Genomic Location: scaffold_216:328405...356334
NR annotation: KAJ7323466.1, Poly [ADP-ribose] polymerase 1 [Desmophyllum pertusum]
Species Lophelia pertusa · all data for this species · gene families
| CDS |
| OS493_031389-T1 |
| Transcript |
| OS493_031389-T1 |
| Protein |
| OS493_031389-T1 |
| UniProt accession | Description |
|---|---|
| P31669 | Poly [ADP-ribose] polymerase 1 (Fragment) OS=Xenopus laevis OX=8355 GN=parp1 PE=2 SV=1 |
| P27008 | Poly [ADP-ribose] polymerase 1 OS=Rattus norvegicus OX=10116 GN=Parp1 PE=1 SV=4 |
| P26446 | Poly [ADP-ribose] polymerase 1 OS=Gallus gallus OX=9031 GN=PARP1 PE=1 SV=2 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0001312 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF02877 all species → | PARP_reg | Poly(ADP-ribose) polymerase, regulatory domain | Domain | Interproscan |
| PF05406 all species → | WGR | WGR domain | Domain | Interproscan |
| PF00645 all species → | zf-PARP | Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region | Domain | Interproscan |
| PF08063 all species → | PADR1_Zn_ribbon | PADR1 domain, zinc ribbon fold | Domain | Interproscan |
| PF00533 all species → | BRCT | BRCA1 C Terminus (BRCT) domain | Family | Interproscan |
| PF21728 all species → | PADR1_N | PADR1, N-terminal helical domain | Domain | Interproscan |
| PF00644 all species → | PARP | Poly(ADP-ribose) polymerase catalytic domain | Family | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR004102 all species → | Domain | Poly(ADP-ribose) polymerase, regulatory domain | Interproscan |
| IPR001357 all species → | Domain | BRCT domain | Interproscan |
| IPR003034 all species → | Domain | SAP domain | Interproscan |
| IPR036930 all species → | Homologous_superfamily | WGR domain superfamily | Interproscan |
| IPR008288 all species → | Family | Poly [ADP-ribose] polymerase | Interproscan |
| IPR001510 all species → | Domain | Zinc finger, PARP-type | Interproscan |
| IPR036957 all species → | Homologous_superfamily | Zinc finger, PARP-type superfamily | Interproscan |
| IPR012317 all species → | Domain | Poly(ADP-ribose) polymerase, catalytic domain | Interproscan |
| IPR008893 all species → | Domain | WGR domain | Interproscan |
| IPR012982 all species → | Domain | PARP1-like, PADR1 domain, zinc ribbon fold | Interproscan |
| IPR049296 all species → | Domain | PARP1-like, PADR1 domain, N-terminal helical subdomain | Interproscan |
| IPR036616 all species → | Homologous_superfamily | Poly(ADP-ribose) polymerase, regulatory domain superfamily | Interproscan |
| IPR036420 all species → | Homologous_superfamily | BRCT domain superfamily | Interproscan |
| IPR050800 all species → | Family | ADP-ribosyltransferase diphtheria toxin-like | Interproscan |
| IPR038650 all species → | Homologous_superfamily | PADR1, C-terminal domain superfamily | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR10459 all species → | DNA LIGASE | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0003950 all species → | Molecular Function | NAD+-protein poly-ADP-ribosyltransferase activity | Interproscan |
| GO:0003677 all species → | Molecular Function | DNA binding | Interproscan |
| GO:0005634 all species → | Cellular Component | nucleus | Interproscan |
| GO:0008270 all species → | Molecular Function | zinc ion binding | Interproscan |
| GO:0051287 all species → | Molecular Function | NAD binding | Interproscan |
| GO:0005730 all species → | Cellular Component | nucleolus | Interproscan |
| GO:0006302 all species → | Biological Process | double-strand break repair | Interproscan |
| GO:0070212 all species → | Biological Process | protein poly-ADP-ribosylation | Interproscan |
| GO:1990404 all species → | Molecular Function | NAD+-protein ADP-ribosyltransferase activity | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K24070 | PARP1; poly [ADP-ribose] polymerase 1 | EC:2.4.2.30 | DNA repair and recombination proteins | ko03400 | deepkoala |
