Gene detail

Detailed information of XP_044184151.1 in Acropora millepora

Genomic Location: NC_058077.1:20530807...20553760
NR annotation: XP_044184151.1, DNA mismatch repair protein Msh6-like isoform X2 [Acropora millepora]
Species Acropora millepora · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

XP_044184151.1

ATGGCGACGCTTTTCTCTTACTTCAACAAAACACCAAAAGGCAAGAAACCACCTTCTCCAGTCTGCAGTGAAATTGCAGACAAAAAGAAAAGCAATTCCCCGAAAGAAGGAGCAAAAGGCTTTTCGCCCATAAACGAGGACAAAGCAAGAGTTAACGGGAAGGCAAAGAGAAAGAACGAAGAATCATGTTCTGGAGAAATTCAACTTTATGACGTTGTGTGGGCTAAACTCGAGGGTCATCCTTGGTGGCCAAGTTTGGTTTGCAAGCATCCTACGCAAGATGCATTTCAGCAAAAGGGGAAGTATCATGTACAGTTCTTCGGCGAACCGCCAAGTAGAGCTTGGGTGAAGATGAATAATGTAAAAGCATTCATTAAAAGGCTGAATAACAATGTGGTCGACCCAACAATAAAAAAGGCAGCTCAACAAGCAGAGGATACCCTGTCTCTTGCAAGAGAACAAAGAAACAAACTTGTGAAGTGCTTAGCCTCGGATGAGGAAGAATCTCCAGAGGAAGAGGGACAGTTAATGCAGTTGGATGGAGAGAGTTCGGACAAAGCCCTGAATAGTCAGAAAAGAAAGAATGCAGGTCGTGATGATGATGATGATGACAGCGATGAGGAGGTCATAGGAAGGAAGAACGGCAAACGTCCCAGGAGGAAAGCTACTCTAAGAAATTCTAAAACAAAGAAAAGACGGGTAATTCAATCTGGGTCTGAAGGAGATTCTGAAGATGATTATAAACCTGATGACGATAATGATGACGATGATGAGAGCTGTAGCAGCGGTGTCGATGAAAACGAGTTAGAAGATGAGGTGCTTCATTCTGAAGATGAGATTGAAGATAACACTGAAAAGCAATCACGTAAGCGCAAAAGAGGAAAAGTGTTTACCCCACATCAGCAGAAAACAAAGTCTCGTAAACCTTCCACACCTTGCACACCTGTCACTAGTGGTGCATCTTCAGTAAACACACCTTCACCCTCTGGAGTACTGCAAGGGACGTTAGCAAAGAAGGTATCAAGCTCGGCCAGTAAAGCTGCGGAATCTTTGGCCAGATTCCAAATGACTGCATCACCAACCCCTAGCTCAAATGTAGACAAGGAAGGTGGTGAAGGAAGCTATACTCATGAAAGGTTGGACTGGTTAAAAGAAGACAAGAGAAGAGACAAACATGGTAGACCAATGTCTCACCCTGAATATGATCCAAGAACACTACTGGTTCCTTCGTCTTTCTTAACCTCCAAAGAAGTAACACCTGCCATGAAACAGTGGTGGCAGTTAAAAGTTGAAAATTTTGATACAATCCTCTTCTTTAAGGTTGGCAAGTTCTATGAATTGTACAACATGGATGCAACTGTTGGTGTGAAAGAACTTGGGTTGATATATATGAAGGGCAATTTTGCTCATGCTGGGTTTCCGGAAATTGCATTTGGTCGGTACTCTGATACTCTAATTCAGAAGGGTTACAAGGTTGCAAGAGTGGAACAAACGGAAACCCCAGAGATGATGAAAGAGAGATGCAGGAAAACTCTCTCTGTGTCAAGGTCTGACCAGGTGGTCAAGAGGGAAATATGCGCAGTTATCACCAAAGGAACAAAGACATACAGTTTTCTTGATGGTGACTGCACGGACAGCGAGGCAGCTTACCTTCTAGCTATTTCTGAGAAGGGATCTGATGATTCTTCAGGAGGTGAAAGTGTTTATGGAGTTTGTTTTGTCGATACATCTATTGGAAGATTTCATATTGGACAATTTCAAGATGATCGTCAAGCTTCTCGCCTCAGGACTCTAATTGCTCATTATACTCCAGTGCAGGTGTTATGTTGCCGAGGAGGTGTAACCTTGAAGACCCAACATGTGCTTAGTCACGAATTAATGTCATCTATGAAAGAGTATCTTATTCCAGGGTCACAGTTCTGGGAAGCAAGCAAGACATTAAAAGTCTTAGCAGAGGAAGAATATTTCAAAGAAGACAAGACAAGCACAGAGAATTCTGTTAAGAGCTGGCCTGAGATATTGAGAAAATTAACTGATGGAGATTCCTTAGGATTGACACCGGCTGATGGCAGTGAATTAGCGTTGAGTGCTCTTGGTGCAGTTGTATGGTATCTGAAAAAGTCCCTCATCGATCATGAAGTGTTGTCAATGGGGAATTTTGAGGAATACACTCCCCTGGACAGTTCTCCAAACGCTGGAAGAAGTGCAGCTTTCATGAAAGGAAGACAGCACATGATTCTTGATAACGTAACTTTGACAAATCTGGACGTTATTCCGTATGGTCCTGATTCATCTTTAGAAGGCACATTACTGGAGAGATTAGATAACTGTTCTACTCCATTTGGCAAACGTTTGTTTAAGCAATGGCTTTGTGCTCCTCTATGTAATCCGACAGCGATCAATGACAGGTTGAATGCAGTTGAGGATCTCATGGCGAACCGGGGATTAATGGCAGAATGCAAGGAACTGTTGCGAACCTTACCAGACTTGGAAAGATTATTGAAGAAAATCCATGCGTTGAGTTTACCCAAAGACCCAAACCACCCGGCCCACCGAGCCATTTTGTACAATGAAGACACGTACAGTAAACGGAAAATAAACGACTTTCTTACTGTGTTGGAAGGCTTCGGTAAAGCGACGGAGATCGTTGCTCTGTTTTCAAACCACTCCTCATCATTCAGATCCAAACTTCTTCTTCAAGTGATTTCAGAAGAACGCCAATTTCCCTGCCTTAAGGAACTTTTGCTAACATTCAAGCATGCTTTTGATCACAACAAGGCAAGGAACGAAGGAGTTATTTTACCAAAGCCAGGTGTTGATCCAGATTATGATGGCGCTTTGGCGGACATTAACGCTACAAAAGGATGGTTTGACAAGTATCTAAAAAAGCAGTGTGCCGCACTGGGATGTAAGGTAACTTACTGGGGATCAGCCAAGAATCGTTTCCAACTGGAAGTCCCAGATTCCATTCGGAAAATTCCGGATGAGTACACTCTGCAGTCTCAGAAGAAAGGATTTAAACGTTACTGGACCGCAGAGATCGAAGATAAACTGGCTGAGCTCGTGAATGCGGAGGAAAGACGCGAGGAAGCTTTGAAGGACACCATGAGACACGTGTTCCATAAGTTTGACCAAGAGTACAAGACTTGGGACAAAGCTGTCCAGTGTCTTGCTGTGTTGGACTCGCTTATAAGCCTTGCTTCTTACAGCTCGAAATGTGATGGTCCAATGTGTCGACCTGAAATCGTTCTCCCTGAACAAACTGAAGCTGGCAATTTCCAGCCATTCTTTGAAATCCGCGATGGCCGCCACCCTTGCATTTCTCGGACCTTTAGTGGCGGTGATTTCATTCCTAATGACACTGTTGTTGGGATAAAAAATGACGAGGACTGCGAGGAGACAGCGGTTAACAGTCACAGCACATGCGTGTTAGTCACCGGTCCTAACATGGGTGGCAAATCAACTCTGATGAGACAAGCAGGACTTATTTTGATCATGGCGCAAATGGGGTGTTTCGTGCCAGCTGAGAAGTGCCGTCTAACCCCTGTGGATCGTGTTTTTACCAGACTTGGTGCTCAAGACAGGATTTTATCAGGTGAAAGTACGTTCTTTGTGGAGCTCAATGAAACATCTACCATTCTCAAACACGCTACCCAGCATTCACTGGTCATCGTGGACGAGCTTGGACGAGGGACCGCCACGTATGATGGGACAGCTATCGCTTGCGCTGTAGTTCGAGCGCTGTCGAGGCAGATAAGATGCAGAACTCTCTTCTCTACACATTACCATTCACTTGTGGAAGAGTTCTCCGCCGATGAGAATGTTCGTCTTGGTCATATGGCCTGCATGGTTGAAAATGAGGACGACACAGACCCCATCAAGGAAACCATAACGTTCTTATACAAATTTGTCAAAGGCGCATGTCCGAAGAGCTACGGGTTCAATGCAGCGAGATTGGCTGGCATTCCAGATGAGGTGATAGCACTTGCTGTGAAAAAAGCCAGACAATTCGAAGAATCAACGGAAAGAATAAAAATCTTCAGGCAACTTCTTGCAAAAGACAAGTACAGTGCTCAAGATATTTTAAGTCTGCGAGAAAGATTTCATTAG

