Detailed information of XP_065670370.1 in Hydra vulgaris

Genomic Location: NC_088931.1:71185008...71224277
NR annotation: XP_047145552.1, dual serine/threonine and tyrosine protein kinase [Hydra vulgaris]
Species Hydra vulgaris · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
Q6XUX0Dual serine/threonine and tyrosine protein kinase OS=Gallus gallus OX=9031 GN=DSTYK PE=2 SV=1
Q4VSN4Dual serine/threonine and tyrosine protein kinase OS=Canis lupus familiaris OX=9615 GN=DSTYK PE=2 SV=1
Q67E00Dual serine/threonine and tyrosine protein kinase OS=Xenopus tropicalis OX=8364 GN=dstyk PE=2 SV=1
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0005766 (this species only) · gene tree & orthology

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF00069
all species →
PkinaseProtein kinase domainDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR000719
all species →
DomainProtein kinase domainInterproscan
IPR011009
all species →
Homologous_superfamilyProtein kinase-like domain superfamilyInterproscan
IPR008271
all species →
Active_siteSerine/threonine-protein kinase, active siteInterproscan
IPR051302
all species →
FamilyDual Ser/Thr and Tyr Protein KinaseInterproscan
IPR017441
all species →
Binding_siteProtein kinase, ATP binding siteInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR46392
all species →
DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASEInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0004672
all species →
Molecular Functionprotein kinase activityInterproscan
GO:0005524
all species →
Molecular FunctionATP bindingInterproscan
GO:0006468
all species →
Biological Processprotein phosphorylationInterproscan
GO:0005737
all species →
Cellular ComponentcytoplasmInterproscan
GO:0043066
all species →
Biological Processnegative regulation of apoptotic processInterproscan
GO:0044344
all species →
Biological Processcellular response to fibroblast growth factor stimulusInterproscan
GO:0045743
all species →
Biological Processpositive regulation of fibroblast growth factor receptor signaling pathwayInterproscan
GO:0070374
all species →
Biological Processpositive regulation of ERK1 and ERK2 cascadeInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K16288DSTYK, RIPK5; dual serine/threonine and tyrosine protein kinaseEC:2.7.12.1
Protein kinasesko01001deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_065670370.1 across 60 RNA-seq samples of Hydra vulgaris. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

60Samples
60TPM > 0
8Conditions
22.9Max TPM
14.8Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
Regenerating head · dmso treatment 18 18 15.15 22.87
Regenerating head · 25uM U0126 treatment 15 15 15.35 20.80
Regenerating foot · dmso treatment 9 9 13.36 17.43
Regenerating foot · 25uM U0126 treatment 8 8 12.58 15.64
Regenerating head · u0126 treatment 3 3 12.26 13.25
Whole animal · 25uM U0126 treatment 3 3 17.89 20.97
Whole animal · dmso treatment 3 3 18.32 19.05
Regenerating foot · u0126 treatment 1 1 18.51 18.51

