Gene detail

Detailed information of KXJ27229.1 in Exaiptasia diaphana

Genomic Location: LJWW01000022.1:910895...918318
NR annotation: XP_020898439.1, F-actin-capping protein subunit beta isoform X1 [Exaiptasia diaphana]
Species Exaiptasia diaphana · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
P47756	F-actin-capping protein subunit beta OS=Homo sapiens OX=9606 GN=CAPZB PE=1 SV=5
A0PFK7	F-actin-capping protein subunit beta OS=Sus scrofa OX=9823 GN=CAPZB PE=1 SV=2
Q5R507	F-actin-capping protein subunit beta OS=Pongo abelii OX=9601 GN=CAPZB PE=2 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0007378 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF01115 all species →	F_actin_cap_B	F-actin capping protein, beta subunit	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR043175 all species →	Homologous_superfamily	F-actin-capping protein subunit beta, N-terminal domain	Interproscan
IPR019771 all species →	Conserved_site	F-actin capping protein, beta subunit, conserved site	Interproscan
IPR037282 all species →	Homologous_superfamily	F-actin-capping protein subunit alpha/beta	Interproscan
IPR001698 all species →	Family	F-actin-capping protein subunit beta	Interproscan
IPR042276 all species →	Homologous_superfamily	F-actin-capping protein subunit alpha/beta, domain 2	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR10619 all species →	F-ACTIN-CAPPING PROTEIN SUBUNIT BETA	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0003779 all species →	Molecular Function	actin binding	Interproscan
GO:0005737 all species →	Cellular Component	cytoplasm	Interproscan
GO:0008290 all species →	Cellular Component	F-actin capping protein complex	Interproscan
GO:0030036 all species →	Biological Process	actin cytoskeleton organization	Interproscan
GO:0051016 all species →	Biological Process	barbed-end actin filament capping	Interproscan
GO:0000902 all species →	Biological Process	cell morphogenesis	Interproscan
GO:0010591 all species →	Biological Process	regulation of lamellipodium assembly	Interproscan
GO:0051015 all species →	Molecular Function	actin filament binding	Interproscan
GO:0051490 all species →	Biological Process	negative regulation of filopodium assembly	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K10365	CAPZB; F-actin-capping protein subunit beta	-	Exosome	ko04147	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of KXJ27229.1 across 72 RNA-seq samples of Exaiptasia diaphana. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

72Samples

72TPM > 0

2Conditions

337.5Max TPM

189.4Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM	Mean, relative to max
whole animal · aposymbiotic	36	36	164.08	248.60
whole animal · symbiotic	36	36	214.63	337.51

Per sample · hover a bar for the full sample record

Show the sample table (72 samples)

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR6202364	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	248.60
SRR6202357	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	215.79
SRR6202204	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	191.69
SRR6202239	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	184.70
SRR6202240	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	179.64
SRR6202257	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	177.30
SRR6202256	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	176.49
SRR6202203	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	173.57
SRR6202344	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	170.43
SRR6202209	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	166.71
SRR6202255	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	166.07
SRR6202242	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	164.21
SRR6202207	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	162.70
SRR6202238	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	162.33
SRR6202261	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	162.08
SRR6202254	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	161.48
SRR6202235	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	160.89
SRR6202212	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	160.09
SRR6202236	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	160.06
SRR6202260	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	159.76
SRR6202211	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	158.93
SRR6202345	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	156.74
SRR6202234	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	156.18
SRR6202205	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	154.39
SRR6202210	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	154.20
SRR6202241	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	153.08
SRR6202237	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	152.74
SRR6202233	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	149.44
SRR6202208	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	149.20
SRR6202259	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	148.98
SRR6202363	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	147.47
SRR6202258	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	147.04
SRR6202206	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	145.82
SRR6202358	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	145.06
SRR6202343	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	141.84
SRR6202346	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	141.05
SRR6202348	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	337.51
SRR6202342	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	296.42
SRR6202351	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	270.19
SRR6202280	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	266.33
SRR6202281	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	266.09
SRR6202352	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	262.18
SRR6202353	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	253.79
SRR6202347	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	252.24
SRR6202356	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	236.95
SRR6202350	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	228.81
SRR6202337	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	226.20
SRR6202278	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	215.40
SRR6202354	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	215.11
SRR6202277	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	213.80
SRR6202276	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	212.72
SRR6202338	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	208.01
SRR6202355	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	205.32
SRR6202306	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	204.84
SRR6202279	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	204.31
SRR6202283	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	197.19
SRR6202341	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	197.16
SRR6202262	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	195.31
SRR6202309	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	194.79
SRR6202307	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	192.41
SRR6202310	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	191.37
SRR6202308	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	189.08
SRR6202305	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	187.77
SRR6202285	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	186.84
SRR6202339	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	186.28
SRR6202340	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	185.15
SRR6202263	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	184.19
SRR6202282	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	182.25
SRR6202304	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	181.44
SRR6202284	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	173.34
SRR6202303	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	168.90
SRR6202349	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	156.85

Source: CnidoSite RNA-seq expression matrices (EDIAP_TPM, StringTie quantification over 72 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Exaiptasia diaphana tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

Direction	Partners	Most correlated partner	PCC
Positively correlated	31	KXJ26213.1	0.852203737788365
Negatively correlated	50	KXJ21068.1	-0.74686988645888

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Exaiptasia diaphana, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

Peak calls overlapping this gene

Assay	Sample	Peaks	Region
ChIP-seq	H3K27ac_symbiont	1	Promoter (<=1kb) 1
	H3K9ac_symbiont	1	Promoter (<=1kb) 1

Browse the full epigenomic landscape of this species: ChIP-seq · ATAC-seq.

DNA methylation (bisulphite samples)

Sample	Methylation profile
whole_animal_aposymbiotic_1	open
whole_animal_aposymbiotic_2	open
whole_animal_aposymbiotic_3	open
whole_animal_aposymbiotic_4	open
whole_animal_aposymbiotic_5	open
whole_animal_aposymbiotic_6	open
whole_animal_aposymbiotic_7	open
whole_animal_aposymbiotic_8	open
whole_animal_aposymbiotic_9	open
whole_animal_symbiotic_1	open
whole_animal_symbiotic_10	open
whole_animal_symbiotic_11	open
whole_animal_symbiotic_12	open
whole_animal_symbiotic_13	open
whole_animal_symbiotic_14	open
whole_animal_symbiotic_2	open
whole_animal_symbiotic_3	open
whole_animal_symbiotic_4	open
whole_animal_symbiotic_5	open
whole_animal_symbiotic_6	open
whole_animal_symbiotic_7	open
whole_animal_symbiotic_8	open
whole_animal_symbiotic_9	open

The DNA Methylation page locates this gene by scanning the bisulphite table, which holds one row per cytosine. For the largest datasets that scan takes a while to return; it does not mean the link is broken.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	ready	open →
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →