Gene detail

Detailed information of KXJ04451.1 in Exaiptasia diaphana

Genomic Location: LJWW01003844.1:128...1136
NR annotation: KXJ04451.1, 5,10-methylenetetrahydrofolate reductase, partial [Exaiptasia diaphana]
Species Exaiptasia diaphana · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
O67422	5,10-methylenetetrahydrofolate reductase OS=Aquifex aeolicus (strain VF5) OX=224324 GN=metF PE=3 SV=1
P42898	Methylenetetrahydrofolate reductase (NADPH) OS=Homo sapiens OX=9606 GN=MTHFR PE=1 SV=3
Q5I598	Methylenetetrahydrofolate reductase (NADPH) OS=Bos taurus OX=9913 GN=MTHFR PE=2 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0024274 (this species only)

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF02219 all species →	MTHFR	Methylenetetrahydrofolate reductase	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR003171 all species →	Family	Methylenetetrahydrofolate reductase-like	Interproscan
IPR029041 all species →	Homologous_superfamily	FAD-linked oxidoreductase-like	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR45754 all species →	METHYLENETETRAHYDROFOLATE REDUCTASE	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0004489 all species →	Molecular Function	methylenetetrahydrofolate reductase (NAD(P)H) activity	Interproscan
GO:0006555 all species →	Biological Process	methionine metabolic process	Interproscan
GO:0005829 all species →	Cellular Component	cytosol	Interproscan
GO:0009086 all species →	Biological Process	methionine biosynthetic process	Interproscan
GO:0035999 all species →	Biological Process	tetrahydrofolate interconversion	Interproscan
GO:0071949 all species →	Molecular Function	FAD binding	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K00297	metF, MTHFR; methylenetetrahydrofolate reductase (NADH)	EC:1.5.1.54	One carbon pool by folate	ko00670	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.