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
E1BYJ2	DNA mismatch repair protein Msh6 OS=Gallus gallus OX=9031 GN=MSH6 PE=3 SV=2
P52701	DNA mismatch repair protein Msh6 OS=Homo sapiens OX=9606 GN=MSH6 PE=1 SV=2
P54276	DNA mismatch repair protein Msh6 OS=Mus musculus OX=10090 GN=Msh6 PE=1 SV=3

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0002965 (this species only) · gene tree & orthology

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF05190 all species →	MutS_IV	MutS family domain IV	Domain	Interproscan
PF00488 all species →	MutS_V	MutS domain V	Domain	Interproscan
PF05188 all species →	MutS_II	MutS domain II	Domain	Interproscan
PF01624 all species →	MutS_I	MutS domain I	Domain	Interproscan
PF05192 all species →	MutS_III	MutS domain III	Domain	Interproscan
PF00855 all species →	PWWP	PWWP domain	Domain	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR036187 all species →	Homologous_superfamily	DNA mismatch repair protein MutS, core domain superfamily	Interproscan
IPR000432 all species →	Domain	DNA mismatch repair protein MutS, C-terminal	Interproscan
IPR017261 all species →	Family	DNA mismatch repair protein MutS/MSH	Interproscan
IPR000313 all species →	Domain	PWWP domain	Interproscan
IPR007696 all species →	Domain	DNA mismatch repair protein MutS, core	Interproscan
IPR007861 all species →	Domain	DNA mismatch repair protein MutS, clamp	Interproscan
IPR045076 all species →	Family	DNA mismatch repair MutS family	Interproscan
IPR007860 all species →	Domain	DNA mismatch repair protein MutS, connector domain	Interproscan
IPR027417 all species →	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	Interproscan
IPR036678 all species →	Homologous_superfamily	MutS, connector domain superfamily	Interproscan
IPR007695 all species →	Domain	DNA mismatch repair protein MutS-like, N-terminal	Interproscan
IPR016151 all species →	Homologous_superfamily	DNA mismatch repair protein MutS, N-terminal	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR11361 all species →	DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0005524 all species →	Molecular Function	ATP binding	Interproscan
GO:0006298 all species →	Biological Process	mismatch repair	Interproscan
GO:0030983 all species →	Molecular Function	mismatched DNA binding	Interproscan
GO:0003690 all species →	Molecular Function	double-stranded DNA binding	Interproscan
GO:0005634 all species →	Cellular Component	nucleus	Interproscan
GO:0032301 all species →	Cellular Component	MutSalpha complex	Interproscan
GO:0140664 all species →	Molecular Function	ATP-dependent DNA damage sensor activity	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K08737	MSH6; DNA mismatch repair protein MSH6	-	DNA repair and recombination proteins	ko03400	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_044184151.1 across 54 RNA-seq samples of Acropora millepora. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

54Samples

3TPM > 0

2Conditions

159.3Max TPM

4.9Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM	Mean, relative to max
whole larvae	30	1	1.41	42.19
branch	24	2	9.37	159.31

Per sample · hover a bar for the full sample record

Show the sample table (54 samples)

SRA run	Condition	Tissue	Developmental stage	Treatment	Study	TPM
SRR1929605	whole larvae	whole larvae	adult	not recorded	SRP056536	42.19
SRR1929606	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929607	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929608	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929609	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929610	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929611	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929612	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929613	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929614	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929615	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929616	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929617	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929618	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929619	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929620	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929621	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929622	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929623	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929624	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929625	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929626	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929627	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929628	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929629	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929630	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929631	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929632	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929633	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929634	whole larvae	whole larvae	adult	not recorded	SRP056536	0.00
SRR1929586	branch	branch	adult	not recorded	SRP056536	159.31
SRR1929590	branch	branch	adult	not recorded	SRP056536	65.46
SRR1929581	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929582	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929583	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929584	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929585	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929587	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929588	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929589	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929591	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929592	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929593	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929594	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929595	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929596	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929597	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929598	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929599	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929600	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929601	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929602	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929603	branch	branch	adult	not recorded	SRP056536	0.00
SRR1929604	branch	branch	adult	not recorded	SRP056536	0.00

Source: CnidoSite RNA-seq expression matrices (AMILL_TPM, StringTie quantification over 54 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Acropora millepora tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

Direction	Partners	Most correlated partner	PCC
Positively correlated	25	XP_044184294.1	0.924670044489724
Negatively correlated	3	XP_029203064.2	-0.292898014422874

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Acropora millepora, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

Dataset	Tissue / stage	Cells	Cell types	This gene	Marker of
AMILL_whole_adult	Whole adults · Adult tissues/organs	25,164	27	not in this dataset	–

A gene is in viewer when the dataset ships a per-cell expression vector for it; marker only means it is in the dataset’s ranked marker table but no vector was exported, so the atlas cannot draw it; not in this dataset means the dataset’s own gene-ID table does not list it, so no expression claim can be made for that dataset. unmapped is deliberately weaker still: the dataset has no gene-ID table on CnidoSite yet, so nothing is claimed in either direction. Where markers are listed, the numbers are log2 fold change and the percentage of cells of that type in which the gene was detected.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

DNA methylation (bisulphite samples)

Sample	Methylation profile
planula	open

The DNA Methylation page locates this gene by scanning the bisulphite table, which holds one row per cytosine. For the largest datasets that scan takes a while to return; it does not mean the link is broken.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

Analysis	What it does	Status
Primer design	Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.	template found	open →
BLAST	Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.	template found	open →
Expression heatmap	Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.	ready	open →
Gene family / orthogroup	Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.		open →
Gene set analysis	Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.		open →