Per sample · hover a bar for the full sample record

Show the sample table (60 samples)
SRA runConditionTissueDevelopmental stage TreatmentStudyTPM
SRR36435286 Regenerating head · dmso treatment Regenerating head 0hpa dmso treatment SRP654941 22.87
SRR36435285 Regenerating head · dmso treatment Regenerating head 0hpa dmso treatment SRP654941 18.85
SRR36435284 Regenerating head · dmso treatment Regenerating head 0hpa dmso treatment SRP654941 18.77
SRR36435313 Regenerating head · dmso treatment Regenerating head 0hpa dmso treatment SRP654941 17.57
SRR36435310 Regenerating head · dmso treatment Regenerating head 0hpa dmso treatment SRP654941 16.18
SRR36435304 Regenerating head · dmso treatment Regenerating head 1.5hpa dmso treatment SRP654941 15.40
SRR36435305 Regenerating head · dmso treatment Regenerating head 1.5hpa dmso treatment SRP654941 15.37
SRR36435279 Regenerating head · dmso treatment Regenerating head 8hpa dmso treatment SRP654941 15.15
SRR36435306 Regenerating head · dmso treatment Regenerating head 1.5hpa dmso treatment SRP654941 14.95
SRR36435308 Regenerating head · dmso treatment Regenerating head 3hpa dmso treatment SRP654941 14.76
SRR36435307 Regenerating head · dmso treatment Regenerating head 3hpa dmso treatment SRP654941 14.62
SRR36435273 Regenerating head · dmso treatment Regenerating head 12hpa dmso treatment SRP654941 14.62
SRR36435272 Regenerating head · dmso treatment Regenerating head 12hpa dmso treatment SRP654941 13.57
SRR36435309 Regenerating head · dmso treatment Regenerating head 3hpa dmso treatment SRP654941 13.49
SRR36435280 Regenerating head · dmso treatment Regenerating head 8hpa dmso treatment SRP654941 13.43
SRR36435277 Regenerating head · dmso treatment Regenerating head 8hpa dmso treatment SRP654941 12.19
SRR36435312 Regenerating head · dmso treatment Regenerating head 0hpa dmso treatment SRP654941 11.17
SRR36435271 Regenerating head · dmso treatment Regenerating head 12hpa dmso treatment SRP654941 9.78
SRR36435303 Regenerating head · 25uM U0126 treatment Regenerating head 0hpa 25uM U0126 treatment SRP654941 20.80
SRR36435282 Regenerating head · 25uM U0126 treatment Regenerating head 0hpa 25uM U0126 treatment SRP654941 20.16
SRR36435281 Regenerating head · 25uM U0126 treatment Regenerating head 0hpa 25uM U0126 treatment SRP654941 18.34
SRR36435296 Regenerating head · 25uM U0126 treatment Regenerating head 1.5hpa 25uM U0126 treatment SRP654941 16.23
SRR36435301 Regenerating head · 25uM U0126 treatment Regenerating head 0hpa 25uM U0126 treatment SRP654941 15.82
SRR36435283 Regenerating head · 25uM U0126 treatment Regenerating head 0hpa 25uM U0126 treatment SRP654941 15.76
SRR36435295 Regenerating head · 25uM U0126 treatment Regenerating head 1.5hpa 25uM U0126 treatment SRP654941 15.71
SRR36435302 Regenerating head · 25uM U0126 treatment Regenerating head 0hpa 25uM U0126 treatment SRP654941 15.33
SRR36435299 Regenerating head · 25uM U0126 treatment Regenerating head 3hpa 25uM U0126 treatment SRP654941 14.80
SRR36435275 Regenerating head · 25uM U0126 treatment Regenerating head 8hpa 25uM U0126 treatment SRP654941 14.79
SRR36435294 Regenerating head · 25uM U0126 treatment Regenerating head 1.5hpa 25uM U0126 treatment SRP654941 14.36
SRR36435298 Regenerating head · 25uM U0126 treatment Regenerating head 3hpa 25uM U0126 treatment SRP654941 13.29
SRR36435297 Regenerating head · 25uM U0126 treatment Regenerating head 3hpa 25uM U0126 treatment SRP654941 12.79
SRR36435274 Regenerating head · 25uM U0126 treatment Regenerating head 8hpa 25uM U0126 treatment SRP654941 12.46
SRR36435276 Regenerating head · 25uM U0126 treatment Regenerating head 8hpa 25uM U0126 treatment SRP654941 9.56
SRR36435265 Regenerating foot · dmso treatment Regenerating foot 1.5hpa dmso treatment SRP654941 17.43
SRR36435322 Regenerating foot · dmso treatment Regenerating foot 0hpa dmso treatment SRP654941 16.40
SRR36435266 Regenerating foot · dmso treatment Regenerating foot 1.5hpa dmso treatment SRP654941 15.60
SRR36435323 Regenerating foot · dmso treatment Regenerating foot 0hpa dmso treatment SRP654941 13.20
SRR36435289 Regenerating foot · dmso treatment Regenerating foot 3hpa dmso treatment SRP654941 12.79
SRR36435267 Regenerating foot · dmso treatment Regenerating foot 1.5hpa dmso treatment SRP654941 12.42
SRR36435278 Regenerating foot · dmso treatment Regenerating foot 3hpa dmso treatment SRP654941 11.91
SRR36435311 Regenerating foot · dmso treatment Regenerating foot 0hpa dmso treatment SRP654941 11.19
SRR36435300 Regenerating foot · dmso treatment Regenerating foot 3hpa dmso treatment SRP654941 9.34
SRR36435321 Regenerating foot · 25uM U0126 treatment Regenerating foot 0hpa 25uM U0126 treatment SRP654941 15.64
SRR36435316 Regenerating foot · 25uM U0126 treatment Regenerating foot 1.5hpa 25uM U0126 treatment SRP654941 13.51
SRR36435320 Regenerating foot · 25uM U0126 treatment Regenerating foot 0hpa 25uM U0126 treatment SRP654941 13.14
SRR36435315 Regenerating foot · 25uM U0126 treatment Regenerating foot 1.5hpa 25uM U0126 treatment SRP654941 13.12
SRR36435317 Regenerating foot · 25uM U0126 treatment Regenerating foot 3hpa 25uM U0126 treatment SRP654941 12.20
SRR36435314 Regenerating foot · 25uM U0126 treatment Regenerating foot 1.5hpa 25uM U0126 treatment SRP654941 11.94
SRR36435318 Regenerating foot · 25uM U0126 treatment Regenerating foot 3hpa 25uM U0126 treatment SRP654941 11.70
SRR36435319 Regenerating foot · 25uM U0126 treatment Regenerating foot 3hpa 25uM U0126 treatment SRP654941 9.37
SRR36435268 Regenerating head · u0126 treatment Regenerating head 12hpa u0126 treatment SRP654941 13.25
SRR36435270 Regenerating head · u0126 treatment Regenerating head 12hpa u0126 treatment SRP654941 12.81
SRR36435269 Regenerating head · u0126 treatment Regenerating head 12hpa u0126 treatment SRP654941 10.73
SRR36435290 Whole animal · 25uM U0126 treatment Whole animal 12h 25uM U0126 treatment SRP654941 20.97
SRR36435288 Whole animal · 25uM U0126 treatment Whole animal 12h 25uM U0126 treatment SRP654941 16.60
SRR36435287 Whole animal · 25uM U0126 treatment Whole animal 12h 25uM U0126 treatment SRP654941 16.09
SRR36435292 Whole animal · dmso treatment Whole animal 12h dmso treatment SRP654941 19.05
SRR36435291 Whole animal · dmso treatment Whole animal 12h dmso treatment SRP654941 18.71
SRR36435293 Whole animal · dmso treatment Whole animal 12h dmso treatment SRP654941 17.19
SRR36435264 Regenerating foot · u0126 treatment Regenerating foot 0hpa u0126 treatment SRP654941 18.51

Source: CnidoSite RNA-seq expression matrices (HVULG_TPM, StringTie quantification over 60 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Hydra vulgaris tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

DirectionPartnersMost correlated partnerPCC
Positively correlated14XP_065670749.10.822145724612782
Negatively correlated9XP_065675925.1-0.708673280569115

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Hydra vulgaris, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

DatasetTissue / stageCellsCell typesThis geneMarker of
HVULG_siebert_atlasWhole animals · Adult (whole animal)25,43842not in this dataset

A gene is in viewer when the dataset ships a per-cell expression vector for it; marker only means it is in the dataset’s ranked marker table but no vector was exported, so the atlas cannot draw it; not in this dataset means the dataset’s own gene-ID table does not list it, so no expression claim can be made for that dataset. unmapped is deliberately weaker still: the dataset has no gene-ID table on CnidoSite yet, so nothing is claimed in either direction. Where markers are listed, the numbers are log2 fold change and the percentage of cells of that type in which the gene was detected.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

Peak calls overlapping this gene

AssaySamplePeaksRegion
ChIP-seqH3K27ac_regenerating_head_0hr2Promoter (<=1kb) 1 · Distal Intergenic 1
H3K27ac_regenerating_head_24hr1Promoter (<=1kb) 1
H3K27ac_regenerating_head_4hr1Promoter (<=1kb) 1
H3K27ac_regenerating_head_6hr1Promoter (<=1kb) 1
H3K4me2_regenerating_head_0hr3Distal Intergenic 3
H3K4me2_regenerating_head_24hr4Distal Intergenic 3 · Intron 1
H3K4me2_regenerating_head_4hr3Distal Intergenic 3
H3K4me2_regenerating_head_6hr3Distal Intergenic 3
H3K4me2_wholeAnimal2Distal Intergenic 2
H3K4me3_regenerating_head_0hr3Distal Intergenic 3
H3K4me3_regenerating_head_24hr1Distal Intergenic 1
H3K4me3_regenerating_head_4hr1Distal Intergenic 1
H3K4me3_whole_polyp_24hr_DMSO_control1Distal Intergenic 1
H3K4me3_wholeAnimal1Distal Intergenic 1
H4K20me1_regenerating_tips_12hrs1Intron 1

2 further sample(s) also have peaks at this gene; open the assay page below to see them all.

Browse the full epigenomic landscape of this species: ChIP-seq.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.readyopen →
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
TOP