Gene detail

Detailed information of evm.model.Ap2.2495 in Astrangia poculata

Genomic Location: Ap2:26280015...26293022
NR annotation: XP_020629309.1, NAD-dependent protein deacetylase sirtuin-1-like [Orbicella faveolata]
Species Astrangia poculata · all data for this species · gene families

Gene Structure

More details in JBrowse

Sequence

CDS

evm.model.Ap2.2495

atggcggatcgtgaagagcttgaatttaccacaacgaagcgagcccgtttgtcgtcagagaattcttttgatcaaaacgatagctctttcggtgcttctgataagaatgaacctcaagatagttctatttcgcgtctcaacgaaactgaacagagtgctaatgccgaaagcttttcatccgaaacgacgtcacgtgaacaacatgtcggacaagttgggcacgaaagactagaaagtgaagactttccgacatgtttcagcgtcgaagacggcttggatgatctagatgaacaccattatcagccaatagcaggccctatgggttggattcaaagacagatgaatctggatattaaccctgaagacattcttgcctatatggtgccccatgctcagttgcctcctaacatagataaatcgactttatggaaaatcattgtggatatccttaccgatcctacgcctagaccgaagcttgaccatatcaactcccttgatgatgttgtagaacttctcagagggtcaaagaacattattgttttaacaggggctggggtatctgtatcttgtggaatccctgactttagatctcgtgatggcatctatgccaaactaagtgtcgagtatcctgatcttccagaccctcaagcaatgtttgacatctcatatttctatcagaatccacggccattctttaagtttgcaaaggaaatctatccaggacaattcaaaccatcccttggtcacagattcataaggcagttggaatcaaatggacaactactgaagaactactcccagaatattgacacactggaacagatcgcaggcataacaagagtcatacaatgccatggctcgttttctactgcctcatgtacaaactgcaagcaccaagttgattgtgaggccataagggaagatatttttcagcaggttataccactttgcccaaaatgcccacaagatggaagttgctttgccataatgaaacctgatatagtattctttggcgaaagtcttccatctgagttttatcacaacctagatgaagattccgaaaaggctgatcttctgatagtcattggctcatcactgaaagtcagaccagttgctttaattccaagtcatgtgccacccgagataccacaggtgctcatcaaccgagagccgctcagacacatgacatttgacgtcgagttgctgggtgactgtgatgttatcatctcagagctatgccagcggctgggtggggcatggaacagtttgttggatgatgttgagataccttgtgtgggcagaggtctttcaacacctgagaagttgaatatgactgcagaggagcatccaggagtggaaagtgaagtgtcaggaagacaggagaatgaacagacgcaacttattacaccaaatgctgaaagcagtacattacaagatatgaagcaagtaagtgaagaagctggtcgagtaagtccactttgtcctgaggaagggcacgtgactgtcggcgagagcagtgtgtgtacagagactagtgacgagtcgtgcagagaccagccacgagcttcagctagtggacaagaaaatgagtgtgacgatacatcatgccaagaagattcgccacgatttctctttatgcctccgagccgttacattttctacggcgccgaagtcatggactcgcccctcccttccccctccccctcaagaaacctaacaagctacttggacagtactagtgaggggagtgacagcgacagtgttggagaaatcgacgatcatgaagctgccggtgatcagcttgatggtatcattgaagaactgttgagacatgaaagaagtcttgacaacgctcatcaaactacaacgaacagtgggcaagcggtttctcacagcagtgaaagtgactgtaacagcgatgatggctttgacgagggcgatgtagataaaggctcagagatcagtaacagtgaggtcacaaaacaagcattgtctcttatcctaggaggcttaagcagctacacatgcgcaagcgaggagaacagccgattatctgctggttctgatgatccagtggctcggggctcgagtgacccttactcactgtcacacgctacagacacgctgttgactgatcgcccattcagtggagtcaccatggataaaacgccaacaatgccagatcatctcgagcctggagaacaagagcagatcaaagatacagggcaaggcaactctgagtgccttcagcacttggtaactgaagatgatgttgacagtgatgtgaatgctgctgttacttctgattctttgcatccgtga

Transcript

evm.model.Ap2.2495

ATGGCGGATCGTGAAGAGCTTGAATTTACCACAACGAAGCGAGCCCGTTTGTCGTCAGAGAATTCTTTTGATCAAAACGATAGCTCTTTCGGTGCTTCTGATAAGAATGAACCTCAAGATAGTTCTATTTCGCGTCTCAACGAAACTGAACAGAGTGCTAATGCCGAAAGCTTTTCATCCGAAACGACGTCACGTGAACAACATGTCGGACAAGTTGGGCACGAAAGACTAGAAAGTGAAGACTTTCCGACATGTTTCAGCGTCGAAGACGGCTTGGATGATCTAGATGAACACCATTATCAGCCAATAGCAGGCCCTATGGGTTGGATTCAAAGACAGATGAATCTGGATATTAACCCTGAAGACATTCTTGCCTATATGGTGCCCCATGCTCAGTTGCCTCCTAACATAGATAAATCGACTTTATGGAAAATCATTGTGGATATCCTTACCGATCCTACGCCTAGACCGAAGCTTGACCATATCAACTCCCTTGATGATGTTGTAGAACTTCTCAGAGGGTCAAAGAACATTATTGTTTTAACAGGGGCTGGGGTATCTGTATCTTGTGGAATCCCTGACTTTAGATCTCGTGATGGCATCTATGCCAAACTAAGTGTCGAGTATCCTGATCTTCCAGACCCTCAAGCAATGTTTGACATCTCATATTTCTATCAGAATCCACGGCCATTCTTTAAGTTTGCAAAGGAAATCTATCCAGGACAATTCAAACCATCCCTTGGTCACAGATTCATAAGGCAGTTGGAATCAAATGGACAACTACTGAAGAACTACTCCCAGAATATTGACACACTGGAACAGATCGCAGGCATAACAAGAGTCATACAATGCCATGGCTCGTTTTCTACTGCCTCATGTACAAACTGCAAGCACCAAGTTGATTGTGAGGCCATAAGGGAAGATATTTTTCAGCAGGTTATACCACTTTGCCCAAAATGCCCACAAGATGGAAGTTGCTTTGCCATAATGAAACCTGATATAGTATTCTTTGGCGAAAGTCTTCCATCTGAGTTTTATCACAACCTAGATGAAGATTCCGAAAAGGCTGATCTTCTGATAGTCATTGGCTCATCACTGAAAGTCAGACCAGTTGCTTTAATTCCAAGTCATGTGCCACCCGAGATACCACAGGTGCTCATCAACCGAGAGCCGCTCAGACACATGACATTTGACGTCGAGTTGCTGGGTGACTGTGATGTTATCATCTCAGAGCTATGCCAGCGGCTGGGTGGGGCATGGAACAGTTTGTTGGATGATGTTGAGATACCTTGTGTGGGCAGAGGTCTTTCAACACCTGAGAAGTTGAATATGACTGCAGAGGAGCATCCAGGAGTGGAAAGTGAAGTGTCAGGAAGACAGGAGAATGAACAGACGCAACTTATTACACCAAATGCTGAAAGCAGTACATTACAAGATATGAAGCAAGTAAGTGAAGAAGCTGGTCGAGTAAGTCCACTTTGTCCTGAGGAAGGGCACGTGACTGTCGGCGAGAGCAGTGTGTGTACAGAGACTAGTGACGAGTCGTGCAGAGACCAGCCACGAGCTTCAGCTAGTGGACAAGAAAATGAGTGTGACGATACATCATGCCAAGAAGATTCGCCACGATTTCTCTTTATGCCTCCGAGCCGTTACATTTTCTACGGCGCCGAAGTCATGGACTCGCCCCTCCCTTCCCCCTCCCCCTCAAGAAACCTAACAAGCTACTTGGACAGTACTAGTGAGGGGAGTGACAGCGACAGTGTTGGAGAAATCGACGATCATGAAGCTGCCGGTGATCAGCTTGATGGTATCATTGAAGAACTGTTGAGACATGAAAGAAGTCTTGACAACGCTCATCAAACTACAACGAACAGTGGGCAAGCGGTTTCTCACAGCAGTGAAAGTGACTGTAACAGCGATGATGGCTTTGACGAGGGCGATGTAGATAAAGGCTCAGAGATCAGTAACAGTGAGGTCACAAAACAAGCATTGTCTCTTATCCTAGGAGGCTTAAGCAGCTACACATGCGCAAGCGAGGAGAACAGCCGATTATCTGCTGGTTCTGATGATCCAGTGGCTCGGGGCTCGAGTGACCCTTACTCACTGTCACACGCTACAGACACGCTGTTGACTGATCGCCCATTCAGTGGAGTCACCATGGATAAAACGCCAACAATGCCAGATCATCTCGAGCCTGGAGAACAAGAGCAGATCAAAGATACAGGGCAAGGCAACTCTGAGTGCCTTCAGCACTTGGTAACTGAAGATGATGTTGACAGTGATGTGAATGCTGCTGTTACTTCTGATTCTTTGCATCCGTGA

Protein

UniProt (Swiss-Prot top hit)

UniProt accession	Description
Q96EB6	NAD-dependent protein deacetylase sirtuin-1 OS=Homo sapiens OX=9606 GN=SIRT1 PE=1 SV=2
Q923E4	NAD-dependent protein deacetylase sirtuin-1 OS=Mus musculus OX=10090 GN=Sirt1 PE=1 SV=2
A0A0G2JZ79	NAD-dependent protein deacetylase sirtuin-1 OS=Rattus norvegicus OX=10116 GN=Sirt1 PE=3 SV=2

Gene family

Family type	Membership / link
Orthogroup (gene family)	OG0005877 (this species only)

Pfam domain

Pfam accession	Pfam name	Description	Type	Source
PF02146 all species →	SIR2	Sir2 family	Family	Interproscan

InterPro

InterPro term	Type	Description	Source
IPR029035 all species →	Homologous_superfamily	DHS-like NAD/FAD-binding domain superfamily	Interproscan
IPR050134 all species →	Family	NAD-dependent sirtuin protein deacylases	Interproscan
IPR026590 all species →	Domain	Sirtuin family, catalytic core domain	Interproscan
IPR003000 all species →	Family	Sirtuin family	Interproscan
IPR026591 all species →	Homologous_superfamily	Sirtuin, catalytic core small domain superfamily	Interproscan

PANTHER

PANTHER term	Description	Source
PTHR11085 all species →	NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED	Interproscan

Gene Ontology

GO term	Category	Description	Source
GO:0002039 all species →	Molecular Function	p53 binding	Interproscan
GO:0003714 all species →	Molecular Function	transcription corepressor activity	Interproscan
GO:0005634 all species →	Cellular Component	nucleus	Interproscan
GO:0005637 all species →	Cellular Component	nuclear inner membrane	Interproscan
GO:0005654 all species →	Cellular Component	nucleoplasm	Interproscan
GO:0017136 all species →	Molecular Function	histone deacetylase activity, NAD-dependent	Interproscan
GO:0033553 all species →	Cellular Component	rDNA heterochromatin	Interproscan
GO:0045892 all species →	Biological Process	negative regulation of DNA-templated transcription	Interproscan
GO:0070403 all species →	Molecular Function	NAD+ binding	Interproscan
GO:0070932 all species →	Biological Process	obsolete histone H3 deacetylation	Interproscan

Search by domain instead of by gene. Any accession above (InterPro, Pfam, PANTHER, GO, KEGG) can be used as a query on the Functional Domain Search page, which searches all 148 annotated genomes at once.

KEGG pathway

KO	Enzyme	Enzyme ID	Pathway	Map ID	Source
K11411	SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1	EC:2.3.1.286	Mitochondrial biogenesis	ko03029	deepkoala

Searching by KO or pathway ID across all species is available on the KEGG Pathway page.

Expression pattern (RNA-seq)

Transcript abundance of evm.model.Ap2.2495 across 49 RNA-seq samples of Astrangia poculata. This gene has no row in the species' RNA-seq expression matrix, so every value below is shown as zero — the matrix simply does not cover this transcript. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.

49Samples

0TPM > 0

4Conditions

0.0Max TPM

0.0Mean TPM

By condition

Condition	Samples	TPM > 0	Mean TPM	Max TPM	Mean, relative to max
whole organism · cold control	14	0	0.00	0.00
whole organism · heat control	12	0	0.00	0.00
whole organism · cold challenge	12	0	0.00	0.00
whole organism · heat challenge	11	0	0.00	0.00

Per sample · hover a bar for the full sample record · show / hide the sample table

SRA run	Condition	Tissue	Developmental stage	Treatment	Study
SRR10674714	whole organism · cold control	whole organism	not recorded	cold control	SRP237293
SRR10674715	whole organism · cold control	whole organism	not recorded	cold control	SRP237293
SRR10674724	whole organism · cold control	whole organism	not recorded	cold control	SRP237293
SRR10674733	whole organism · cold control	whole organism	not recorded	cold control	SRP237293
SRR10674734	whole organism · cold control	whole organism	not recorded	cold control	SRP237293
SRR10674735	whole organism · cold control	whole organism	not recorded	cold control	SRP237293
SRR10674736	whole organism · cold control	whole organism	not recorded	cold control	SRP237293
SRR10674737	whole organism · cold control	whole organism	not recorded	cold control	SRP237293
SRR10674739	whole organism · cold control	whole organism	not recorded	cold control	SRP237293
SRR10674743	whole organism · cold control	whole organism	not recorded	cold control	SRP237293
SRR10674746	whole organism · cold control	whole organism	not recorded	cold control	SRP237293
SRR10674747	whole organism · cold control	whole organism	not recorded	cold control	SRP237293
SRR10674748	whole organism · cold control	whole organism	not recorded	cold control	SRP237293
SRR10674750	whole organism · cold control	whole organism	not recorded	cold control	SRP237293
SRR10674706	whole organism · heat control	whole organism	not recorded	heat control	SRP237293
SRR10674707	whole organism · heat control	whole organism	not recorded	heat control	SRP237293
SRR10674708	whole organism · heat control	whole organism	not recorded	heat control	SRP237293
SRR10674717	whole organism · heat control	whole organism	not recorded	heat control	SRP237293
SRR10674718	whole organism · heat control	whole organism	not recorded	heat control	SRP237293
SRR10674720	whole organism · heat control	whole organism	not recorded	heat control	SRP237293
SRR10674721	whole organism · heat control	whole organism	not recorded	heat control	SRP237293
SRR10674725	whole organism · heat control	whole organism	not recorded	heat control	SRP237293
SRR10674731	whole organism · heat control	whole organism	not recorded	heat control	SRP237293
SRR10674741	whole organism · heat control	whole organism	not recorded	heat control	SRP237293
SRR10674752	whole organism · heat control	whole organism	not recorded	heat control	SRP237293
SRR10674753	whole organism · heat control	whole organism	not recorded	heat control	SRP237293
SRR10674711	whole organism · cold challenge	whole organism	not recorded	cold challenge	SRP237293
SRR10674712	whole organism · cold challenge	whole organism	not recorded	cold challenge	SRP237293
SRR10674713	whole organism · cold challenge	whole organism	not recorded	cold challenge	SRP237293
SRR10674722	whole organism · cold challenge	whole organism	not recorded	cold challenge	SRP237293
SRR10674723	whole organism · cold challenge	whole organism	not recorded	cold challenge	SRP237293
SRR10674730	whole organism · cold challenge	whole organism	not recorded	cold challenge	SRP237293
SRR10674732	whole organism · cold challenge	whole organism	not recorded	cold challenge	SRP237293
SRR10674738	whole organism · cold challenge	whole organism	not recorded	cold challenge	SRP237293
SRR10674740	whole organism · cold challenge	whole organism	not recorded	cold challenge	SRP237293
SRR10674744	whole organism · cold challenge	whole organism	not recorded	cold challenge	SRP237293
SRR10674745	whole organism · cold challenge	whole organism	not recorded	cold challenge	SRP237293
SRR10674749	whole organism · cold challenge	whole organism	not recorded	cold challenge	SRP237293
SRR10674709	whole organism · heat challenge	whole organism	not recorded	heat challenge	SRP237293
SRR10674710	whole organism · heat challenge	whole organism	not recorded	heat challenge	SRP237293
SRR10674716	whole organism · heat challenge	whole organism	not recorded	heat challenge	SRP237293
SRR10674719	whole organism · heat challenge	whole organism	not recorded	heat challenge	SRP237293
SRR10674726	whole organism · heat challenge	whole organism	not recorded	heat challenge	SRP237293
SRR10674727	whole organism · heat challenge	whole organism	not recorded	heat challenge	SRP237293
SRR10674728	whole organism · heat challenge	whole organism	not recorded	heat challenge	SRP237293
SRR10674729	whole organism · heat challenge	whole organism	not recorded	heat challenge	SRP237293
SRR10674742	whole organism · heat challenge	whole organism	not recorded	heat challenge	SRP237293
SRR10674751	whole organism · heat challenge	whole organism	not recorded	heat challenge	SRP237293
SRR10674754	whole organism · heat challenge	whole organism	not recorded	heat challenge	SRP237293

Source: CnidoSite RNA-seq expression matrices (APOCU_TPM, StringTie quantification over 49 runs), joined to SRA sample metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped by the descriptor carried in the expression matrix itself.