Gene detail

Detailed information of KXJ16622.1 in Exaiptasia diaphana

Genomic Location: LJWW01000192.1:168896...174989
NR annotation: XP_020896365.1, folliculin [Exaiptasia diaphana]
Species Exaiptasia diaphana · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q5M7Q1	Folliculin OS=Xenopus tropicalis OX=8364 GN=flcn PE=2 SV=1
Q8NFG4	Folliculin OS=Homo sapiens OX=9606 GN=FLCN PE=1 SV=1
Q8QZS3	Folliculin OS=Mus musculus OX=10090 GN=Flcn PE=1 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0004906 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF16692 all species →	Folliculin_C	Folliculin C-terminal domain	Domain	Interproscan
PF11704 all species →	Folliculin	Vesicle coat protein involved in Golgi to plasma membrane transport	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR037521 all species →	Domain	Folliculin/SMCR8, tripartite DENN domain	Interproscan
IPR032035 all species →	Domain	Folliculin, DENN domain	Interproscan
IPR037520 all species →	Domain	Folliculin/SMCR8, longin domain	Interproscan
IPR021713 all species →	Family	Folliculin	Interproscan
IPR044886 all species →	Homologous_superfamily	Folliculin, DENN domain, C-terminal superfamily	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR31441 all species →	FOLLICULIN FAMILY MEMBER	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005096 all species →	Molecular Function	GTPase activator activity	Interproscan
GO:0000122 all species →	Biological Process	negative regulation of transcription by RNA polymerase II	Interproscan
GO:0005829 all species →	Cellular Component	cytosol	Interproscan
GO:0030511 all species →	Biological Process	positive regulation of transforming growth factor beta receptor signaling pathway	Interproscan
GO:1904263 all species →	Biological Process	positive regulation of TORC1 signaling	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K09594	FLCN, BHD; folliculin	-	Renal cell carcinoma	ko05211	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of KXJ16622.1 across 72 RNA-seq samples of Exaiptasia diaphana. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

72Samples

64TPM > 0

2Conditions

28.5Max TPM

17.3Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM	Mean, relative to max
whole animal · aposymbiotic	36	33	16.80	26.45
whole animal · symbiotic	36	31	17.70	28.55

Per sample · hover a bar for the full sample record · show / hide the sample table

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR6202363	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	26.45
SRR6202258	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	25.68
SRR6202206	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	24.26
SRR6202210	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	23.72
SRR6202235	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	22.13
SRR6202256	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	21.81
SRR6202254	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	21.64
SRR6202208	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	21.50
SRR6202343	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	21.21
SRR6202207	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	20.52
SRR6202237	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	19.90
SRR6202209	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	19.26
SRR6202233	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	18.55
SRR6202203	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	18.55
SRR6202344	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	18.53
SRR6202241	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	18.32
SRR6202255	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	18.27
SRR6202204	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	18.22
SRR6202238	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	17.72
SRR6202236	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	17.44
SRR6202242	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	17.07
SRR6202346	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	16.95
SRR6202260	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	16.35
SRR6202240	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	16.25
SRR6202234	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	16.16
SRR6202205	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	15.99
SRR6202257	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	15.93
SRR6202239	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	15.03
SRR6202261	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	14.89
SRR6202211	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	13.72
SRR6202212	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	12.99
SRR6202259	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	11.07
SRR6202358	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	8.74
SRR6202345	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	0.00
SRR6202357	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	0.00
SRR6202364	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	0.00
SRR6202309	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	28.55
SRR6202285	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	26.74
SRR6202277	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	24.96
SRR6202280	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	24.04
SRR6202262	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	23.88
SRR6202263	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	23.85
SRR6202281	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	23.80
SRR6202341	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	23.77
SRR6202340	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	22.98
SRR6202337	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	21.88
SRR6202305	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	21.65
SRR6202310	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	21.32
SRR6202276	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	21.25
SRR6202347	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	21.24
SRR6202339	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	20.70
SRR6202283	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	20.28
SRR6202307	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	20.18
SRR6202306	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	19.94
SRR6202279	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	19.81
SRR6202303	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	19.42
SRR6202282	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	19.31
SRR6202355	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	19.19
SRR6202278	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	18.83
SRR6202308	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	18.44
SRR6202352	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	17.92
SRR6202351	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	17.77
SRR6202338	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	17.64
SRR6202284	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	16.89
SRR6202304	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	15.71
SRR6202356	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	12.93
SRR6202350	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	12.45
SRR6202342	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	0.00
SRR6202348	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	0.00
SRR6202349	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	0.00
SRR6202353	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	0.00
SRR6202354	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	0.00

Source: CnidoSite RNA-seq expression matrices (EDIAP_TPM, StringTie quantification over 72 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.