Transcript abundance of OS493_031389-T1 across 110 RNA-seq samples of Lophelia pertusa. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| polyp at pH7 9 | 18 | 18 | 5.90 | 9.51 | |
| polyp at pH7 6 | 18 | 18 | 6.42 | 11.55 | |
| coral polyp · control treatment | 16 | 16 | 5.20 | 24.96 | |
| coral polyp · oil and dispersant treatment | 16 | 16 | 3.10 | 15.29 | |
| coral polyp · oil treatment | 16 | 16 | 3.83 | 7.46 | |
| coral polyp · dispersant treatment | 16 | 16 | 4.56 | 10.79 | |
| Polyp | 10 | 10 | 2.84 | 6.14 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR11359510 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 9.51 |
| SRR11359511 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 9.41 |
| SRR11359494 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 8.86 |
| SRR11359509 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 8.43 |
| SRR11359495 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 8.23 |
| SRR11359508 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 6.86 |
| SRR11359518 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 6.05 |
| SRR11359497 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 5.03 |
| SRR11359506 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 5.00 |
| SRR11359523 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 4.97 |
| SRR11359522 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 4.84 |
| SRR11359507 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 4.73 |
| SRR11359499 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 4.66 |
| SRR11359498 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 4.45 |
| SRR11359496 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 4.41 |
| SRR11359521 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 3.82 |
| SRR11359519 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 3.58 |
| SRR11359520 | polyp at pH7 9 | not recorded | not recorded | not recorded | - | 3.36 |
| SRR11359504 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 11.55 |
| SRR11359505 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 11.13 |
| SRR11359501 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 11.04 |
| SRR11359502 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 8.36 |
| SRR11359500 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 7.22 |
| SRR11359514 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 7.14 |
| SRR11359503 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 6.61 |
| SRR11359515 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 6.60 |
| SRR11359517 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 6.32 |
| SRR11359513 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 6.16 |
| SRR11359529 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 5.54 |
| SRR11359512 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 5.52 |
| SRR11359516 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 5.36 |
| SRR11359528 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 4.80 |
| SRR11359526 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 3.92 |
| SRR11359527 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 3.82 |
| SRR11359525 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 2.95 |
| SRR11359524 | polyp at pH7 6 | not recorded | not recorded | not recorded | - | 1.42 |
| SRR16705973 | coral polyp · control treatment | coral polyp | polyp | control treatment | SRP344271 | 24.96 |
| SRR16705960 | coral polyp · control treatment | coral polyp | polyp | control treatment | SRP344271 | 6.28 |
| SRR16705972 | coral polyp · control treatment | coral polyp | polyp | control treatment | SRP344271 | 5.95 |
| SRR16705974 | coral polyp · control treatment | coral polyp | polyp | control treatment | SRP344271 | 5.78 |
| SRR16705942 | coral polyp · control treatment | coral polyp | polyp | control treatment | SRP344271 | 5.64 |
| SRR16705943 | coral polyp · control treatment | coral polyp | polyp | control treatment | SRP344271 | 4.70 |
