regulatory subunit 2 OS=Pongo abelii OX=9601 GN=PSMD2 PE=2 SV=1
P5670126S proteasome non-ATPase regulatory subunit 2 OS=Bos taurus OX=9913 GN=PSMD2 PE=1 SV=2
Q1320026S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PSMD2 PE=1 SV=3
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0005285 (this species only) · gene tree & orthology

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF01851
all species →		PC_repProteasome/cyclosome repeatRepeatInterproscan
PF18051
all species →		RPN1_C26S proteasome non-ATPase regulatory subunit RPN1 C-terminalDomainInterproscan
PF17781
all species →		RPN1_RPN2_NRPN1 N-terminal domainDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR016643
all species →		Family26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunitInterproscan
IPR002015
all species →		RepeatProteasome/cyclosome repeatInterproscan
IPR011989
all species →		Homologous_superfamilyArmadillo-like helicalInterproscan
IPR016024
all species →		Homologous_superfamilyArmadillo-type foldInterproscan
IPR041433
all species →		Domain26S proteasome non-ATPase regulatory subunit RPN1, C-terminalInterproscan
IPR040892
all species →		DomainRPN1, N-terminalInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR10943
all species →		26S PROTEASOME NON-ATPASE REGULATORY SUBUNITInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0000502
all species →		Cellular Componentproteasome complexInterproscan
GO:0030234
all species →		Molecular Functionenzyme regulator activityInterproscan
GO:0042176
all species →		Biological Processregulation of protein catabolic processInterproscan
GO:0005634
all species →		Cellular ComponentnucleusInterproscan
GO:0008540
all species →		Cellular Componentproteasome regulatory particle, base subcomplexInterproscan
GO:0034515
all species →		Cellular Componentproteasome storage granuleInterproscan
GO:0043161
all species →		Biological Processproteasome-mediated ubiquitin-dependent protein catabolic processInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K03028PSMD2, RPN1; 26S proteasome regulatory subunit N1-Proteasomeko03051deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of HSymV2.0_g15.25593_t1 across 44 RNA-seq samples of Hydractinia symbiolongicarpus. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

44Samples
44TPM > 0
3Conditions
233.7Max TPM
180.5Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
Whole embryo 36 36 175.82 215.49
Whole embryo · Triptolide 20 uM 4 4 206.26 233.72
Whole embryo · DMSO 0.5% 4 4 196.76 213.23

Per sample · hover a bar for the full sample record

Show the sample table (44 samples)
SRA runConditionTissueDevelopmental stage TreatmentStudyTPM
SRR24482161 Whole embryo Whole embryo 7 hpf not recorded SRP436676 215.49
SRR24482172 Whole embryo Whole embryo 30 mpf not recorded SRP436676 215.30
SRR24482170 Whole embryo Whole embryo 2 hpf not recorded SRP436676 212.60
SRR24482171 Whole embryo Whole embryo 1 hpf not recorded SRP436676 207.87
SRR24482162 Whole embryo Whole embryo 7 hpf not recorded SRP436676 202.40
SRR24482159 Whole embryo Whole embryo 24 hpf not recorded SRP436676 199.20
SRR24482175 Whole embryo Whole embryo Unfertilized egg not recorded SRP436676 198.70
SRR24482168 Whole embryo Whole embryo 3 hpf not recorded SRP436676 198.52
SRR24482173 Whole embryo Whole embryo Unfertilized egg not recorded SRP436676 192.54
SRR24482160 Whole embryo Whole embryo 24 hpf not recorded SRP436676 192.11
SRR24482167 Whole embryo Whole embryo 3 hpf not recorded SRP436676 192.10
SRR24482153 Whole embryo Whole embryo 7 hpf not recorded SRP436676 192.07
SRR24482174 Whole embryo Whole embryo Unfertilized egg not recorded SRP436676 187.41
SRR24482169 Whole embryo Whole embryo 2 hpf not recorded SRP436676 185.73
SRR24482163 Whole embryo Whole embryo 6 hpf not recorded SRP436676 182.16
SRR24482141 Whole embryo Whole embryo 1 hpf not recorded SRP436676 182.05
SRR24482145 Whole embryo Whole embryo Unfertilized egg not recorded SRP436676 179.86
SRR24482157 Whole embryo Whole embryo 48 hpf not recorded SRP436676 178.97
SRR24482165 Whole embryo Whole embryo 4 hpf not recorded SRP436676 176.60
SRR24482156 Whole embryo Whole embryo 72 hpf not recorded SRP436676 176.27
SRR24482138 Whole embryo Whole embryo 3 hpf not recorded SRP436676 176.26
SRR24482140 Whole embryo Whole embryo 2 hpf not recorded SRP436676 174.06
SRR24482166 Whole embryo Whole embryo 4 hpf not recorded SRP436676 171.90
SRR24482134 Whole embryo Whole embryo 5 hpf not recorded SRP436676 171.49
SRR24482142 Whole embryo Whole embryo 30 mpf not recorded SRP436676 164.15
SRR24482136 Whole embryo Whole embryo 4 hpf not recorded SRP436676 163.32
SRR24482133 Whole embryo Whole embryo 6 hpf not recorded SRP436676 162.35
SRR24482158 Whole embryo Whole embryo 48 hpf not recorded SRP436676 161.88
SRR24482176 Whole embryo Whole embryo 1 hpf not recorded SRP436676 161.18
SRR24482143 Whole embryo Whole embryo Unfertilized egg not recorded SRP436676 160.34
SRR24482135 Whole embryo Whole embryo 4 hpf not recorded SRP436676 150.37
SRR24482144 Whole embryo Whole embryo Unfertilized egg not recorded SRP436676 141.46
SRR24482139 Whole embryo Whole embryo 2 hpf not recorded SRP436676 136.68
SRR24482137 Whole embryo Whole embryo 3 hpf not recorded SRP436676 131.49
SRR24482177 Whole embryo Whole embryo 1 hpf not recorded SRP436676 129.88
SRR24482155 Whole embryo Whole embryo 72 hpf not recorded SRP436676 104.66
SRR24482147 Whole embryo · Triptolide 20 uM Whole embryo 7 hpf Triptolide 20 uM SRP436676 233.72
SRR24482149 Whole embryo · Triptolide 20 uM Whole embryo 7 hpf Triptolide 20 uM SRP436676 203.63
SRR24482146 Whole embryo · Triptolide 20 uM Whole embryo 7 hpf Triptolide 20 uM SRP436676 195.18
SRR24482150 Whole embryo · Triptolide 20 uM Whole embryo 7 hpf Triptolide 20 uM SRP436676 192.51
SRR24482148 Whole embryo · DMSO 0.5% Whole embryo 7 hpf DMSO 0.5% SRP436676 213.23
SRR24482154 Whole embryo · DMSO 0.5% Whole embryo 7 hpf DMSO 0.5% SRP436676 210.12
SRR24482151 Whole embryo · DMSO 0.5% Whole embryo 7 hpf DMSO 0.5% SRP436676 184.45
SRR24482152 Whole embryo · DMSO 0.5% Whole embryo 7 hpf DMSO 0.5% SRP436676 179.23

Source: CnidoSite RNA-seq expression matrices (HSYMB_TPM, StringTie quantification over 44 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Hydractinia symbiolongicarpus tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

DirectionPartnersMost correlated partnerPCC
Positively correlated7HSymV2.0_g12.22092_t10.880341578451218
Negatively correlated17HSymV2.0_g06.10517_t1-0.732251456374861

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Hydractinia symbiolongicarpus, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.readyopen →
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
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