Detailed information of HSymV2.0_g15.25631_t1 in Hydractinia symbiolongicarpus

Genomic Location: HiC_scaffold_15:11067173...11082460
NR annotation: XP_047124631.1, centromere/kinetochore protein zw10 homolog [Hydra vulgaris]
Species Hydractinia symbiolongicarpus · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
Q5RFM4Centromere/kinetochore protein zw10 homolog OS=Pongo abelii OX=9601 GN=ZW10 PE=2 SV=3
O43264Centromere/kinetochore protein zw10 homolog OS=Homo sapiens OX=9606 GN=ZW10 PE=1 SV=3
Q4V8C2Centromere/kinetochore protein zw10 homolog OS=Rattus norvegicus OX=10116 GN=Zw10 PE=2 SV=3
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0005373 (this species only) · gene tree & orthology

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF20666
all species →		ZW10_CCentromere/kinetochore protein zw10, C-terminalRepeatInterproscan
PF20665
all species →		Zw10_middleCentromere/kinetochore protein zw10, middle domainRepeatInterproscan
PF06248
all species →		Zw10_NCentromere/kinetochore Zw10 N-terminalRepeatInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR048343
all species →		DomainCentromere/kinetochore protein zw10, C-terminal domainInterproscan
IPR046362
all species →		Homologous_superfamilyZw10/DSL1, C-terminalInterproscan
IPR048344
all species →		DomainCentromere/kinetochore protein zw10, middle domainInterproscan
IPR009361
all species →		DomainCentromere/kinetochore protein zw10, N-terminalInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR12205
all species →		CENTROMERE/KINETOCHORE PROTEIN ZW10Interproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0006888
all species →		Biological Processendoplasmic reticulum to Golgi vesicle-mediated transportInterproscan
GO:0007094
all species →		Biological Processmitotic spindle assembly checkpoint signalingInterproscan
GO:1990423
all species →		Cellular ComponentRZZ complexInterproscan
GO:0000278
all species →		Biological Processmitotic cell cycleInterproscan
GO:0000775
all species →		Cellular Componentchromosome, centromeric regionInterproscan
GO:0005634
all species →		Cellular ComponentnucleusInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K11578ZW10, DSL1; protein transport protein DSL1/ZW10-Chromosome and associated proteinsko03036deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of HSymV2.0_g15.25631_t1 across 44 RNA-seq samples of Hydractinia symbiolongicarpus. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

44Samples
44TPM > 0
3Conditions
85.6Max TPM
49.5Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
Whole embryo 36 36 51.29 85.55
Whole embryo · Triptolide 20 uM 4 4 48.36 57.86
Whole embryo · DMSO 0.5% 4 4 34.70 42.16

Per sample · hover a bar for the full sample record

Show the sample table (44 samples)
SRA runConditionTissueDevelopmental stage TreatmentStudyTPM
SRR24482139 Whole embryo Whole embryo 2 hpf not recorded SRP436676 85.55
SRR24482144 Whole embryo Whole embryo Unfertilized egg not recorded SRP436676 82.79
SRR24482137 Whole embryo Whole embryo 3 hpf not recorded SRP436676 81.17
SRR24482135 Whole embryo Whole embryo 4 hpf not recorded SRP436676 77.57
SRR24482143 Whole embryo Whole embryo Unfertilized egg not recorded SRP436676 76.85
SRR24482177 Whole embryo Whole embryo 1 hpf not recorded SRP436676 75.76
SRR24482134 Whole embryo Whole embryo 5 hpf not recorded SRP436676 71.65
SRR24482142 Whole embryo Whole embryo 30 mpf not recorded SRP436676 70.12
SRR24482141 Whole embryo Whole embryo 1 hpf not recorded SRP436676 68.33
SRR24482138 Whole embryo Whole embryo 3 hpf not recorded SRP436676 67.04
SRR24482136 Whole embryo Whole embryo 4 hpf not recorded SRP436676 66.94
SRR24482145 Whole embryo Whole embryo Unfertilized egg not recorded SRP436676 66.83
SRR24482140 Whole embryo Whole embryo 2 hpf not recorded SRP436676 65.03
SRR24482133 Whole embryo Whole embryo 6 hpf not recorded SRP436676 60.73
SRR24482166 Whole embryo Whole embryo 4 hpf not recorded SRP436676 54.03
SRR24482176 Whole embryo Whole embryo 1 hpf not recorded SRP436676 53.77
SRR24482167 Whole embryo Whole embryo 3 hpf not recorded SRP436676 53.22
SRR24482173 Whole embryo Whole embryo Unfertilized egg not recorded SRP436676 52.49
SRR24482165 Whole embryo Whole embryo 4 hpf not recorded SRP436676 52.18
SRR24482169 Whole embryo Whole embryo 2 hpf not recorded SRP436676 50.70
SRR24482174 Whole embryo Whole embryo Unfertilized egg not recorded SRP436676 49.65
SRR24482172 Whole embryo Whole embryo 30 mpf not recorded SRP436676 44.64
SRR24482171 Whole embryo Whole embryo 1 hpf not recorded SRP436676 43.43
SRR24482163 Whole embryo Whole embryo 6 hpf not recorded SRP436676 42.94
SRR24482168 Whole embryo Whole embryo 3 hpf not recorded SRP436676 42.81
SRR24482170 Whole embryo Whole embryo 2 hpf not recorded SRP436676 41.28
SRR24482162 Whole embryo Whole embryo 7 hpf not recorded SRP436676 39.90
SRR24482153 Whole embryo Whole embryo 7 hpf not recorded SRP436676 37.97
SRR24482175 Whole embryo Whole embryo Unfertilized egg not recorded SRP436676 32.12
SRR24482160 Whole embryo Whole embryo 24 hpf not recorded SRP436676 27.03
SRR24482161 Whole embryo Whole embryo 7 hpf not recorded SRP436676 25.20
SRR24482159 Whole embryo Whole embryo 24 hpf not recorded SRP436676 23.97
SRR24482157 Whole embryo Whole embryo 48 hpf not recorded SRP436676 18.79
SRR24482156 Whole embryo Whole embryo 72 hpf not recorded SRP436676 16.05
SRR24482155 Whole embryo Whole embryo 72 hpf not recorded SRP436676 14.29
SRR24482158 Whole embryo Whole embryo 48 hpf not recorded SRP436676 13.66
SRR24482149 Whole embryo · Triptolide 20 uM Whole embryo 7 hpf Triptolide 20 uM SRP436676 57.86
SRR24482150 Whole embryo · Triptolide 20 uM Whole embryo 7 hpf Triptolide 20 uM SRP436676 57.24
SRR24482146 Whole embryo · Triptolide 20 uM Whole embryo 7 hpf Triptolide 20 uM SRP436676 40.30
SRR24482147 Whole embryo · Triptolide 20 uM Whole embryo 7 hpf Triptolide 20 uM SRP436676 38.01
SRR24482152 Whole embryo · DMSO 0.5% Whole embryo 7 hpf DMSO 0.5% SRP436676 42.16
SRR24482151 Whole embryo · DMSO 0.5% Whole embryo 7 hpf DMSO 0.5% SRP436676 38.58
SRR24482154 Whole embryo · DMSO 0.5% Whole embryo 7 hpf DMSO 0.5% SRP436676 30.08
SRR24482148 Whole embryo · DMSO 0.5% Whole embryo 7 hpf DMSO 0.5% SRP436676 27.99

Source: CnidoSite RNA-seq expression matrices (HSYMB_TPM, StringTie quantification over 44 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Hydractinia symbiolongicarpus tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

DirectionPartnersMost correlated partnerPCC
Positively correlated28HSymV2.0_g05.09620_t10.965481488690797
Negatively correlated5HSymV2.0_g08.13717_t1-0.929577570010906

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Hydractinia symbiolongicarpus, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.readyopen →
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
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