| SRR16705946 | coral polyp · control treatment | coral polyp | polyp | control treatment | SRP344271 | 4.66 |
| SRR16705965 | coral polyp · control treatment | coral polyp | polyp | control treatment | SRP344271 | 4.39 |
| SRR16705957 | coral polyp · control treatment | coral polyp | polyp | control treatment | SRP344271 | 3.77 |
| SRR16705975 | coral polyp · control treatment | coral polyp | polyp | control treatment | SRP344271 | 3.67 |
| SRR16705971 | coral polyp · control treatment | coral polyp | polyp | control treatment | SRP344271 | 3.59 |
| SRR16705991 | coral polyp · control treatment | coral polyp | polyp | control treatment | SRP344271 | 3.53 |
| SRR16705970 | coral polyp · control treatment | coral polyp | polyp | control treatment | SRP344271 | 2.45 |
| SRR16705989 | coral polyp · control treatment | coral polyp | polyp | control treatment | SRP344271 | 1.75 |
| SRR16705990 | coral polyp · control treatment | coral polyp | polyp | control treatment | SRP344271 | 1.23 |
| SRR16705992 | coral polyp · control treatment | coral polyp | polyp | control treatment | SRP344271 | 0.87 |
| SRR16705977 | coral polyp · oil and dispersant treatment | coral polyp | polyp | oil and dispersant treatment | SRP344271 | 15.29 |
| SRR16705948 | coral polyp · oil and dispersant treatment | coral polyp | polyp | oil and dispersant treatment | SRP344271 | 5.78 |
| SRR16705997 | coral polyp · oil and dispersant treatment | coral polyp | polyp | oil and dispersant treatment | SRP344271 | 4.39 |
| SRR16706005 | coral polyp · oil and dispersant treatment | coral polyp | polyp | oil and dispersant treatment | SRP344271 | 3.84 |
| SRR16705976 | coral polyp · oil and dispersant treatment | coral polyp | polyp | oil and dispersant treatment | SRP344271 | 3.21 |
| SRR16705993 | coral polyp · oil and dispersant treatment | coral polyp | polyp | oil and dispersant treatment | SRP344271 | 2.88 |
| SRR16706004 | coral polyp · oil and dispersant treatment | coral polyp | polyp | oil and dispersant treatment | SRP344271 | 2.52 |
| SRR16705982 | coral polyp · oil and dispersant treatment | coral polyp | polyp | oil and dispersant treatment | SRP344271 | 2.51 |
| SRR16705978 | coral polyp · oil and dispersant treatment | coral polyp | polyp | oil and dispersant treatment | SRP344271 | 2.24 |
| SRR16705979 | coral polyp · oil and dispersant treatment | coral polyp | polyp | oil and dispersant treatment | SRP344271 | 2.07 |
| SRR16705944 | coral polyp · oil and dispersant treatment | coral polyp | polyp | oil and dispersant treatment | SRP344271 | 1.14 |
| SRR16705995 | coral polyp · oil and dispersant treatment | coral polyp | polyp | oil and dispersant treatment | SRP344271 | 1.05 |
| SRR16705947 | coral polyp · oil and dispersant treatment | coral polyp | polyp | oil and dispersant treatment | SRP344271 | 0.82 |
| SRR16705945 | coral polyp · oil and dispersant treatment | coral polyp | polyp | oil and dispersant treatment | SRP344271 | 0.65 |
| SRR16705994 | coral polyp · oil and dispersant treatment | coral polyp | polyp | oil and dispersant treatment | SRP344271 | 0.65 |
| SRR16705996 | coral polyp · oil and dispersant treatment | coral polyp | polyp | oil and dispersant treatment | SRP344271 | 0.64 |
| SRR16706001 | coral polyp · oil treatment | coral polyp | polyp | oil treatment | SRP344271 | 7.46 |
| SRR16705999 | coral polyp · oil treatment | coral polyp | polyp | oil treatment | SRP344271 | 6.89 |
| SRR16706000 | coral polyp · oil treatment | coral polyp | polyp | oil treatment | SRP344271 | 6.18 |
| SRR16705950 | coral polyp · oil treatment | coral polyp | polyp | oil treatment | SRP344271 | 5.12 |
| SRR16705964 | coral polyp · oil treatment | coral polyp | polyp | oil treatment | SRP344271 | 4.96 |
| SRR16705998 | coral polyp · oil treatment | coral polyp | polyp | oil treatment | SRP344271 | 4.94 |
| SRR16705952 | coral polyp · oil treatment | coral polyp | polyp | oil treatment | SRP344271 | 4.32 |
| SRR16705984 | coral polyp · oil treatment | coral polyp | polyp | oil treatment | SRP344271 | 3.80 |
