Gene detail

Detailed information of KXJ27186.1 in Exaiptasia diaphana

Genomic Location: LJWW01000022.1:847593...865205
NR annotation: XP_020898469.1, phosphoinositide 3-kinase regulatory subunit 4 isoform X2 [Exaiptasia diaphana]
Species Exaiptasia diaphana · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

KXJ27186.1

ATGGGTAACCAGCTAACAGGAATTGCCCCATCACAGATCCTCAGCGTCGATCACTACTTCACCGATTTGCCAGATTACGAGTTTGATGGAAGTTTGGGAAGTACAAGGTTCTTCAAAGTTGCACGTGCACGTCATAGGGAAGGACTATGTGTTGTCAAAGTGTTTGCGATCCAAGATCCATCTCTGCCTCTTAAAACATACCAGGATGAACTGAAAGACATCAATATTAGACTAGCAAATGCGCCAAATGTGCTGCCATTTCAGAGATCCATTCTCACAGACAAAGCAAGCCTACTTCTACGACAGTTTGTCAAAGATAACTTGTATGACAGGATAAGTACCAGGCCATTTTTAAACCTCATAGAAAARAAATGGATAGTTTACCAGCTGTTATGTGCCTTAGAACAATGCCATTCAGTAAAAGTTTGTCAYGGAGATATCAAAACTGAGAACATCATGGTCACAAGTTGGAACTGGGTTCTTCTTACTGACATAGCAAGCTTCAAGCCAGCGTACCTSCCAGAAGACAATCCATCCGACTTCACCTTCTTCTTTGATACATCTCGTAGACGGACATGTTACATTGCTCCTGAGAGGTTTTTAGACTCAAGACAATCAGATGCTTTCATGGCTAGTGGAGTTTCARTAGATTCACAATCTATTGGTGGACCAAGCTTACCAAATATGGATTTATTACAAAGACAAAAGGGAGAGCTACAACCTGCAATGGATATTTTTTCTTTAGGATGTGTGATTGCTGAGCTTTTTAGTGAAGGCAATAAACTCTTTGATTTGTCAGAACTTTTAGCATACAAAAAGGGAGAGTATGACCCCAGGCCATCATTAGAGAAGATTGAAGATAATCAAATTAGGGAAATGGTTGAGCACATGATTTCTAAGGATCCATCTAAACGTCTGATTGCTTCTGAGTACTTGAGGAACTATGGAGGGTCTGTTTTTCCTGAGCAGTTCCATAGATTTCTAGAAACCTACATGACAAGATTTGCCACTTTACCAGTTTTGACTTCGGATGAAAAAATAACCAGATTGAAAAGAGATATTGATAATATTCTAAATGAACTTTTGCCTGTTGGAGAAAATAATTCGAAACCTGTCAAAGATAAAGATGGGTGCCTTGTGATTATAGTCTCATTATTAACAACCTGYGTGCGTACCTGTAAGTACTGCGTCTCTAAACTGACAGCCTTGGAGCTTATGTTAACRCTGGCCCAGCATGTGAACGATGACATTATTCTTGAAAGATTACTACCATATATGCTKTACATGGTSAATGATGCGCTGCCGCAAGTACGAGCTCAGGCACTTAAAACAYTAACACAGTGCTTGCATCTTGTGAAGAACATTGCAAGAAGTGATGCAAATATTTTCCCTGAATACATTTTGCCAAGTATAACATGGCTTACCCAAGATGAAGAAGTTATAGTTMGACTTGCATATGCTGAGAGTATTGCATCATTAGCAGAAACAGCTCTTAAATTCCTAGAAATGGCGCARCTRGAYCGTAGTAAYATYAACAAAGGAAGCCAGGAAGATACACCAATACAGTATCAAGGGAGTTATGATTCAGAGCTGCAAGCCTTACACAAGATAATTCAAGGMAAAGTTGTCACTCTCCTTAGTGACCAAGAAAACATTGTAAAAAGAACATTATTAGAAAATGGCATCACCAGGCTATGTGTATTTTTTGGTCGACAAAAAGCAAATGATGTGCTCTTGTCWCATATGATAACATTTTTAAATGATAAATATGACTGGCAGYTACGTGGAGCTTTCTTTGATAGCATTGTTGGAATTGCAGCTTATGTAGGTTGGCARAGTTTAGCCATGCTTCGTCCTCTTTTGGAACAGGGTTTGAGTGACACAGAGGAGTTTGTTGTGTGTAAAGCCTTACATGCCTTAACGTGTCTGGCAGAGCTTGGTCTTCTACCAAAACCAACATTACATGAGCTTGTTTCTGAGATTGTACCTTTCCTTTGTCATCCTGATATGTGGGTCAGATATGGTTCTGTAGGGTTTGTAGCAGCYGTGGCGAGAACTCTTAATGTTGCTGATGTCCACTGTAATCTACTCCCATTGCTTCAGCCATTTCTTAAACAGCCTGTCATTCAAGTTGAACAAGAGGTTATTCTTGTAAGTTTGCTGAAGGAACCGATCAATAGAGCTGTCTATGATTTTATCATAAAGTCACCTCATATCAACACMTTATTTGAAAGCTTACAAGACCGTCAAYTAAGGCGCAATGTCTGTAGAAGTGGTCAAAGGCCAACATATTCAGAAACAGAAGAAGTACTTGTTCCCGTGTATCGAAAGCTTCATTCACAAGGAGTAACAGAAGCAGATGAAGATAAGTTGCTCTACTTGAAGGATATCATGTTAAAACTTCACCATGCCAAGRCCAGTAATTTAGATCAGCCAGACAAGACTGACACCAACATCAGTGGCGAGATGGACCTCAAGTTGTACTCTAAGTCTGTGTTAAGAAGACATGCTGATTTAGCCAAGTCAGGTGAAGGCAAATCTGATAATAGTGGAAACAAAAAGGGTACATCGAAGAACAAGAAACAGTTAGCAGAACAACAAATGAATCCTGAATGGCATCAGATATTTGGCTTTACAGAACCCAGCACAATGAACAAAAAAGATGCAACACTTCCAGCACAGACCCAGTCAAGACCTAAGTCTCCACTWAAAAARACAGTCTCTGTACCAGTCCCACAGCCTTCATTTGAACCACCCGAGCGTCCTCGTAGTCCTTCTGGTTCACTACCCATATCAGGGACCCAGCGACCAGATTCAACAGCCTCTCTTTCAAGACCTTCCTCAATACAATCATCCATGAGTTCMCTTGATGTGTCCCAGAATTCTGTGCAAGCAAGGTTTGCTGAGTGCAARCTTGACCTACGGAAACTTGTTCATCATAAAAGGGATCTGTTTGCTGCTGATATGAAAGAGAAAGACATTATTGGAAGTGTTTTATCAAAAGGTAGAAAGCCARTACAACAAAGATGGTCTCCTAAAGGACTACTTGTAGCTCATTTACATGAGCACAAGGCTGCAATAAACAGAATTCAGCTAAGTCAAGATGCCCAGTATTTTGCCACAGCATCAGATGATGGTTCAGTCAAACTYTGGGACTTACAAAAATTGGATGGAAAAAGTTTGATAAATAAGTCACGTCAGACWTACAGTCGGCATGGTTGTAAGATTAAAGCAGTTCTGTTCTGTCAGAATTCCATTGCATGTGCATCAGACGAGGGAATCCTCAATGTATTTGGGATAGAACAAAGCYTACAGCAGTCTTCAGTGTCAAAGGTACAGATCTATGAGAAGAGAGTCAGTTCATCCAATGAAGGCTCCATTGTGGATATGGCTCACTTTGATACAGGTTCACAGTCTGTTCTAACTTACGCCACATCACATGGGTTTGTTTGTGGCTGGGATTTACGYTCAGCAACRATGGCYTGGAAACTAGTCAATGATCCATCAAAAGGTCTAATTACTTCGTTTGTTGTGGATCCATGTCATTGCTGGCTTGTTGTTGGTACGTCAACTGGTAATATGGTCTGTTGGGATYTACGTTTTCAGCTGCCTATCACAAGTCTGGTTCATCCAACAGGTGCAAGGATCCGTCGACTAGCAACACACCCAGTAGAACAGTCATGGGTTGTTTCGGCCGTACAAGGCAACAATGAAGTCAATATCTGGGATCTAGAAACTGGTTCAAGAAGRCAGACATTATGGGCCAGCAACACTCCACCATTATCTCAAACCCAGGTCTCYCCTCATGCAATCCATGCCGTTTATTCCAGTCTCCCAGATACAAGCCCGTACATCATAACAGCAGGCTCAGATAGGAGGATAAGGCTKTGGGATATAGCATTCCCTGAACACTCTCAGATGGTGGCTGGAGCTGCTACAGATAATTTGAACAACGTTGTACTTCAATACAAGTCCAGACTGATTGATGGAACTGAAGTTTTTCAAGAAATTTACTGTAAGCCTCGCCAGGGTACTGTACAAGAAGACATGCCAAGGAGAGGTCCRGAGCAACCCTCAGTCGGCCATCATGAATGCATAAATGACTTAATAGTATCCAAATCACCACAAAATTTCATAGTTACAGCAGGAAGAGATGGAGTAGTGAAAATATGGAAATGA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q99570	Phosphoinositide 3-kinase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PIK3R4 PE=1 SV=3
Q5R9I3	Phosphoinositide 3-kinase regulatory subunit 4 OS=Pongo abelii OX=9601 GN=PIK3R4 PE=2 SV=3
Q8VD65	Phosphoinositide 3-kinase regulatory subunit 4 OS=Mus musculus OX=10090 GN=Pik3r4 PE=1 SV=3

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0001260 (this species only)
Ubiquitin family	UBD\|Other\|Beta-prp · all ubiquitin genes in this species
Ubiquitin family	E3\|E3 adaptor Cullin RING\|CDC20 · all ubiquitin genes in this species
Ubiquitin family	E3\|E3 adaptor Cullin RING\|DWD · all ubiquitin genes in this species

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF00069 all species →	Pkinase	Protein kinase domain	Domain	Interproscan
PF00400 all species →	WD40	WD domain, G-beta repeat	Repeat	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR001680 all species →	Repeat	WD40 repeat	Interproscan
IPR019775 all species →	Conserved_site	WD40 repeat, conserved site	Interproscan
IPR011989 all species →	Homologous_superfamily	Armadillo-like helical	Interproscan
IPR000719 all species →	Domain	Protein kinase domain	Interproscan
IPR015943 all species →	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	Interproscan
IPR021133 all species →	Repeat	HEAT, type 2	Interproscan
IPR036322 all species →	Homologous_superfamily	WD40-repeat-containing domain superfamily	Interproscan
IPR016024 all species →	Homologous_superfamily	Armadillo-type fold	Interproscan
IPR020472 all species →	Repeat	G-protein beta WD-40 repeat	Interproscan
IPR008271 all species →	Active_site	Serine/threonine-protein kinase, active site	Interproscan
IPR045162 all species →	Family	Serine/threonine-protein kinase Vps15-like	Interproscan
IPR011009 all species →	Homologous_superfamily	Protein kinase-like domain superfamily	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR17583 all species →	PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005515 all species →	Molecular Function	protein binding	Interproscan
GO:0004672 all species →	Molecular Function	protein kinase activity	Interproscan
GO:0005524 all species →	Molecular Function	ATP binding	Interproscan
GO:0006468 all species →	Biological Process	protein phosphorylation	Interproscan
GO:0004674 all species →	Molecular Function	protein serine/threonine kinase activity	Interproscan
GO:0005770 all species →	Cellular Component	late endosome	Interproscan
GO:0006623 all species →	Biological Process	protein targeting to vacuole	Interproscan
GO:0016236 all species →	Biological Process	macroautophagy	Interproscan
GO:0030242 all species →	Biological Process	autophagy of peroxisome	Interproscan
GO:0034271 all species →	Cellular Component	phosphatidylinositol 3-kinase complex, class III, type I	Interproscan
GO:0034272 all species →	Cellular Component	phosphatidylinositol 3-kinase complex, class III, type II	Interproscan
GO:0045324 all species →	Biological Process	late endosome to vacuole transport	Interproscan
GO:0071561 all species →	Cellular Component	nucleus-vacuole junction	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K08333	PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4	EC:2.7.11.1	Membrane trafficking	ko04131	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of KXJ27186.1 across 72 RNA-seq samples of Exaiptasia diaphana. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

72Samples

70TPM > 0

2Conditions

42.4Max TPM

21.6Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM	Mean, relative to max
whole animal · aposymbiotic	36	35	19.08	42.37
whole animal · symbiotic	36	35	24.14	39.85

Per sample · hover a bar for the full sample record · show / hide the sample table

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR6202357	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	42.37
SRR6202344	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	31.68
SRR6202345	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	30.93
SRR6202343	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	29.78
SRR6202260	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	25.66
SRR6202261	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	24.84
SRR6202241	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	23.86
SRR6202233	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	23.62
SRR6202242	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	22.87
SRR6202259	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	22.14
SRR6202258	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	21.90
SRR6202234	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	20.60
SRR6202358	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	20.41
SRR6202209	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	20.40
SRR6202212	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	19.82
SRR6202346	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	19.22
SRR6202211	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	18.90
SRR6202363	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	18.87
SRR6202210	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	18.41
SRR6202207	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	17.12
SRR6202205	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	16.49
SRR6202235	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	15.96
SRR6202208	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	15.87
SRR6202255	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	15.49
SRR6202237	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	15.27
SRR6202236	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	14.91
SRR6202206	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	14.84
SRR6202256	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	14.25
SRR6202254	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	14.16
SRR6202239	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	13.80
SRR6202238	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	13.31
SRR6202203	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	12.95
SRR6202257	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	12.49
SRR6202204	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	12.44
SRR6202240	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	11.26
SRR6202364	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	0.00
SRR6202342	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	39.85
SRR6202306	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	34.71
SRR6202304	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	33.42
SRR6202349	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	32.67
SRR6202284	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	31.95
SRR6202303	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	31.06
SRR6202285	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	30.90
SRR6202283	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	30.09
SRR6202307	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	29.21
SRR6202305	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	28.42
SRR6202282	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	28.24
SRR6202354	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	27.95
SRR6202310	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	26.42
SRR6202309	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	25.87
SRR6202339	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	25.69
SRR6202308	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	24.79
SRR6202341	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	24.44
SRR6202340	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	24.23
SRR6202263	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	23.45
SRR6202347	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	23.25
SRR6202262	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	22.33
SRR6202348	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	21.05
SRR6202352	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	20.59
SRR6202355	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	20.44
SRR6202338	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	20.30
SRR6202276	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	20.17
SRR6202281	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	19.82
SRR6202279	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	19.74
SRR6202277	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	19.63
SRR6202337	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	19.62
SRR6202280	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	18.76
SRR6202351	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	18.45
SRR6202278	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	18.42
SRR6202350	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	16.84
SRR6202356	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	16.17
SRR6202353	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	0.00

Source: CnidoSite RNA-seq expression matrices (EDIAP_TPM, StringTie quantification over 72 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.