Detailed information of XP_065673456.1 in Hydra vulgaris

Genomic Location: NC_088933.1:6323401...6392273
NR annotation: XP_047145987.1, DNA polymerase delta catalytic subunit [Hydra vulgaris]
Species Hydra vulgaris · all data for this species · gene families


 Gene Structure
More details in JBrowse  Sequence
CDS
Transcript
Protein
 UniProt (Swiss-Prot top hit)
UniProt accessionDescription
P54358DNA polymerase delta catalytic subunit OS=Drosophila melanogaster OX=7227 GN=PolD1 PE=1 SV=2
P97283DNA polymerase delta catalytic subunit OS=Mesocricetus auratus OX=10036 GN=POLD1 PE=2 SV=1
P52431DNA polymerase delta catalytic subunit OS=Mus musculus OX=10090 GN=Pold1 PE=1 SV=2
 Gene family
Family typeMembership / link
Orthogroup (gene family)OG0003830 (this species only) · gene tree & orthology

 Pfam domain
Pfam accessionPfam nameDescriptionTypeSource
PF00136
all species →
DNA_pol_BDNA polymerase family BFamilyInterproscan
PF03104
all species →
DNA_pol_B_exo1DNA polymerase family B, exonuclease domainFamilyInterproscan
PF14260
all species →
zf-C4polC4-type zinc-finger of DNA polymerase deltaDomainInterproscan

 InterPro
InterPro termTypeDescriptionSource
IPR023211
all species →
Homologous_superfamilyDNA polymerase, palm domain superfamilyInterproscan
IPR036397
all species →
Homologous_superfamilyRibonuclease H superfamilyInterproscan
IPR050240
all species →
FamilyDNA polymerase type-BInterproscan
IPR006134
all species →
DomainDNA-directed DNA polymerase, family B, multifunctional domainInterproscan
IPR006133
all species →
DomainDNA-directed DNA polymerase, family B, exonuclease domainInterproscan
IPR042087
all species →
Homologous_superfamilyDNA polymerase family B, thumb domainInterproscan
IPR017964
all species →
Conserved_siteDNA-directed DNA polymerase, family B, conserved siteInterproscan
IPR043502
all species →
Homologous_superfamilyDNA/RNA polymerase superfamilyInterproscan
IPR012337
all species →
Homologous_superfamilyRibonuclease H-like superfamilyInterproscan
IPR006172
all species →
FamilyDNA-directed DNA polymerase, family BInterproscan
IPR025687
all species →
DomainC4-type zinc-finger of DNA polymerase deltaInterproscan

 PANTHER
PANTHER termDescriptionSource
PTHR10322
all species →
DNA POLYMERASE CATALYTIC SUBUNITInterproscan

 Gene Ontology
GO termCategoryDescriptionSource
GO:0003676
all species →
Molecular Functionnucleic acid bindingInterproscan
GO:0003887
all species →
Molecular FunctionDNA-directed DNA polymerase activityInterproscan
GO:0006261
all species →
Biological ProcessDNA-templated DNA replicationInterproscan
GO:0006287
all species →
Biological Processbase-excision repair, gap-fillingInterproscan
GO:0006297
all species →
Biological Processnucleotide-excision repair, DNA gap fillingInterproscan
GO:0008296
all species →
Molecular Function3'-5'-DNA exonuclease activityInterproscan
GO:0043625
all species →
Cellular Componentdelta DNA polymerase complexInterproscan
GO:0045004
all species →
Biological ProcessDNA replication proofreadingInterproscan
GO:0000166
all species →
Molecular Functionnucleotide bindingInterproscan
GO:0003677
all species →
Molecular FunctionDNA bindingInterproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.
 KEGG pathway
KOEnzymeEnzyme IDPathwayMap IDSource
K02327POLD1; DNA polymerase delta subunit 1EC:2.7.7.7
DNA repair and recombination proteinsko03400deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of XP_065673456.1 across 60 RNA-seq samples of Hydra vulgaris. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

60Samples
60TPM > 0
8Conditions
28.0Max TPM
19.6Mean TPM

By condition

ConditionSamplesTPM > 0 Mean TPMMax TPMMean, relative to max
Regenerating head · dmso treatment 18 18 18.75 25.91
Regenerating head · 25uM U0126 treatment 15 15 18.95 28.05
Regenerating foot · dmso treatment 9 9 19.85 25.97
Regenerating foot · 25uM U0126 treatment 8 8 20.10 22.83
Regenerating head · u0126 treatment 3 3 19.09 20.70
Whole animal · 25uM U0126 treatment 3 3 23.36 23.77
Whole animal · dmso treatment 3 3 22.11 23.71
Regenerating foot · u0126 treatment 1 1 20.71 20.71

Per sample · hover a bar for the full sample record

Show the sample table (60 samples)
SRA runConditionTissueDevelopmental stage TreatmentStudyTPM
SRR36435285 Regenerating head · dmso treatment Regenerating head 0hpa dmso treatment SRP654941 25.91
SRR36435284 Regenerating head · dmso treatment Regenerating head 0hpa dmso treatment SRP654941 25.48
SRR36435286 Regenerating head · dmso treatment Regenerating head 0hpa dmso treatment SRP654941 22.73
SRR36435309 Regenerating head · dmso treatment Regenerating head 3hpa dmso treatment SRP654941 21.97
SRR36435308 Regenerating head · dmso treatment Regenerating head 3hpa dmso treatment SRP654941 20.96
SRR36435306 Regenerating head · dmso treatment Regenerating head 1.5hpa dmso treatment SRP654941 20.91
SRR36435272 Regenerating head · dmso treatment Regenerating head 12hpa dmso treatment SRP654941 20.70
SRR36435304 Regenerating head · dmso treatment Regenerating head 1.5hpa dmso treatment SRP654941 19.30
SRR36435307 Regenerating head · dmso treatment Regenerating head 3hpa dmso treatment SRP654941 19.05
SRR36435313 Regenerating head · dmso treatment Regenerating head 0hpa dmso treatment SRP654941 18.11
SRR36435273 Regenerating head · dmso treatment Regenerating head 12hpa dmso treatment SRP654941 17.91
SRR36435277 Regenerating head · dmso treatment Regenerating head 8hpa dmso treatment SRP654941 17.87
SRR36435279 Regenerating head · dmso treatment Regenerating head 8hpa dmso treatment SRP654941 17.18
SRR36435280 Regenerating head · dmso treatment Regenerating head 8hpa dmso treatment SRP654941 16.13
SRR36435310 Regenerating head · dmso treatment Regenerating head 0hpa dmso treatment SRP654941 15.42
SRR36435305 Regenerating head · dmso treatment Regenerating head 1.5hpa dmso treatment SRP654941 15.15
SRR36435271 Regenerating head · dmso treatment Regenerating head 12hpa dmso treatment SRP654941 12.27
SRR36435312 Regenerating head · dmso treatment Regenerating head 0hpa dmso treatment SRP654941 10.40
SRR36435281 Regenerating head · 25uM U0126 treatment Regenerating head 0hpa 25uM U0126 treatment SRP654941 28.05
SRR36435275 Regenerating head · 25uM U0126 treatment Regenerating head 8hpa 25uM U0126 treatment SRP654941 24.18
SRR36435303 Regenerating head · 25uM U0126 treatment Regenerating head 0hpa 25uM U0126 treatment SRP654941 21.99
SRR36435282 Regenerating head · 25uM U0126 treatment Regenerating head 0hpa 25uM U0126 treatment SRP654941 20.84
SRR36435296 Regenerating head · 25uM U0126 treatment Regenerating head 1.5hpa 25uM U0126 treatment SRP654941 20.84
SRR36435294 Regenerating head · 25uM U0126 treatment Regenerating head 1.5hpa 25uM U0126 treatment SRP654941 20.41
SRR36435295 Regenerating head · 25uM U0126 treatment Regenerating head 1.5hpa 25uM U0126 treatment SRP654941 19.96
SRR36435299 Regenerating head · 25uM U0126 treatment Regenerating head 3hpa 25uM U0126 treatment SRP654941 18.30
SRR36435298 Regenerating head · 25uM U0126 treatment Regenerating head 3hpa 25uM U0126 treatment SRP654941 18.08
SRR36435302 Regenerating head · 25uM U0126 treatment Regenerating head 0hpa 25uM U0126 treatment SRP654941 17.77
SRR36435283 Regenerating head · 25uM U0126 treatment Regenerating head 0hpa 25uM U0126 treatment SRP654941 17.12
SRR36435276 Regenerating head · 25uM U0126 treatment Regenerating head 8hpa 25uM U0126 treatment SRP654941 15.45
SRR36435301 Regenerating head · 25uM U0126 treatment Regenerating head 0hpa 25uM U0126 treatment SRP654941 15.01
SRR36435274 Regenerating head · 25uM U0126 treatment Regenerating head 8hpa 25uM U0126 treatment SRP654941 13.64
SRR36435297 Regenerating head · 25uM U0126 treatment Regenerating head 3hpa 25uM U0126 treatment SRP654941 12.55
SRR36435300 Regenerating foot · dmso treatment Regenerating foot 3hpa dmso treatment SRP654941 25.97
SRR36435265 Regenerating foot · dmso treatment Regenerating foot 1.5hpa dmso treatment SRP654941 21.19
SRR36435322 Regenerating foot · dmso treatment Regenerating foot 0hpa dmso treatment SRP654941 20.98
SRR36435289 Regenerating foot · dmso treatment Regenerating foot 3hpa dmso treatment SRP654941 20.83
SRR36435278 Regenerating foot · dmso treatment Regenerating foot 3hpa dmso treatment SRP654941 19.95
SRR36435323 Regenerating foot · dmso treatment Regenerating foot 0hpa dmso treatment SRP654941 19.51
SRR36435266 Regenerating foot · dmso treatment Regenerating foot 1.5hpa dmso treatment SRP654941 19.15
SRR36435267 Regenerating foot · dmso treatment Regenerating foot 1.5hpa dmso treatment SRP654941 17.01
SRR36435311 Regenerating foot · dmso treatment Regenerating foot 0hpa dmso treatment SRP654941 14.03
SRR36435318 Regenerating foot · 25uM U0126 treatment Regenerating foot 3hpa 25uM U0126 treatment SRP654941 22.83
SRR36435319 Regenerating foot · 25uM U0126 treatment Regenerating foot 3hpa 25uM U0126 treatment SRP654941 21.89
SRR36435314 Regenerating foot · 25uM U0126 treatment Regenerating foot 1.5hpa 25uM U0126 treatment SRP654941 21.86
SRR36435321 Regenerating foot · 25uM U0126 treatment Regenerating foot 0hpa 25uM U0126 treatment SRP654941 20.64
SRR36435315 Regenerating foot · 25uM U0126 treatment Regenerating foot 1.5hpa 25uM U0126 treatment SRP654941 18.88
SRR36435320 Regenerating foot · 25uM U0126 treatment Regenerating foot 0hpa 25uM U0126 treatment SRP654941 18.65
SRR36435316 Regenerating foot · 25uM U0126 treatment Regenerating foot 1.5hpa 25uM U0126 treatment SRP654941 18.61
SRR36435317 Regenerating foot · 25uM U0126 treatment Regenerating foot 3hpa 25uM U0126 treatment SRP654941 17.44
SRR36435270 Regenerating head · u0126 treatment Regenerating head 12hpa u0126 treatment SRP654941 20.70
SRR36435268 Regenerating head · u0126 treatment Regenerating head 12hpa u0126 treatment SRP654941 18.39
SRR36435269 Regenerating head · u0126 treatment Regenerating head 12hpa u0126 treatment SRP654941 18.19
SRR36435288 Whole animal · 25uM U0126 treatment Whole animal 12h 25uM U0126 treatment SRP654941 23.77
SRR36435287 Whole animal · 25uM U0126 treatment Whole animal 12h 25uM U0126 treatment SRP654941 23.46
SRR36435290 Whole animal · 25uM U0126 treatment Whole animal 12h 25uM U0126 treatment SRP654941 22.86
SRR36435291 Whole animal · dmso treatment Whole animal 12h dmso treatment SRP654941 23.71
SRR36435293 Whole animal · dmso treatment Whole animal 12h dmso treatment SRP654941 22.69
SRR36435292 Whole animal · dmso treatment Whole animal 12h dmso treatment SRP654941 19.91
SRR36435264 Regenerating foot · u0126 treatment Regenerating foot 0hpa u0126 treatment SRP654941 20.71

