Genomic Location: chr13:1392312...1450611
NR annotation: XP_047128407.1, cytochrome b-245 heavy chain isoform X1 [Hydra vulgaris]
Species Aurelia coerulea · all data for this species · gene families
| CDS |
| evm.model.ptg000009l.1083 |
| Transcript |
| evm.model.ptg000009l.1083 |
| Protein |
| evm.model.ptg000009l.1083 |
| UniProt accession | Description |
|---|---|
| P52649 | NADPH oxidase 2 OS=Sus scrofa OX=9823 GN=CYBB PE=2 SV=3 |
| Q61093 | NADPH oxidase 2 OS=Mus musculus OX=10090 GN=Cybb PE=1 SV=1 |
| P04839 | NADPH oxidase 2 OS=Homo sapiens OX=9606 GN=CYBB PE=1 SV=2 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0000999 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF13300 all species → | DUF4078 | Domain of unknown function (DUF4078) | Family | Interproscan |
| PF01794 all species → | Ferric_reduct | Ferric reductase like transmembrane component | Family | Interproscan |
| PF08022 all species → | FAD_binding_8 | FAD-binding domain | Domain | Interproscan |
| PF08030 all species → | NAD_binding_6 | Ferric reductase NAD binding domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR039261 all species → | Homologous_superfamily | Ferredoxin-NADP reductase (FNR), nucleotide-binding domain | Interproscan |
| IPR050369 all species → | Family | Respiratory burst oxidase/Ferric reductase | Interproscan |
| IPR025066 all species → | Family | Coiled-coil domain-containing protein 174-like | Interproscan |
| IPR017938 all species → | Homologous_superfamily | Riboflavin synthase-like beta-barrel | Interproscan |
| IPR013130 all species → | Domain | Ferric reductase transmembrane component-like domain | Interproscan |
| IPR013112 all species → | Domain | FAD-binding 8 | Interproscan |
| IPR000778 all species → | Family | Cytochrome b245, heavy chain | Interproscan |
| IPR013121 all species → | Domain | Ferric reductase, NAD binding domain | Interproscan |
| IPR017927 all species → | Domain | FAD-binding domain, ferredoxin reductase-type | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR11972 all species → | NADPH OXIDASE | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0005886 all species → | Cellular Component | plasma membrane | Interproscan |
| GO:0006952 all species → | Biological Process | defense response | Interproscan |
| GO:0016175 all species → | Molecular Function | superoxide-generating NAD(P)H oxidase activity | Interproscan |
| GO:0042554 all species → | Biological Process | superoxide anion generation | Interproscan |
| GO:0043020 all species → | Cellular Component | NADPH oxidase complex | Interproscan |
| GO:0016491 all species → | Molecular Function | oxidoreductase activity | Interproscan |
| GO:0016020 all species → | Cellular Component | membrane | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K21421 | NOX2, GP91, CYBB; NADPH oxidase 2 | EC:1.-.-.- | Membrane trafficking | ko04131 | deepkoala |
Transcript abundance of evm.model.ptg000009l.1083 across 30 RNA-seq samples of Aurelia coerulea. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
Every sample in this dataset carries its own condition — the source metadata gives each run a distinct treatment label — so this table is effectively a sample list. The per-sample chart below is the informative view here.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole organism · T_A1ES | 1 | 1 | 1.61 | 1.61 | |
| whole organism · T_C3E | 1 | 1 | 22.54 | 22.54 | |
| whole organism · T_C2P | 1 | 1 | 2.03 | 2.03 | |
| whole organism · T_A2ES | 1 | 1 | 1.90 | 1.90 | |
| whole organism · T_A3ES | 1 | 1 | 3.42 | 3.42 | |
| whole organism · T_C1AS | 1 | 1 | 5.25 | 5.25 | |
| whole organism · T_C2AS | 1 | 1 | 3.55 | 3.55 | |
| whole organism · T_C3AS | 1 | 1 | 2.23 | 2.23 | |
| whole organism · T_A1AS | 1 | 1 | 6.56 | 6.56 | |
| whole organism · T_A2AS | 1 | 1 | 5.22 | 5.22 | |
| whole organism · T_A3AS | 1 | 1 | 4.53 | 4.53 | |
| whole organism · T_C1E | 1 | 1 | 7.64 | 7.64 | |
| whole organism · T_C2E | 1 | 1 | 9.33 | 9.33 | |
| whole organism · T_C3P | 1 | 1 | 1.86 | 1.86 | |
| whole organism · T_AE1 | 1 | 1 | 45.36 | 45.36 | |
| whole organism · T_C3ES | 1 | 1 | 2.04 | 2.04 | |
| whole organism · T_AE2 | 1 | 1 | 40.54 | 40.54 | |
