Gene detail

Detailed information of KXJ27448.1 in Exaiptasia diaphana

Genomic Location: LJWW01000020.1:777434...785512
NR annotation: XP_020897074.1, histone-lysine N-methyltransferase NSD2 isoform X1 [Exaiptasia diaphana]
Species Exaiptasia diaphana · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

KXJ27448.1

ATGCAGATGGCGCAAACGGAAGACAAAGTCTCCCTTTCTACGTCTGAGCAGTTTGAGGAMTCTTCTAGTAAGAAAACGAAACGTATTACACCAAATCCTTCACAAGCAGCAAACGCATCATGGCTAGTTGGGGATGTAGTTTGGGCGAAGATTCCCGGTCATCCTTGGTGGCCATCGATGGTAGCTTACGACCCTAACAGTGCCGTWTATTTCCAGTACAAAGGACGAGCTAGGTACTACCATGTGCAGTTTTTCGGGCAGGATCCAGTCCGCGGATGGGCCTCGGAAAGGTCGGTGATAAAGTTCGAAGGGCTAGAGAAGTTTGAGGCATCAATTCATGCCAAAAATCATCGCGTAACAGCAAGGAGAAGGAGTCACTGGGACACTGCTGTGAAAGTTGGAGAGAAAGCTTTGCCAATGAACAGGCATGAGAGACAATTGTGTTTTACATTTAAATATTATGATAAACTTGCACAAAAATACCCGCAAAAAGTAAAGGGACTGAATGGAATCAATGCCAATGTAAGCCCTACATCTCCTACTAAAACTAGCCAACAAAATAGTTCTCTATTGGTTGATAGTATAGCTGTTCCATCAGACATTACAAATACTGACAAAGAAGATGAAATAGACAGTGCAAAGAATTTGAAAACAAAGTCATCAAGGAAACGAAAGAGAAAGCAGACTGATAAGGATTTGAATTTACCAACTAGTGACACATTATCTCCAGAGACAACTTCWCCATCTGAGCAAACTACCAAACAGAAAAAGAGAATACGAAAGCCAAAGAAGAAWGATCTTGATGAACTTGACCTCAAACCACAAGAATTGCATTTTCAAAATGGAATAACTCAAGAGTTACCAATAAATGGAGGCATTTCACCTACTACTGCATTAAAGCTTAAAATAAGGAAAGTCAAGTCACCTGTAGATACTGGAAAATCTGGTAACAAACGTGGTAAACCTCCTAAGGAAACATTTATCATTGTAAATGATCTAGAAAAACCTGATAATGTTAGTAAAGACTCAACTGACAGTACAAGTACAACATTACCAGATAACAGTAAGCCTGAAGTAACAAGCACAAGTGTGTTAAACACTGAAGAAAAACCCAAGCAAAGAAAAAGAAGAAAGATCGAAAGCAGCTTTGTTACTAATGATACAGCATTTAAAGAAGAAAAACCCAAACCAAAGCGAAAATATGTTCGTAAAAAGCAACTACCTGKAACTGACACCAATAAGTTTGAACAAGAGGACACTAAAGTGAATGAAGTAACTAGTTCAGCTGACATTATTGTAAATAAAAAGCTTTCAAAACAAGAACTTGCTTTAGAAGCATCAGAAGCTAGTAGTGTCATCTCAAGTAATGACAGTGAGGTCGGCAGRTTCAAAGGTGTTTCACTTACTAAAAAAGAAAAGGCAGAAAAAGAACGTGAAGCTGTTTGTGTAGTTTGTGAACAGTGTAATGACCTGATATTCTGTGAAGGAGGTTGCTACAATGCGTACCATCCTGACTGCATAGGACTTTCAACTGCGCCTAAAGGAAAGTTTATCTGCGATGAATGCACATCGGGAATACATTCCTGCTTCATATGCCGACAAACGGGAGATGTGAAACAATGCTGTCAACCTTTATGTGCTAAATATTACCATATTGAATGTGTAAAAGGCAATAATTGCACTAAATTTGACGGAGACCGTTTTTTCTGTCCATTACATTCCTGCGTAACTTGTGTTGTAAKTAAAACACCTCATAGCCGAGGACGTCAAATCCGCTGCGTACGATGTCCAACTTCCTATCATTTATCAGGATGRCTGGAGGCTGGCTGTATGCCGATAACATCTCATCTTATGGTCTGCGCAAAGCATTTTATTCCTCACAAGAACAAGGCTCATCATTCTCATGTCAATGTAAACTGGTGCTTTGTGTGCTCTATTGGTGGTACGTTAATATGCTGTGAAAAGTGTCCAGCAGCTTTTCATCCAGAATGCATCAGCTATGAAGGGATTCCTGAGGGTCATTTCTTCTGTAAGGAGTGTAATGGTGATAAAGCTCTTCTTTATGGGGATATAGTTTGGGTTAAACTTGGCATGTACAGATGGTGGCCAGCACAGATATGCAACCCTCGTGAAGTGCCAACCAACATTCAGAGCATGCGGCACCAGCCTGGTGAATTTCCAGTTATGTTTCTTGGTAGTCATGACTACTACTGGATACACAAAGGGCGTGTGTTTAGTTATCAGGATGGCGATAAAGGCACTGAGTCCAATAACAACAAATATCTGGAGAAGATCTTCAAGAGTGCTTTAGTAGAAGCCAAGGAAAAATATGCTGAGTGGAAAAAAGCCAAAGAAATCAAAGCAGAACAAGACCTACAAAAAATGTCCAAGAAACCTGCTCCATTCAAGCATATTAAGGTAAATAAATGCACAACAGCGCTACGTATAAACAACATTGATCCAAGCGACATGCCTATATGTGAGTGCACTCCAAAGGAAGGTGTCTACTGTGGTCCAGACTCAAACTGCCTGAACAGAGTACTTCAGTTTGAATGTACAGCAAAGTGCCCTGCACAGGATAAATGTCAAAACCAACYTTTTGTCAAGAGGGAGTATGCTGACCTTGAGCCATACCGTGCATTGAATAGAGGTTGGGGTCTAAAAACTAAACAAGATATCAAAAAAGGTTCCTTTGTCATTGAGTATGTTGGTGAACTGATTGACGAAGCAACTTGCTTGGAACGTGTAAAGAAAGGTGATGATGACACAAATTATTACATGCTGACAATTGACAAAGACTGCATCATTGATGCTGGCCCAATGGGAAATCTGTCAAGATTTATGAATCACAGTTGTGCCCCTAACTGCGAGACTCAGAAGTGGACGGTCAGTGGGGAGGTCCGTGTGGGTTTGTTTGCAGCTCGTGATATTGCAGCTGGAGAGGAAATAACTTTTGATTACAGACTGGATTGCAGAGGCAACGAAAAGAAAAAGTGTCATTGTGGCTCCAGCAACTGCAGTGGTTTTCTTGGTGTCCGACCAAAGACGCAAAATGCCCAAATAACAGAAGACAAAATGAAAAAAGCTGCCAAGAATAAGAAGAAAAGACAAAAGAAACCTGTTGTCAAAGAAATCCATGAAGACGATTGCTTTATATGTGGTGATGGTGGCCAGCTTATCATGTGTGATAAGAATGGATGTGCCAAGTGCTACCATGTCAAATGCCTTGAACTCCCTAAGAATCCACATGGTCGATGGCTCTGTCCTTGGCATTTCTGTGATGAATGTGGCAAAAATGCAACCATCAAATGTATTGAGTGCCCRAACTCATTTTGCAAACTCCATGCTGAAAACCAAGTTATATGTGTCGGGGAAGGAAAGTACATGTGTTTGGACCACAGCACTGAGGAAACCCAGAAAGAKGAAGAAAAACTCCCAGATGTCTCCCAGGATCTTGGTCAATTTTGTAATTTAGGATTTGGAGATGATTTAGTTAARGAAATACCAGGAATTACCTCTTTAGATCTGAAAGATCTTCCTCAAACCCCRCAGGATATGGATCAAGTCCAGTGA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q8BVE8	Histone-lysine N-methyltransferase NSD2 OS=Mus musculus OX=10090 GN=Nsd2 PE=1 SV=2
O96028	Histone-lysine N-methyltransferase NSD2 OS=Homo sapiens OX=9606 GN=NSD2 PE=1 SV=1
Q9BZ95	Histone-lysine N-methyltransferase NSD3 OS=Homo sapiens OX=9606 GN=NSD3 PE=1 SV=1

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0002896 (this species only)
Ubiquitin family	E3\|E3 activity RING\|PHD · all ubiquitin genes in this species

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF17982 all species →	C5HCH	NSD Cys-His rich domain	Domain	Interproscan
PF00855 all species →	PWWP	PWWP domain	Domain	Interproscan
PF00856 all species →	SET	SET domain	Family	Interproscan
PF17907 all species →	AWS	AWS domain	Domain	Interproscan
PF00628 all species →	PHD	PHD-finger	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR046341 all species →	Homologous_superfamily	SET domain superfamily	Interproscan
IPR013083 all species →	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	Interproscan
IPR011011 all species →	Homologous_superfamily	Zinc finger, FYVE/PHD-type	Interproscan
IPR019786 all species →	Conserved_site	Zinc finger, PHD-type, conserved site	Interproscan
IPR000313 all species →	Domain	PWWP domain	Interproscan
IPR050777 all species →	Family	SET2 Histone-Lysine N-Methyltransferase	Interproscan
IPR019787 all species →	Domain	Zinc finger, PHD-finger	Interproscan
IPR041306 all species →	Domain	NSD, Cys-His rich domain	Interproscan
IPR006560 all species →	Domain	AWS domain	Interproscan
IPR001965 all species →	Domain	Zinc finger, PHD-type	Interproscan
IPR003616 all species →	Domain	Post-SET domain	Interproscan
IPR001214 all species →	Domain	SET domain	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR22884 all species →	SET DOMAIN PROTEINS	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005634 all species →	Cellular Component	nucleus	Interproscan
GO:0042054 all species →	Molecular Function	histone methyltransferase activity	Interproscan
GO:0005515 all species →	Molecular Function	protein binding	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K11424	WHSC1, MMSET, NSD2; [histone H3]-lysine36 N-dimethyltransferase NSD2	EC:2.1.1.357	Chromosome and associated proteins	ko03036	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of KXJ27448.1 across 72 RNA-seq samples of Exaiptasia diaphana. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

72Samples

70TPM > 0

2Conditions

41.2Max TPM

21.8Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM	Mean, relative to max
whole animal · aposymbiotic	36	35	16.88	32.42
whole animal · symbiotic	36	35	26.72	41.19

Per sample · hover a bar for the full sample record · show / hide the sample table

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR6202357	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	32.42
SRR6202345	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	28.19
SRR6202344	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	27.74
SRR6202234	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	23.95
SRR6202258	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	22.15
SRR6202241	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	22.06
SRR6202233	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	21.84
SRR6202260	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	21.75
SRR6202261	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	21.67
SRR6202346	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	21.03
SRR6202259	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	19.90
SRR6202211	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	19.84
SRR6202242	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	19.78
SRR6202210	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	19.11
SRR6202212	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	18.28
SRR6202207	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	17.75
SRR6202208	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	17.05
SRR6202237	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	15.94
SRR6202209	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	15.89
SRR6202254	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	15.58
SRR6202205	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	15.56
SRR6202363	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	15.05
SRR6202206	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	14.78
SRR6202358	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	14.20
SRR6202255	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	13.92
SRR6202235	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	13.67
SRR6202236	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	13.08
SRR6202343	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	12.91
SRR6202238	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	12.57
SRR6202257	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	11.68
SRR6202256	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	10.57
SRR6202204	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	9.76
SRR6202240	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	9.50
SRR6202239	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	9.26
SRR6202203	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	9.25
SRR6202364	whole animal · aposymbiotic	whole animal	not recorded	aposymbiotic	SRP120942	0.00
SRR6202305	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	41.19
SRR6202349	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	39.73
SRR6202285	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	39.47
SRR6202284	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	39.39
SRR6202306	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	38.83
SRR6202303	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	38.56
SRR6202304	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	37.91
SRR6202353	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	32.22
SRR6202282	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	31.80
SRR6202310	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	31.53
SRR6202309	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	29.05
SRR6202308	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	29.04
SRR6202283	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	28.70
SRR6202348	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	27.45
SRR6202307	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	26.90
SRR6202263	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	25.17
SRR6202262	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	24.99
SRR6202340	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	24.26
SRR6202352	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	24.14
SRR6202281	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	23.89
SRR6202280	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	23.80
SRR6202341	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	23.62
SRR6202356	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	23.58
SRR6202276	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	23.26
SRR6202278	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	23.01
SRR6202339	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	22.90
SRR6202350	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	22.21
SRR6202277	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	21.87
SRR6202351	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	21.67
SRR6202338	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	21.55
SRR6202279	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	21.32
SRR6202347	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	20.54
SRR6202355	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	20.36
SRR6202337	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	20.19
SRR6202342	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	17.70
SRR6202354	whole animal · symbiotic	whole animal	not recorded	symbiotic	SRP120942	0.00

Source: CnidoSite RNA-seq expression matrices (EDIAP_TPM, StringTie quantification over 72 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.