| SRR16705951 | coral polyp · oil treatment | coral polyp | polyp | oil treatment | SRP344271 | 3.78 |
| SRR16705961 | coral polyp · oil treatment | coral polyp | polyp | oil treatment | SRP344271 | 3.19 |
| SRR16705949 | coral polyp · oil treatment | coral polyp | polyp | oil treatment | SRP344271 | 3.02 |
| SRR16705983 | coral polyp · oil treatment | coral polyp | polyp | oil treatment | SRP344271 | 2.31 |
| SRR16705980 | coral polyp · oil treatment | coral polyp | polyp | oil treatment | SRP344271 | 1.57 |
| SRR16705962 | coral polyp · oil treatment | coral polyp | polyp | oil treatment | SRP344271 | 1.41 |
| SRR16705963 | coral polyp · oil treatment | coral polyp | polyp | oil treatment | SRP344271 | 1.23 |
| SRR16705981 | coral polyp · oil treatment | coral polyp | polyp | oil treatment | SRP344271 | 1.12 |
| SRR16705958 | coral polyp · dispersant treatment | coral polyp | polyp | dispersant treatment | SRP344271 | 10.79 |
| SRR16705959 | coral polyp · dispersant treatment | coral polyp | polyp | dispersant treatment | SRP344271 | 9.14 |
| SRR16706003 | coral polyp · dispersant treatment | coral polyp | polyp | dispersant treatment | SRP344271 | 7.11 |
| SRR16706002 | coral polyp · dispersant treatment | coral polyp | polyp | dispersant treatment | SRP344271 | 6.97 |
| SRR16705954 | coral polyp · dispersant treatment | coral polyp | polyp | dispersant treatment | SRP344271 | 6.22 |
| SRR16705956 | coral polyp · dispersant treatment | coral polyp | polyp | dispersant treatment | SRP344271 | 4.86 |
| SRR16705988 | coral polyp · dispersant treatment | coral polyp | polyp | dispersant treatment | SRP344271 | 4.46 |
| SRR16705955 | coral polyp · dispersant treatment | coral polyp | polyp | dispersant treatment | SRP344271 | 3.95 |
| SRR16705969 | coral polyp · dispersant treatment | coral polyp | polyp | dispersant treatment | SRP344271 | 3.91 |
| SRR16705986 | coral polyp · dispersant treatment | coral polyp | polyp | dispersant treatment | SRP344271 | 3.62 |
| SRR16705967 | coral polyp · dispersant treatment | coral polyp | polyp | dispersant treatment | SRP344271 | 2.90 |
| SRR16705987 | coral polyp · dispersant treatment | coral polyp | polyp | dispersant treatment | SRP344271 | 2.74 |
| SRR16705966 | coral polyp · dispersant treatment | coral polyp | polyp | dispersant treatment | SRP344271 | 2.39 |
| SRR16705968 | coral polyp · dispersant treatment | coral polyp | polyp | dispersant treatment | SRP344271 | 2.14 |
| SRR16705953 | coral polyp · dispersant treatment | coral polyp | polyp | dispersant treatment | SRP344271 | 1.11 |
| SRR16705985 | coral polyp · dispersant treatment | coral polyp | polyp | dispersant treatment | SRP344271 | 0.56 |
| SRR23025710 | Polyp | not recorded | not recorded | not recorded | - | 6.14 |
| SRR23025713 | Polyp | not recorded | not recorded | not recorded | - | 4.27 |
| SRR23025711 | Polyp | not recorded | not recorded | not recorded | - | 4.22 |
| SRR23025708 | Polyp | not recorded | not recorded | not recorded | - | 3.33 |
| SRR23025709 | Polyp | not recorded | not recorded | not recorded | - | 3.08 |
| SRR7746666 | Polyp | not recorded | not recorded | not recorded | - | 1.89 |
| SRR23025712 | Polyp | not recorded | not recorded | not recorded | - | 1.64 |
| SRR7746667 | Polyp | not recorded | not recorded | not recorded | - | 1.48 |
| SRR7746669 | Polyp | not recorded | not recorded | not recorded | - | 1.30 |
| SRR7746668 | Polyp | not recorded | not recorded | not recorded | - | 1.05 |
Source: CnidoSite RNA-seq expression matrices (LPERT_TPM,
StringTie quantification over 110 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Lophelia pertusa tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 20 | OS493_031280-T1 | 0.873699760870356 |
| Negatively correlated | 5 | OS493_029928-T1 | -0.512455425474994 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Lophelia pertusa, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |