Genomic Location: NC_088921.1:21877168...21999029
NR annotation: XP_047134104.1, histone-lysine N-methyltransferase SETDB1 isoform X4 [Hydra vulgaris]
Species Hydra vulgaris · all data for this species · gene families
| CDS |
| LOC100203637 |
| Transcript |
| rna-XM_065790297.1 |
| Protein |
| XP_065646369.1 |
| UniProt accession | Description |
|---|---|
| Q08BR4 | Histone-lysine N-methyltransferase SETDB1-B OS=Danio rerio OX=7955 GN=setdb1b PE=2 SV=2 |
| O88974 | Histone-lysine N-methyltransferase SETDB1 OS=Mus musculus OX=10090 GN=Setdb1 PE=1 SV=1 |
| Q6INA9 | Histone-lysine N-methyltransferase SETDB1 OS=Xenopus laevis OX=8355 GN=setdb1 PE=2 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0002101 (this species only) · gene tree & orthology |
| Transcription factor family | MBD · all TF in this species |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF18359 all species → | Tudor_5 | Histone methyltransferase Tudor domain 1 | Domain | Interproscan |
| PF05033 all species → | Pre-SET | Pre-SET motif | Family | Interproscan |
| PF18358 all species → | Tudor_4 | Histone methyltransferase Tudor domain | Domain | Interproscan |
| PF00856 all species → | SET | SET domain | Family | Interproscan |
| PF01429 all species → | MBD | Methyl-CpG binding domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR016177 all species → | Homologous_superfamily | DNA-binding domain superfamily | Interproscan |
| IPR007728 all species → | Domain | Pre-SET domain | Interproscan |
| IPR001214 all species → | Domain | SET domain | Interproscan |
| IPR001739 all species → | Domain | Methyl-CpG DNA binding | Interproscan |
| IPR041291 all species → | Domain | Histone methyltransferase, Tudor domain 1 | Interproscan |
| IPR003616 all species → | Domain | Post-SET domain | Interproscan |
| IPR041292 all species → | Domain | Histone methyltransferase, Tudor domain 2 | Interproscan |
| IPR051516 all species → | Family | Histone-lysine N-methyltransferase SETDB | Interproscan |
| IPR046341 all species → | Homologous_superfamily | SET domain superfamily | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR46024 all species → | HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0003677 all species → | Molecular Function | DNA binding | Interproscan |
| GO:0005634 all species → | Cellular Component | nucleus | Interproscan |
| GO:0008270 all species → | Molecular Function | zinc ion binding | Interproscan |
| GO:0042054 all species → | Molecular Function | histone methyltransferase activity | Interproscan |
| GO:0005515 all species → | Molecular Function | protein binding | Interproscan |
| GO:0010629 all species → | Biological Process | negative regulation of gene expression | Interproscan |
| GO:0046974 all species → | Molecular Function | histone H3K9 methyltransferase activity | Interproscan |
| GO:0051567 all species → | Biological Process | obsolete histone H3-K9 methylation | Interproscan |
| GO:0070828 all species → | Biological Process | heterochromatin organization | Interproscan |
| GO:0090309 all species → | Biological Process | obsolete positive regulation of DNA methylation-dependent heterochromatin formation | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K11421 | SETDB1; [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase | EC:2.1.1.366 | Chromosome and associated proteins | ko03036 | deepkoala |
Transcript abundance of XP_065646369.1 across 60 RNA-seq samples of Hydra vulgaris. This gene has no row in the species' RNA-seq expression matrix, so every value below is shown as zero — the matrix simply does not cover this transcript. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| Regenerating head · dmso treatment | 18 | 0 | 0.00 | 0.00 | |
| Regenerating head · 25uM U0126 treatment | 15 | 0 | 0.00 | 0.00 | |
| Regenerating foot · dmso treatment | 9 | 0 | 0.00 | 0.00 | |
| Regenerating foot · 25uM U0126 treatment | 8 | 0 | 0.00 | 0.00 | |
| Regenerating head · u0126 treatment | 3 | 0 | 0.00 | 0.00 | |
| Whole animal · 25uM U0126 treatment | 3 | 0 | 0.00 | 0.00 | |
| Whole animal · dmso treatment | 3 | 0 | 0.00 | 0.00 | |
| Regenerating foot · u0126 treatment | 1 | 0 | 0.00 | 0.00 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR36435271 | Regenerating head · dmso treatment | Regenerating head | 12hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435272 | Regenerating head · dmso treatment | Regenerating head | 12hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435273 | Regenerating head · dmso treatment | Regenerating head | 12hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435277 | Regenerating head · dmso treatment | Regenerating head | 8hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435279 | Regenerating head · dmso treatment | Regenerating head | 8hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435280 | Regenerating head · dmso treatment | Regenerating head | 8hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435284 | Regenerating head · dmso treatment | Regenerating head | 0hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435285 | Regenerating head · dmso treatment | Regenerating head | 0hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435286 | Regenerating head · dmso treatment | Regenerating head | 0hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435304 | Regenerating head · dmso treatment | Regenerating head | 1.5hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435305 | Regenerating head · dmso treatment | Regenerating head | 1.5hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435306 | Regenerating head · dmso treatment | Regenerating head | 1.5hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435307 | Regenerating head · dmso treatment | Regenerating head | 3hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435308 | Regenerating head · dmso treatment | Regenerating head | 3hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435309 | Regenerating head · dmso treatment | Regenerating head | 3hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435310 | Regenerating head · dmso treatment | Regenerating head | 0hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435312 | Regenerating head · dmso treatment | Regenerating head | 0hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435313 | Regenerating head · dmso treatment | Regenerating head | 0hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435274 | Regenerating head · 25uM U0126 treatment | Regenerating head | 8hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435275 | Regenerating head · 25uM U0126 treatment | Regenerating head | 8hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435276 | Regenerating head · 25uM U0126 treatment | Regenerating head | 8hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435281 | Regenerating head · 25uM U0126 treatment | Regenerating head | 0hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435282 | Regenerating head · 25uM U0126 treatment | Regenerating head | 0hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435283 | Regenerating head · 25uM U0126 treatment | Regenerating head | 0hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435294 | Regenerating head · 25uM U0126 treatment | Regenerating head | 1.5hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435295 | Regenerating head · 25uM U0126 treatment | Regenerating head | 1.5hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435296 | Regenerating head · 25uM U0126 treatment | Regenerating head | 1.5hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435297 | Regenerating head · 25uM U0126 treatment | Regenerating head | 3hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435298 | Regenerating head · 25uM U0126 treatment | Regenerating head | 3hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435299 | Regenerating head · 25uM U0126 treatment | Regenerating head | 3hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435301 | Regenerating head · 25uM U0126 treatment | Regenerating head | 0hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435302 | Regenerating head · 25uM U0126 treatment | Regenerating head | 0hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435303 | Regenerating head · 25uM U0126 treatment | Regenerating head | 0hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435265 | Regenerating foot · dmso treatment | Regenerating foot | 1.5hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435266 | Regenerating foot · dmso treatment | Regenerating foot | 1.5hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435267 | Regenerating foot · dmso treatment | Regenerating foot | 1.5hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435278 | Regenerating foot · dmso treatment | Regenerating foot | 3hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435289 | Regenerating foot · dmso treatment | Regenerating foot | 3hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435300 | Regenerating foot · dmso treatment | Regenerating foot | 3hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435311 | Regenerating foot · dmso treatment | Regenerating foot | 0hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435322 | Regenerating foot · dmso treatment | Regenerating foot | 0hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435323 | Regenerating foot · dmso treatment | Regenerating foot | 0hpa | dmso treatment | SRP654941 | 0.00 |
| SRR36435314 | Regenerating foot · 25uM U0126 treatment | Regenerating foot | 1.5hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435315 | Regenerating foot · 25uM U0126 treatment | Regenerating foot | 1.5hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435316 | Regenerating foot · 25uM U0126 treatment | Regenerating foot | 1.5hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435317 | Regenerating foot · 25uM U0126 treatment | Regenerating foot | 3hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435318 | Regenerating foot · 25uM U0126 treatment | Regenerating foot | 3hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435319 | Regenerating foot · 25uM U0126 treatment | Regenerating foot | 3hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435320 | Regenerating foot · 25uM U0126 treatment | Regenerating foot | 0hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435321 | Regenerating foot · 25uM U0126 treatment | Regenerating foot | 0hpa | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435268 | Regenerating head · u0126 treatment | Regenerating head | 12hpa | u0126 treatment | SRP654941 | 0.00 |
| SRR36435269 | Regenerating head · u0126 treatment | Regenerating head | 12hpa | u0126 treatment | SRP654941 | 0.00 |
| SRR36435270 | Regenerating head · u0126 treatment | Regenerating head | 12hpa | u0126 treatment | SRP654941 | 0.00 |
| SRR36435287 | Whole animal · 25uM U0126 treatment | Whole animal | 12h | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435288 | Whole animal · 25uM U0126 treatment | Whole animal | 12h | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435290 | Whole animal · 25uM U0126 treatment | Whole animal | 12h | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435291 | Whole animal · dmso treatment | Whole animal | 12h | dmso treatment | SRP654941 | 0.00 |
| SRR36435292 | Whole animal · dmso treatment | Whole animal | 12h | dmso treatment | SRP654941 | 0.00 |
| SRR36435293 | Whole animal · dmso treatment | Whole animal | 12h | dmso treatment | SRP654941 | 0.00 |
| SRR36435264 | Regenerating foot · u0126 treatment | Regenerating foot | 0hpa | u0126 treatment | SRP654941 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (HVULG_TPM,
StringTie quantification over 60 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Hydra vulgaris tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 0 | not in this network | - |
| Negatively correlated | 0 | not in this network | - |
This gene has no edge at all in the Hydra vulgaris network, in either direction — it is not one of the genes the network was built from (the network covers genes with enough expression variation across the transcriptome samples). The counts above are a property of the network, not a failed lookup.
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Hydra vulgaris, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
| Dataset | Tissue / stage | Cells | Cell types | This gene | Marker of |
|---|---|---|---|---|---|
| HVULG_siebert_atlas | Whole animals · Adult (whole animal) | 25,438 | 42 | not in this dataset | – |
A gene is in viewer when the dataset ships a per-cell expression vector for it; marker only means it is in the dataset’s ranked marker table but no vector was exported, so the atlas cannot draw it; not in this dataset means the dataset’s own gene-ID table does not list it, so no expression claim can be made for that dataset. unmapped is deliberately weaker still: the dataset has no gene-ID table on CnidoSite yet, so nothing is claimed in either direction. Where markers are listed, the numbers are log2 fold change and the percentage of cells of that type in which the gene was detected.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
| Assay | Sample | Peaks | Region |
|---|
No called peak overlaps this gene in 1 available assay. Either the gene is not near an accessible or marked region in those samples, or it is not represented in the peak caller’s annotation.
Browse the full epigenomic landscape of this species: ChIP-seq.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | no expression matrix | – |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |