Genomic Location: Ap14:17343114...17360498
NR annotation: XP_020629613.1, histone-lysine N-methyltransferase, H3 lysine-79 specific-like isoform X3 [Orbicella faveolata]
Species Astrangia poculata · all data for this species · gene families
| CDS |
| evm.model.Ap14.1604 |
| Transcript |
| evm.model.Ap14.1604 |
| Protein |
| evm.model.Ap14.1604 |
| UniProt accession | Description |
|---|---|
| Q8TEK3 | Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Homo sapiens OX=9606 GN=DOT1L PE=1 SV=3 |
| Q8INR6 | Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Drosophila melanogaster OX=7227 GN=gpp PE=1 SV=2 |
| Q6AW06 | Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Caenorhabditis elegans OX=6239 GN=dot-1.1 PE=1 SV=2 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0005416 (this species only) |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF08123 all species → | DOT1 | Histone methylation protein DOT1 | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR025789 all species → | Domain | Histone-lysine N-methyltransferase DOT1 domain | Interproscan |
| IPR029063 all species → | Homologous_superfamily | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Interproscan |
| IPR030445 all species → | Family | Histone H3-K79 methyltransferase | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR21451 all species → | HISTONE H3 METHYLTRANSFERASE | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0031151 all species → | Molecular Function | histone H3K79 methyltransferase activity | Interproscan |
| GO:0000077 all species → | Biological Process | DNA damage checkpoint signaling | Interproscan |
| GO:0005634 all species → | Cellular Component | nucleus | Interproscan |
| GO:0006281 all species → | Biological Process | DNA repair | Interproscan |
| GO:0051726 all species → | Biological Process | regulation of cell cycle | Interproscan |
| GO:2000677 all species → | Biological Process | regulation of transcription regulatory region DNA binding | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K11427 | DOT1L, DOT1; [histone H3]-lysine79 N-trimethyltransferase | EC:2.1.1.360 | Chromosome and associated proteins | ko03036 | deepkoala |
Transcript abundance of evm.model.Ap14.1604 across 49 RNA-seq samples of Astrangia poculata. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole organism · cold control | 14 | 0 | 0.00 | 0.00 | |
| whole organism · heat control | 12 | 1 | 22.43 | 269.11 | |
| whole organism · cold challenge | 12 | 0 | 0.00 | 0.00 | |
| whole organism · heat challenge | 11 | 0 | 0.00 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (APOCU_TPM,
StringTie quantification over 49 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.