Genomic Location: NC_088922.1:55419573...55482075
NR annotation: XP_047129241.1, sodium/potassium-transporting ATPase subunit alpha-like [Hydra vulgaris]
Species Hydra vulgaris · all data for this species · gene families
| CDS |
| LOC100209230 |
| Transcript |
| rna-XM_065793729.1 |
| Protein |
| XP_065649801.1 |
| UniProt accession | Description |
|---|---|
| P35317 | Sodium/potassium-transporting ATPase subunit alpha OS=Hydra vulgaris OX=6087 PE=2 SV=1 |
| P24798 | Sodium/potassium-transporting ATPase subunit alpha-3 OS=Gallus gallus OX=9031 GN=ATP1A3 PE=2 SV=1 |
| Q6PIC6 | Sodium/potassium-transporting ATPase subunit alpha-3 OS=Mus musculus OX=10090 GN=Atp1a3 PE=1 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0001595 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00690 all species → | Cation_ATPase_N | Cation transporter/ATPase, N-terminus | Domain | Interproscan |
| PF00689 all species → | Cation_ATPase_C | Cation transporting ATPase, C-terminus | Family | Interproscan |
| PF13246 all species → | Cation_ATPase | Cation transport ATPase (P-type) | Family | Interproscan |
| PF00122 all species → | E1-E2_ATPase | E1-E2 ATPase | Family | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR023299 all species → | Homologous_superfamily | P-type ATPase, cytoplasmic domain N | Interproscan |
| IPR005775 all species → | Family | P-type ATPase subfamily IIC, subunit alpha | Interproscan |
| IPR004014 all species → | Domain | Cation-transporting P-type ATPase, N-terminal | Interproscan |
| IPR044492 all species → | Domain | P-type ATPase, haloacid dehalogenase domain | Interproscan |
| IPR036412 all species → | Homologous_superfamily | HAD-like superfamily | Interproscan |
| IPR006068 all species → | Domain | Cation-transporting P-type ATPase, C-terminal | Interproscan |
| IPR008250 all species → | Homologous_superfamily | P-type ATPase, A domain superfamily | Interproscan |
| IPR023214 all species → | Homologous_superfamily | HAD superfamily | Interproscan |
| IPR050510 all species → | Family | Cation transport ATPase (P-type) | Interproscan |
| IPR001757 all species → | Family | P-type ATPase | Interproscan |
| IPR018303 all species → | PTM | P-type ATPase, phosphorylation site | Interproscan |
| IPR023298 all species → | Homologous_superfamily | P-type ATPase, transmembrane domain superfamily | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR43294 all species → | SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0000166 all species → | Molecular Function | nucleotide binding | Interproscan |
| GO:0005524 all species → | Molecular Function | ATP binding | Interproscan |
| GO:0006813 all species → | Biological Process | potassium ion transport | Interproscan |
| GO:0008556 all species → | Molecular Function | P-type potassium transmembrane transporter activity | Interproscan |
| GO:0016020 all species → | Cellular Component | membrane | Interproscan |
| GO:0005391 all species → | Molecular Function | P-type sodium:potassium-exchanging transporter activity | Interproscan |
| GO:0005886 all species → | Cellular Component | plasma membrane | Interproscan |
| GO:0006883 all species → | Biological Process | intracellular sodium ion homeostasis | Interproscan |
| GO:0019829 all species → | Molecular Function | ATPase-coupled monoatomic cation transmembrane transporter activity | Interproscan |
| GO:0030007 all species → | Biological Process | intracellular potassium ion homeostasis | Interproscan |
| GO:0036376 all species → | Biological Process | sodium ion export across plasma membrane | Interproscan |
| GO:1902600 all species → | Biological Process | proton transmembrane transport | Interproscan |
| GO:1990573 all species → | Biological Process | potassium ion import across plasma membrane | Interproscan |
| GO:0005215 all species → | Molecular Function | transporter activity | Interproscan |
| GO:0016887 all species → | Molecular Function | ATP hydrolysis activity | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K01539 | ATP1A; sodium/potassium-transporting ATPase subunit alpha | EC:7.2.2.13 | Exosome | ko04147 | deepkoala |
Transcript abundance of XP_065649801.1 across 60 RNA-seq samples of Hydra vulgaris. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| Regenerating head · dmso treatment | 18 | 18 | 0.23 | 0.62 | |
| Regenerating head · 25uM U0126 treatment | 15 | 15 | 0.19 | 0.43 | |
| Regenerating foot · dmso treatment | 9 | 9 | 0.44 | 0.85 | |
| Regenerating foot · 25uM U0126 treatment | 8 | 8 | 0.32 | 0.58 | |
| Regenerating head · u0126 treatment | 3 | 3 | 0.25 | 0.35 | |
| Whole animal · 25uM U0126 treatment | 3 | 2 | 0.15 | 0.23 | |
| Whole animal · dmso treatment | 3 | 2 | 0.19 | 0.30 | |
| Regenerating foot · u0126 treatment | 1 | 1 | 0.28 | 0.28 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR36435285 | Regenerating head · dmso treatment | Regenerating head | 0hpa | dmso treatment | SRP654941 | 0.62 |
| SRR36435305 | Regenerating head · dmso treatment | Regenerating head | 1.5hpa | dmso treatment | SRP654941 | 0.43 |
| SRR36435309 | Regenerating head · dmso treatment | Regenerating head | 3hpa | dmso treatment | SRP654941 | 0.39 |
| SRR36435279 | Regenerating head · dmso treatment | Regenerating head | 8hpa | dmso treatment | SRP654941 | 0.35 |
| SRR36435306 | Regenerating head · dmso treatment | Regenerating head | 1.5hpa | dmso treatment | SRP654941 | 0.34 |
| SRR36435304 | Regenerating head · dmso treatment | Regenerating head | 1.5hpa | dmso treatment | SRP654941 | 0.31 |
| SRR36435307 | Regenerating head · dmso treatment | Regenerating head | 3hpa | dmso treatment | SRP654941 | 0.24 |
| SRR36435310 | Regenerating head · dmso treatment | Regenerating head | 0hpa | dmso treatment | SRP654941 | 0.20 |
| SRR36435272 | Regenerating head · dmso treatment | Regenerating head | 12hpa | dmso treatment | SRP654941 | 0.20 |
| SRR36435308 | Regenerating head · dmso treatment | Regenerating head | 3hpa | dmso treatment | SRP654941 | 0.18 |
| SRR36435313 | Regenerating head · dmso treatment | Regenerating head | 0hpa | dmso treatment | SRP654941 | 0.16 |
| SRR36435280 | Regenerating head · dmso treatment | Regenerating head | 8hpa | dmso treatment | SRP654941 | 0.16 |
| SRR36435312 | Regenerating head · dmso treatment | Regenerating head | 0hpa | dmso treatment | SRP654941 | 0.15 |
| SRR36435286 | Regenerating head · dmso treatment | Regenerating head | 0hpa | dmso treatment | SRP654941 | 0.14 |
| SRR36435271 | Regenerating head · dmso treatment | Regenerating head | 12hpa | dmso treatment | SRP654941 | 0.12 |
| SRR36435284 | Regenerating head · dmso treatment | Regenerating head | 0hpa | dmso treatment | SRP654941 | 0.08 |
| SRR36435277 | Regenerating head · dmso treatment | Regenerating head | 8hpa | dmso treatment | SRP654941 | 0.07 |
| SRR36435273 | Regenerating head · dmso treatment | Regenerating head | 12hpa | dmso treatment | SRP654941 | 0.06 |
| SRR36435283 | Regenerating head · 25uM U0126 treatment | Regenerating head | 0hpa | 25uM U0126 treatment | SRP654941 | 0.43 |
| SRR36435282 | Regenerating head · 25uM U0126 treatment | Regenerating head | 0hpa | 25uM U0126 treatment | SRP654941 | 0.34 |
| SRR36435276 | Regenerating head · 25uM U0126 treatment | Regenerating head | 8hpa | 25uM U0126 treatment | SRP654941 | 0.34 |
| SRR36435295 | Regenerating head · 25uM U0126 treatment | Regenerating head | 1.5hpa | 25uM U0126 treatment | SRP654941 | 0.31 |
| SRR36435296 | Regenerating head · 25uM U0126 treatment | Regenerating head | 1.5hpa | 25uM U0126 treatment | SRP654941 | 0.23 |
| SRR36435303 | Regenerating head · 25uM U0126 treatment | Regenerating head | 0hpa | 25uM U0126 treatment | SRP654941 | 0.18 |
| SRR36435297 | Regenerating head · 25uM U0126 treatment | Regenerating head | 3hpa | 25uM U0126 treatment | SRP654941 | 0.18 |
| SRR36435298 | Regenerating head · 25uM U0126 treatment | Regenerating head | 3hpa | 25uM U0126 treatment | SRP654941 | 0.15 |
| SRR36435274 | Regenerating head · 25uM U0126 treatment | Regenerating head | 8hpa | 25uM U0126 treatment | SRP654941 | 0.15 |
| SRR36435275 | Regenerating head · 25uM U0126 treatment | Regenerating head | 8hpa | 25uM U0126 treatment | SRP654941 | 0.15 |
| SRR36435294 | Regenerating head · 25uM U0126 treatment | Regenerating head | 1.5hpa | 25uM U0126 treatment | SRP654941 | 0.13 |
| SRR36435301 | Regenerating head · 25uM U0126 treatment | Regenerating head | 0hpa | 25uM U0126 treatment | SRP654941 | 0.08 |
| SRR36435281 | Regenerating head · 25uM U0126 treatment | Regenerating head | 0hpa | 25uM U0126 treatment | SRP654941 | 0.08 |
| SRR36435299 | Regenerating head · 25uM U0126 treatment | Regenerating head | 3hpa | 25uM U0126 treatment | SRP654941 | 0.07 |
| SRR36435302 | Regenerating head · 25uM U0126 treatment | Regenerating head | 0hpa | 25uM U0126 treatment | SRP654941 | 0.05 |
| SRR36435267 | Regenerating foot · dmso treatment | Regenerating foot | 1.5hpa | dmso treatment | SRP654941 | 0.85 |
| SRR36435322 | Regenerating foot · dmso treatment | Regenerating foot | 0hpa | dmso treatment | SRP654941 | 0.67 |
| SRR36435300 | Regenerating foot · dmso treatment | Regenerating foot | 3hpa | dmso treatment | SRP654941 | 0.51 |
| SRR36435323 | Regenerating foot · dmso treatment | Regenerating foot | 0hpa | dmso treatment | SRP654941 | 0.44 |
| SRR36435289 | Regenerating foot · dmso treatment | Regenerating foot | 3hpa | dmso treatment | SRP654941 | 0.34 |
| SRR36435278 | Regenerating foot · dmso treatment | Regenerating foot | 3hpa | dmso treatment | SRP654941 | 0.33 |
| SRR36435266 | Regenerating foot · dmso treatment | Regenerating foot | 1.5hpa | dmso treatment | SRP654941 | 0.31 |
| SRR36435311 | Regenerating foot · dmso treatment | Regenerating foot | 0hpa | dmso treatment | SRP654941 | 0.25 |
| SRR36435265 | Regenerating foot · dmso treatment | Regenerating foot | 1.5hpa | dmso treatment | SRP654941 | 0.24 |
| SRR36435318 | Regenerating foot · 25uM U0126 treatment | Regenerating foot | 3hpa | 25uM U0126 treatment | SRP654941 | 0.58 |
| SRR36435314 | Regenerating foot · 25uM U0126 treatment | Regenerating foot | 1.5hpa | 25uM U0126 treatment | SRP654941 | 0.52 |
| SRR36435319 | Regenerating foot · 25uM U0126 treatment | Regenerating foot | 3hpa | 25uM U0126 treatment | SRP654941 | 0.36 |
| SRR36435321 | Regenerating foot · 25uM U0126 treatment | Regenerating foot | 0hpa | 25uM U0126 treatment | SRP654941 | 0.26 |
| SRR36435320 | Regenerating foot · 25uM U0126 treatment | Regenerating foot | 0hpa | 25uM U0126 treatment | SRP654941 | 0.24 |
| SRR36435316 | Regenerating foot · 25uM U0126 treatment | Regenerating foot | 1.5hpa | 25uM U0126 treatment | SRP654941 | 0.21 |
| SRR36435315 | Regenerating foot · 25uM U0126 treatment | Regenerating foot | 1.5hpa | 25uM U0126 treatment | SRP654941 | 0.21 |
| SRR36435317 | Regenerating foot · 25uM U0126 treatment | Regenerating foot | 3hpa | 25uM U0126 treatment | SRP654941 | 0.16 |
| SRR36435270 | Regenerating head · u0126 treatment | Regenerating head | 12hpa | u0126 treatment | SRP654941 | 0.35 |
| SRR36435269 | Regenerating head · u0126 treatment | Regenerating head | 12hpa | u0126 treatment | SRP654941 | 0.24 |
| SRR36435268 | Regenerating head · u0126 treatment | Regenerating head | 12hpa | u0126 treatment | SRP654941 | 0.16 |
| SRR36435288 | Whole animal · 25uM U0126 treatment | Whole animal | 12h | 25uM U0126 treatment | SRP654941 | 0.23 |
| SRR36435290 | Whole animal · 25uM U0126 treatment | Whole animal | 12h | 25uM U0126 treatment | SRP654941 | 0.21 |
| SRR36435287 | Whole animal · 25uM U0126 treatment | Whole animal | 12h | 25uM U0126 treatment | SRP654941 | 0.00 |
| SRR36435293 | Whole animal · dmso treatment | Whole animal | 12h | dmso treatment | SRP654941 | 0.30 |
| SRR36435292 | Whole animal · dmso treatment | Whole animal | 12h | dmso treatment | SRP654941 | 0.25 |
| SRR36435291 | Whole animal · dmso treatment | Whole animal | 12h | dmso treatment | SRP654941 | 0.00 |
| SRR36435264 | Regenerating foot · u0126 treatment | Regenerating foot | 0hpa | u0126 treatment | SRP654941 | 0.28 |
Source: CnidoSite RNA-seq expression matrices (HVULG_TPM,
StringTie quantification over 60 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Hydra vulgaris tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 1 | XP_065663165.1 | 0.717685616191808 |
| Negatively correlated | 7 | XP_065648527.1 | -0.536754123773105 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Hydra vulgaris, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
| Dataset | Tissue / stage | Cells | Cell types | This gene | Marker of |
|---|---|---|---|---|---|
| HVULG_siebert_atlas | Whole animals · Adult (whole animal) | 25,438 | 42 | not in this dataset | – |
A gene is in viewer when the dataset ships a per-cell expression vector for it; marker only means it is in the dataset’s ranked marker table but no vector was exported, so the atlas cannot draw it; not in this dataset means the dataset’s own gene-ID table does not list it, so no expression claim can be made for that dataset. unmapped is deliberately weaker still: the dataset has no gene-ID table on CnidoSite yet, so nothing is claimed in either direction. Where markers are listed, the numbers are log2 fold change and the percentage of cells of that type in which the gene was detected.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
| Assay | Sample | Peaks | Region |
|---|---|---|---|
| ChIP-seq | H3K27ac_regenerating_head_0hr | 1 | Intron 1 |
| H3K27ac_regenerating_head_6hr | 1 | Intron 1 | |
| H3K27ac_wholeAnimal | 2 | Distal Intergenic 1 · Intron 1 | |
| H3K4me2_regenerating_head_0hr | 1 | Intron 1 | |
| H3K4me2_regenerating_head_24hr | 2 | Intron 2 | |
| H3K4me2_regenerating_head_4hr | 1 | Intron 1 | |
| H3K4me2_regenerating_head_6hr | 1 | Intron 1 | |
| H3K4me2_wholeAnimal | 1 | Promoter (2-3kb) 1 | |
| H3K4me3_regenerating_head_4hr | 1 | Intron 1 | |
| H3K4me3_regenerating_head_6hr | 1 | Intron 1 | |
| H3K4me3_wholeAnimal | 3 | Intron 3 | |
| H4K20me1_regenerating_tips_12hrs | 4 | Intron 2 · Distal Intergenic 1 · Exon 1 | |
| H4K20me1_regenerating_tips_8hrs | 5 | Intron 3 · Exon 2 | |
| H4K20me1_whole_polyp_ALP_treated | 5 | Distal Intergenic 3 · Intron 2 |
Browse the full epigenomic landscape of this species: ChIP-seq.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |