Genomic Location: chr3:6706321...6726506
NR annotation: XP_034025007.1, isobutyryl-CoA dehydrogenase, mitochondrial [Thalassophryne amazonica]
Species Aurelia coerulea · all data for this species · gene families
| CDS |
| evm.model.ptg000006l.344 |
| Transcript |
| evm.model.ptg000006l.344 |
| Protein |
| evm.model.ptg000006l.344 |
| UniProt accession | Description |
|---|---|
| Q9D7B6 | Isobutyryl-CoA dehydrogenase, mitochondrial OS=Mus musculus OX=10090 GN=Acad8 PE=1 SV=2 |
| Q9UKU7 | Isobutyryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD8 PE=1 SV=1 |
| Q0NXR6 | Isobutyryl-CoA dehydrogenase, mitochondrial OS=Bos taurus OX=9913 GN=ACAD8 PE=2 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0000727 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF02770 all species → | Acyl-CoA_dh_M | Acyl-CoA dehydrogenase, middle domain | Domain | Interproscan |
| PF00441 all species → | Acyl-CoA_dh_1 | Acyl-CoA dehydrogenase, C-terminal domain | Domain | Interproscan |
| PF02771 all species → | Acyl-CoA_dh_N | Acyl-CoA dehydrogenase, N-terminal domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR009100 all species → | Homologous_superfamily | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily | Interproscan |
| IPR037069 all species → | Homologous_superfamily | Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily | Interproscan |
| IPR006091 all species → | Domain | Acyl-CoA oxidase/dehydrogenase, middle domain | Interproscan |
| IPR052547 all species → | Family | Mitochondrial Isobutyryl-CoA Dehydrogenase | Interproscan |
| IPR036250 all species → | Homologous_superfamily | Acyl-CoA dehydrogenase-like, C-terminal | Interproscan |
| IPR006089 all species → | Conserved_site | Acyl-CoA dehydrogenase, conserved site | Interproscan |
| IPR009075 all species → | Domain | Acyl-CoA dehydrogenase/oxidase, C-terminal | Interproscan |
| IPR046373 all species → | Homologous_superfamily | Acyl-CoA oxidase/dehydrogenase, middle domain superfamily | Interproscan |
| IPR013786 all species → | Domain | Acyl-CoA dehydrogenase/oxidase, N-terminal | Interproscan |
| IPR034178 all species → | Family | Isobutyryl-CoA dehydrogenase | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR43831 all species → | ISOBUTYRYL-COA DEHYDROGENASE | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0016627 all species → | Molecular Function | oxidoreductase activity, acting on the CH-CH group of donors | Interproscan |
| GO:0050660 all species → | Molecular Function | flavin adenine dinucleotide binding | Interproscan |
| GO:0005739 all species → | Cellular Component | mitochondrion | Interproscan |
| GO:0003995 all species → | Molecular Function | acyl-CoA dehydrogenase activity | Interproscan |
| GO:0006629 all species → | Biological Process | lipid metabolic process | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K11538 | ACAD8; isobutyryl-CoA dehydrogenase | EC:1.3.99.- | Valine, leucine and isoleucine degradation | ko00280 | deepkoala |
Transcript abundance of evm.model.ptg000006l.344 across 30 RNA-seq samples of Aurelia coerulea. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
Every sample in this dataset carries its own condition — the source metadata gives each run a distinct treatment label — so this table is effectively a sample list. The per-sample chart below is the informative view here.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole organism · T_A1ES | 1 | 1 | 1.53 | 1.53 | |
| whole organism · T_C3E | 1 | 1 | 9.72 | 9.72 | |
| whole organism · T_C2P | 1 | 1 | 0.86 | 0.86 | |
| whole organism · T_A2ES | 1 | 1 | 3.98 | 3.98 | |
| whole organism · T_A3ES | 1 | 1 | 2.47 | 2.47 | |
| whole organism · T_C1AS | 1 | 1 | 2.36 | 2.36 | |
| whole organism · T_C2AS | 1 | 1 | 4.22 | 4.22 | |
| whole organism · T_C3AS | 1 | 1 | 4.89 | 4.89 | |
| whole organism · T_A1AS | 1 | 1 | 6.89 | 6.89 | |
| whole organism · T_A2AS | 1 | 1 | 7.36 | 7.36 | |
| whole organism · T_A3AS | 1 | 1 | 9.17 | 9.17 | |
| whole organism · T_C1E | 1 | 1 | 7.36 | 7.36 | |
| whole organism · T_C2E | 1 | 1 | 6.58 | 6.58 | |
| whole organism · T_C3P | 1 | 1 | 1.83 | 1.83 | |
| whole organism · T_AE1 | 1 | 1 | 16.91 | 16.91 | |
| whole organism · T_C3ES | 1 | 1 | 3.33 | 3.33 | |
| whole organism · T_AE2 | 1 | 1 | 17.24 | 17.24 | |
| whole organism · T_AE3 | 1 | 1 | 15.15 | 15.15 | |
| whole organism · T_AES1 | 1 | 1 | 13.94 | 13.94 | |
| whole organism · T_AES2 | 1 | 1 | 9.50 | 9.50 | |
| whole organism · T_AES3 | 1 | 1 | 9.53 | 9.53 | |
| whole organism · T_AAS1 | 1 | 1 | 12.59 | 12.59 | |
| whole organism · T_AAS2 | 1 | 1 | 9.26 | 9.26 | |
| whole organism · T_AAS3 | 1 | 1 | 9.10 | 9.10 | |
| whole organism · T_A1P | 1 | 1 | 0.45 | 0.45 | |
| whole organism · T_A2P | 1 | 1 | 2.20 | 2.20 | |
| whole organism · T_A3P | 1 | 1 | 0.53 | 0.53 | |
| whole organism · T_C1ES | 1 | 1 | 2.06 | 2.06 | |
| whole organism · T_C2ES | 1 | 1 | 2.66 | 2.66 | |
| whole organism · T_C1P | 1 | 1 | 1.37 | 1.37 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR25982246 | whole organism · T_A1ES | whole organism | not recorded | T_A1ES | SRP459341 | 1.53 |
| SRR25982262 | whole organism · T_C3E | whole organism | not recorded | T_C3E | SRP459341 | 9.72 |
| SRR25982274 | whole organism · T_C2P | whole organism | not recorded | T_C2P | SRP459341 | 0.86 |
| SRR25982273 | whole organism · T_A2ES | whole organism | not recorded | T_A2ES | SRP459341 | 3.98 |
| SRR25982272 | whole organism · T_A3ES | whole organism | not recorded | T_A3ES | SRP459341 | 2.47 |
| SRR25982271 | whole organism · T_C1AS | whole organism | not recorded | T_C1AS | SRP459341 | 2.36 |
| SRR25982270 | whole organism · T_C2AS | whole organism | not recorded | T_C2AS | SRP459341 | 4.22 |
| SRR25982269 | whole organism · T_C3AS | whole organism | not recorded | T_C3AS | SRP459341 | 4.89 |
| SRR25982268 | whole organism · T_A1AS | whole organism | not recorded | T_A1AS | SRP459341 | 6.89 |
| SRR25982267 | whole organism · T_A2AS | whole organism | not recorded | T_A2AS | SRP459341 | 7.36 |
| SRR25982266 | whole organism · T_A3AS | whole organism | not recorded | T_A3AS | SRP459341 | 9.17 |
| SRR25982265 | whole organism · T_C1E | whole organism | not recorded | T_C1E | SRP459341 | 7.36 |
| SRR25982264 | whole organism · T_C2E | whole organism | not recorded | T_C2E | SRP459341 | 6.58 |
| SRR25982263 | whole organism · T_C3P | whole organism | not recorded | T_C3P | SRP459341 | 1.83 |
| SRR25982261 | whole organism · T_AE1 | whole organism | not recorded | T_AE1 | SRP459341 | 16.91 |
| SRR25982247 | whole organism · T_C3ES | whole organism | not recorded | T_C3ES | SRP459341 | 3.33 |
| SRR25982260 | whole organism · T_AE2 | whole organism | not recorded | T_AE2 | SRP459341 | 17.24 |
| SRR25982259 | whole organism · T_AE3 | whole organism | not recorded | T_AE3 | SRP459341 | 15.15 |
| SRR25982258 | whole organism · T_AES1 | whole organism | not recorded | T_AES1 | SRP459341 | 13.94 |
| SRR25982257 | whole organism · T_AES2 | whole organism | not recorded | T_AES2 | SRP459341 | 9.50 |
| SRR25982256 | whole organism · T_AES3 | whole organism | not recorded | T_AES3 | SRP459341 | 9.53 |
| SRR25982255 | whole organism · T_AAS1 | whole organism | not recorded | T_AAS1 | SRP459341 | 12.59 |
| SRR25982254 | whole organism · T_AAS2 | whole organism | not recorded | T_AAS2 | SRP459341 | 9.26 |
| SRR25982253 | whole organism · T_AAS3 | whole organism | not recorded | T_AAS3 | SRP459341 | 9.10 |
| SRR25982252 | whole organism · T_A1P | whole organism | not recorded | T_A1P | SRP459341 | 0.45 |
| SRR25982251 | whole organism · T_A2P | whole organism | not recorded | T_A2P | SRP459341 | 2.20 |
| SRR25982250 | whole organism · T_A3P | whole organism | not recorded | T_A3P | SRP459341 | 0.53 |
| SRR25982249 | whole organism · T_C1ES | whole organism | not recorded | T_C1ES | SRP459341 | 2.06 |
| SRR25982248 | whole organism · T_C2ES | whole organism | not recorded | T_C2ES | SRP459341 | 2.66 |
| SRR25982275 | whole organism · T_C1P | whole organism | not recorded | T_C1P | SRP459341 | 1.37 |
Source: CnidoSite RNA-seq expression matrices (ACOER_TPM,
StringTie quantification over 30 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Aurelia coerulea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 28 | evm.model.ptg000009l.50 | 0.98609754536968 |
| Negatively correlated | 5 | evm.model.ptg000020l.49 | -0.860207492224184 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Aurelia coerulea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