Source: CnidoSite RNA-seq expression matrices (HVULG_TPM, StringTie quantification over 60 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.

Co-expression network

Genes whose expression across the transcriptome samples of Hydra vulgaris tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.

DirectionPartnersMost correlated partnerPCC
Positively correlated18XP_065661790.10.91155396061138
Negatively correlated4XP_065657281.1-0.825213047248086

Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.

Single-cell expression

Whether this gene can be visualised in the single-cell atlases of Hydra vulgaris, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.

DatasetTissue / stageCellsCell typesThis geneMarker of
HVULG_siebert_atlasWhole animals · Adult (whole animal)25,43842not in this dataset

A gene is in viewer when the dataset ships a per-cell expression vector for it; marker only means it is in the dataset’s ranked marker table but no vector was exported, so the atlas cannot draw it; not in this dataset means the dataset’s own gene-ID table does not list it, so no expression claim can be made for that dataset. unmapped is deliberately weaker still: the dataset has no gene-ID table on CnidoSite yet, so nothing is claimed in either direction. Where markers are listed, the numbers are log2 fold change and the percentage of cells of that type in which the gene was detected.

Epigenetic marks

Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.

Peak calls overlapping this gene

AssaySamplePeaksRegion
ChIP-seqH3K27ac_head1Intron 1
H3K27ac_regenerating_head_0hr1Intron 1
H3K27ac_regenerating_head_24hr1Intron 1
H3K27ac_regenerating_head_4hr1Intron 1
H3K27ac_regenerating_head_6hr1Intron 1
H3K4me2_head1Intron 1
H3K4me2_regenerating_head_0hr1Intron 1
H3K4me2_regenerating_head_24hr1Intron 1
H3K4me2_regenerating_head_4hr1Intron 1
H3K4me2_regenerating_head_6hr1Intron 1
H3K4me2_wholeAnimal2Promoter (<=1kb) 1 · Intron 1
H3K4me3_head1Intron 1
H3K4me3_regenerating_head_0hr1Intron 1
H3K4me3_regenerating_head_24hr1Intron 1
H3K4me3_regenerating_head_4hr1Intron 1

7 further sample(s) also have peaks at this gene; open the assay page below to see them all.

Browse the full epigenomic landscape of this species: ChIP-seq.

What you can do with this gene

Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.

AnalysisWhat it doesStatus
Primer designDesign PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed.template foundopen →
BLASTSearch this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start.template foundopen →
Expression heatmapDraw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it.readyopen →
Gene family / orthogroupLook this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue.open →
Gene set analysisStart a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it.open →
TOP