| whole organism · T_AE3 | 1 | 1 | 30.86 | 30.86 | |
| whole organism · T_AES1 | 1 | 1 | 5.25 | 5.25 | |
| whole organism · T_AES2 | 1 | 1 | 4.87 | 4.87 | |
| whole organism · T_AES3 | 1 | 1 | 6.03 | 6.03 | |
| whole organism · T_AAS1 | 1 | 1 | 10.08 | 10.08 | |
| whole organism · T_AAS2 | 1 | 1 | 12.61 | 12.61 | |
| whole organism · T_AAS3 | 1 | 1 | 8.37 | 8.37 | |
| whole organism · T_A1P | 1 | 1 | 2.18 | 2.18 | |
| whole organism · T_A2P | 1 | 1 | 1.92 | 1.92 | |
| whole organism · T_A3P | 1 | 1 | 2.30 | 2.30 | |
| whole organism · T_C1ES | 1 | 1 | 2.20 | 2.20 | |
| whole organism · T_C2ES | 1 | 1 | 2.58 | 2.58 | |
| whole organism · T_C1P | 1 | 1 | 1.48 | 1.48 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR25982246 | whole organism · T_A1ES | whole organism | not recorded | T_A1ES | SRP459341 | 1.61 |
| SRR25982262 | whole organism · T_C3E | whole organism | not recorded | T_C3E | SRP459341 | 22.54 |
| SRR25982274 | whole organism · T_C2P | whole organism | not recorded | T_C2P | SRP459341 | 2.03 |
| SRR25982273 | whole organism · T_A2ES | whole organism | not recorded | T_A2ES | SRP459341 | 1.90 |
| SRR25982272 | whole organism · T_A3ES | whole organism | not recorded | T_A3ES | SRP459341 | 3.42 |
| SRR25982271 | whole organism · T_C1AS | whole organism | not recorded | T_C1AS | SRP459341 | 5.25 |
| SRR25982270 | whole organism · T_C2AS | whole organism | not recorded | T_C2AS | SRP459341 | 3.55 |
| SRR25982269 | whole organism · T_C3AS | whole organism | not recorded | T_C3AS | SRP459341 | 2.23 |
| SRR25982268 | whole organism · T_A1AS | whole organism | not recorded | T_A1AS | SRP459341 | 6.56 |
| SRR25982267 | whole organism · T_A2AS | whole organism | not recorded | T_A2AS | SRP459341 | 5.22 |
| SRR25982266 | whole organism · T_A3AS | whole organism | not recorded | T_A3AS | SRP459341 | 4.53 |
| SRR25982265 | whole organism · T_C1E | whole organism | not recorded | T_C1E | SRP459341 | 7.64 |
| SRR25982264 | whole organism · T_C2E | whole organism | not recorded | T_C2E | SRP459341 | 9.33 |
| SRR25982263 | whole organism · T_C3P | whole organism | not recorded | T_C3P | SRP459341 | 1.86 |
| SRR25982261 | whole organism · T_AE1 | whole organism | not recorded | T_AE1 | SRP459341 | 45.36 |
| SRR25982247 | whole organism · T_C3ES | whole organism | not recorded | T_C3ES | SRP459341 | 2.04 |
| SRR25982260 | whole organism · T_AE2 | whole organism | not recorded | T_AE2 | SRP459341 | 40.54 |
| SRR25982259 | whole organism · T_AE3 | whole organism | not recorded | T_AE3 | SRP459341 | 30.86 |
| SRR25982258 | whole organism · T_AES1 | whole organism | not recorded | T_AES1 | SRP459341 | 5.25 |
| SRR25982257 | whole organism · T_AES2 | whole organism | not recorded | T_AES2 | SRP459341 | 4.87 |
| SRR25982256 | whole organism · T_AES3 | whole organism | not recorded | T_AES3 | SRP459341 | 6.03 |
| SRR25982255 | whole organism · T_AAS1 | whole organism | not recorded | T_AAS1 | SRP459341 | 10.08 |
| SRR25982254 | whole organism · T_AAS2 | whole organism | not recorded | T_AAS2 | SRP459341 | 12.61 |
| SRR25982253 | whole organism · T_AAS3 | whole organism | not recorded | T_AAS3 | SRP459341 | 8.37 |
| SRR25982252 | whole organism · T_A1P | whole organism | not recorded | T_A1P | SRP459341 | 2.18 |
| SRR25982251 | whole organism · T_A2P | whole organism | not recorded | T_A2P | SRP459341 | 1.92 |
| SRR25982250 | whole organism · T_A3P | whole organism | not recorded | T_A3P | SRP459341 | 2.30 |
| SRR25982249 | whole organism · T_C1ES | whole organism | not recorded | T_C1ES | SRP459341 | 2.20 |
| SRR25982248 | whole organism · T_C2ES | whole organism | not recorded | T_C2ES | SRP459341 | 2.58 |
| SRR25982275 | whole organism · T_C1P | whole organism | not recorded | T_C1P | SRP459341 | 1.48 |
Source: CnidoSite RNA-seq expression matrices (ACOER_TPM,
StringTie quantification over 30 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Aurelia coerulea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 32 | evm.model.ptg000024l.843 | 0.987151038057734 |
| Negatively correlated | 3 | evm.model.ptg000018l.462 | -0.775806224045299 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Aurelia coerulea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
