Genomic Location: chr13:19248295...19250753
NR annotation: ABG21226.1, forkhead box-containing transcription factor FoxO [Clytia hemisphaerica]
Species Aurelia coerulea · all data for this species · gene families
| CDS |
| evm.model.ptg000009l.226 |
| Transcript |
| evm.model.ptg000009l.226 |
| Protein |
| evm.model.ptg000009l.226 |
| UniProt accession | Description |
|---|---|
| B4PTD3 | Forkhead box protein O OS=Drosophila yakuba OX=7245 GN=foxo PE=3 SV=2 |
| Q95V55 | Forkhead box protein O OS=Drosophila melanogaster OX=7227 GN=foxo PE=1 SV=1 |
| B3P0K6 | Forkhead box protein O OS=Drosophila erecta OX=7220 GN=foxo PE=3 SV=2 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0002173 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00250 all species → | Forkhead | Forkhead domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR030456 all species → | Conserved_site | Fork head domain conserved site 2 | Interproscan |
| IPR001766 all species → | Domain | Fork head domain | Interproscan |
| IPR036390 all species → | Homologous_superfamily | Winged helix DNA-binding domain superfamily | Interproscan |
| IPR036388 all species → | Homologous_superfamily | Winged helix-like DNA-binding domain superfamily | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR45767 all species → | FORKHEAD BOX PROTEIN O | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0003700 all species → | Molecular Function | DNA-binding transcription factor activity | Interproscan |
| GO:0006355 all species → | Biological Process | regulation of DNA-templated transcription | Interproscan |
| GO:0043565 all species → | Molecular Function | sequence-specific DNA binding | Interproscan |
| GO:0000978 all species → | Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | Interproscan |
| GO:0000981 all species → | Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | Interproscan |
| GO:0005634 all species → | Cellular Component | nucleus | Interproscan |
| GO:0006357 all species → | Biological Process | regulation of transcription by RNA polymerase II | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K09408 | FOXO3; forkhead box protein O3 | - | Transcription factors | ko03000 | deepkoala |
Transcript abundance of evm.model.ptg000009l.226 across 30 RNA-seq samples of Aurelia coerulea. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
Every sample in this dataset carries its own condition — the source metadata gives each run a distinct treatment label — so this table is effectively a sample list. The per-sample chart below is the informative view here.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole organism · T_A1ES | 1 | 1 | 1.43 | 1.43 | |
| whole organism · T_C3E | 1 | 1 | 37.07 | 37.07 | |
| whole organism · T_C2P | 1 | 1 | 1.94 | 1.94 | |
| whole organism · T_A2ES | 1 | 1 | 2.65 | 2.65 | |
| whole organism · T_A3ES | 1 | 1 | 3.98 | 3.98 | |
| whole organism · T_C1AS | 1 | 1 | 13.18 | 13.18 | |
| whole organism · T_C2AS | 1 | 1 | 12.64 | 12.64 | |
| whole organism · T_C3AS | 1 | 1 | 13.31 | 13.31 | |
| whole organism · T_A1AS | 1 | 1 | 11.25 | 11.25 | |
| whole organism · T_A2AS | 1 | 1 | 4.24 | 4.24 | |
| whole organism · T_A3AS | 1 | 1 | 10.23 | 10.23 | |
| whole organism · T_C1E | 1 | 1 | 21.79 | 21.79 | |
| whole organism · T_C2E | 1 | 1 | 26.16 | 26.16 | |
| whole organism · T_C3P | 1 | 1 | 2.17 | 2.17 | |
| whole organism · T_AE1 | 1 | 1 | 38.80 | 38.80 | |
| whole organism · T_C3ES | 1 | 1 | 4.58 | 4.58 | |
| whole organism · T_AE2 | 1 | 1 | 27.39 | 27.39 | |
| whole organism · T_AE3 | 1 | 1 | 25.16 | 25.16 | |
| whole organism · T_AES1 | 1 | 1 | 12.91 | 12.91 | |
| whole organism · T_AES2 | 1 | 1 | 22.91 | 22.91 | |
| whole organism · T_AES3 | 1 | 1 | 11.23 | 11.23 | |
| whole organism · T_AAS1 | 1 | 1 | 30.48 | 30.48 | |
| whole organism · T_AAS2 | 1 | 1 | 29.44 | 29.44 | |
| whole organism · T_AAS3 | 1 | 1 | 25.74 | 25.74 | |
| whole organism · T_A1P | 1 | 1 | 0.95 | 0.95 | |
| whole organism · T_A2P | 1 | 1 | 1.95 | 1.95 | |
| whole organism · T_A3P | 1 | 1 | 0.55 | 0.55 | |
| whole organism · T_C1ES | 1 | 1 | 2.00 | 2.00 | |
| whole organism · T_C2ES | 1 | 1 | 4.34 | 4.34 | |
| whole organism · T_C1P | 1 | 1 | 1.35 | 1.35 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR25982246 | whole organism · T_A1ES | whole organism | not recorded | T_A1ES | SRP459341 | 1.43 |
| SRR25982262 | whole organism · T_C3E | whole organism | not recorded | T_C3E | SRP459341 | 37.07 |
| SRR25982274 | whole organism · T_C2P | whole organism | not recorded | T_C2P | SRP459341 | 1.94 |
| SRR25982273 | whole organism · T_A2ES | whole organism | not recorded | T_A2ES | SRP459341 | 2.65 |
| SRR25982272 | whole organism · T_A3ES | whole organism | not recorded | T_A3ES | SRP459341 | 3.98 |
| SRR25982271 | whole organism · T_C1AS | whole organism | not recorded | T_C1AS | SRP459341 | 13.18 |
| SRR25982270 | whole organism · T_C2AS | whole organism | not recorded | T_C2AS | SRP459341 | 12.64 |
| SRR25982269 | whole organism · T_C3AS | whole organism | not recorded | T_C3AS | SRP459341 | 13.31 |
| SRR25982268 | whole organism · T_A1AS | whole organism | not recorded | T_A1AS | SRP459341 | 11.25 |
| SRR25982267 | whole organism · T_A2AS | whole organism | not recorded | T_A2AS | SRP459341 | 4.24 |
| SRR25982266 | whole organism · T_A3AS | whole organism | not recorded | T_A3AS | SRP459341 | 10.23 |
| SRR25982265 | whole organism · T_C1E | whole organism | not recorded | T_C1E | SRP459341 | 21.79 |
| SRR25982264 | whole organism · T_C2E | whole organism | not recorded | T_C2E | SRP459341 | 26.16 |
| SRR25982263 | whole organism · T_C3P | whole organism | not recorded | T_C3P | SRP459341 | 2.17 |
| SRR25982261 | whole organism · T_AE1 | whole organism | not recorded | T_AE1 | SRP459341 | 38.80 |
| SRR25982247 | whole organism · T_C3ES | whole organism | not recorded | T_C3ES | SRP459341 | 4.58 |
| SRR25982260 | whole organism · T_AE2 | whole organism | not recorded | T_AE2 | SRP459341 | 27.39 |
| SRR25982259 | whole organism · T_AE3 | whole organism | not recorded | T_AE3 | SRP459341 | 25.16 |
| SRR25982258 | whole organism · T_AES1 | whole organism | not recorded | T_AES1 | SRP459341 | 12.91 |
| SRR25982257 | whole organism · T_AES2 | whole organism | not recorded | T_AES2 | SRP459341 | 22.91 |
| SRR25982256 | whole organism · T_AES3 | whole organism | not recorded | T_AES3 | SRP459341 | 11.23 |
| SRR25982255 | whole organism · T_AAS1 | whole organism | not recorded | T_AAS1 | SRP459341 | 30.48 |
| SRR25982254 | whole organism · T_AAS2 | whole organism | not recorded | T_AAS2 | SRP459341 | 29.44 |
| SRR25982253 | whole organism · T_AAS3 | whole organism | not recorded | T_AAS3 | SRP459341 | 25.74 |
| SRR25982252 | whole organism · T_A1P | whole organism | not recorded | T_A1P | SRP459341 | 0.95 |
| SRR25982251 | whole organism · T_A2P | whole organism | not recorded | T_A2P | SRP459341 | 1.95 |
| SRR25982250 | whole organism · T_A3P | whole organism | not recorded | T_A3P | SRP459341 | 0.55 |
| SRR25982249 | whole organism · T_C1ES | whole organism | not recorded | T_C1ES | SRP459341 | 2.00 |
| SRR25982248 | whole organism · T_C2ES | whole organism | not recorded | T_C2ES | SRP459341 | 4.34 |
| SRR25982275 | whole organism · T_C1P | whole organism | not recorded | T_C1P | SRP459341 | 1.35 |
Source: CnidoSite RNA-seq expression matrices (ACOER_TPM,
StringTie quantification over 30 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Aurelia coerulea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 25 | evm.model.ptg000024l.829 | 0.963527865970239 |
| Negatively correlated | 15 | evm.model.ptg000032l.78 | -0.879981639248856 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Aurelia coerulea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
