Genomic Location: chr9:1747218...1784559
NR annotation: XP_047129000.1, zinc metalloproteinase-disintegrin-like MTP8 isoform X1 [Hydra vulgaris]
Species Aurelia coerulea · all data for this species · gene families
| CDS |
| evm.model.ptg000027l.114 |
| Transcript |
| evm.model.ptg000027l.114 |
| Protein |
| evm.model.ptg000027l.114 |
| UniProt accession | Description |
|---|---|
| Q61824 | Disintegrin and metalloproteinase domain-containing protein 12 OS=Mus musculus OX=10090 GN=Adam12 PE=1 SV=2 |
| O43184 | Disintegrin and metalloproteinase domain-containing protein 12 OS=Homo sapiens OX=9606 GN=ADAM12 PE=1 SV=3 |
| Q9H013 | Disintegrin and metalloproteinase domain-containing protein 19 OS=Homo sapiens OX=9606 GN=ADAM19 PE=1 SV=3 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0000819 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF01421 all species → | Reprolysin | Reprolysin (M12B) family zinc metalloprotease | Domain | Interproscan |
| PF00200 all species → | Disintegrin | Disintegrin | Domain | Interproscan |
| PF01562 all species → | Pep_M12B_propep | Reprolysin family propeptide | Family | Interproscan |
| PF08516 all species → | ADAM_CR | ADAM cysteine-rich | Family | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR001590 all species → | Domain | Peptidase M12B, ADAM/reprolysin | Interproscan |
| IPR001762 all species → | Domain | Disintegrin domain | Interproscan |
| IPR000742 all species → | Domain | EGF-like domain | Interproscan |
| IPR034027 all species → | Domain | Reprolysin domain, adamalysin-type | Interproscan |
| IPR036436 all species → | Homologous_superfamily | Disintegrin domain superfamily | Interproscan |
| IPR002870 all species → | Domain | Peptidase M12B, propeptide | Interproscan |
| IPR024079 all species → | Homologous_superfamily | Metallopeptidase, catalytic domain superfamily | Interproscan |
| IPR006586 all species → | Domain | ADAM, cysteine-rich domain | Interproscan |
| IPR018358 all species → | Conserved_site | Disintegrin, conserved site | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR11905 all species → | ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0004222 all species → | Molecular Function | metalloendopeptidase activity | Interproscan |
| GO:0006508 all species → | Biological Process | proteolysis | Interproscan |
| GO:0008237 all species → | Molecular Function | metallopeptidase activity | Interproscan |
| GO:0006509 all species → | Biological Process | membrane protein ectodomain proteolysis | Interproscan |
evm.model.ptg000027l.114.Transcript abundance of evm.model.ptg000027l.114 across 30 RNA-seq samples of Aurelia coerulea. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
Every sample in this dataset carries its own condition — the source metadata gives each run a distinct treatment label — so this table is effectively a sample list. The per-sample chart below is the informative view here.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole organism · T_A1ES | 1 | 1 | 0.95 | 0.95 | |
| whole organism · T_C3E | 1 | 1 | 9.73 | 9.73 | |
| whole organism · T_C2P | 1 | 1 | 0.81 | 0.81 | |
| whole organism · T_A2ES | 1 | 1 | 1.97 | 1.97 | |
| whole organism · T_A3ES | 1 | 1 | 2.09 | 2.09 | |
| whole organism · T_C1AS | 1 | 1 | 1.36 | 1.36 | |
| whole organism · T_C2AS | 1 | 1 | 1.73 | 1.73 | |
| whole organism · T_C3AS | 1 | 1 | 0.90 | 0.90 | |
| whole organism · T_A1AS | 1 | 1 | 5.65 | 5.65 | |
| whole organism · T_A2AS | 1 | 1 | 3.49 | 3.49 | |
| whole organism · T_A3AS | 1 | 1 | 3.46 | 3.46 | |
| whole organism · T_C1E | 1 | 1 | 5.15 | 5.15 | |
| whole organism · T_C2E | 1 | 1 | 7.44 | 7.44 | |
| whole organism · T_C3P | 1 | 1 | 0.77 | 0.77 | |
| whole organism · T_AE1 | 1 | 1 | 17.19 | 17.19 | |
| whole organism · T_C3ES | 1 | 1 | 0.54 | 0.54 | |
| whole organism · T_AE2 | 1 | 1 | 10.44 | 10.44 | |
| whole organism · T_AE3 | 1 | 1 | 14.08 | 14.08 | |
| whole organism · T_AES1 | 1 | 1 | 5.34 | 5.34 | |
| whole organism · T_AES2 | 1 | 1 | 10.21 | 10.21 | |
| whole organism · T_AES3 | 1 | 1 | 2.08 | 2.08 | |
| whole organism · T_AAS1 | 1 | 1 | 4.17 | 4.17 | |
| whole organism · T_AAS2 | 1 | 1 | 3.90 | 3.90 | |
| whole organism · T_AAS3 | 1 | 1 | 3.92 | 3.92 | |
| whole organism · T_A1P | 1 | 1 | 0.60 | 0.60 | |
| whole organism · T_A2P | 1 | 1 | 0.75 | 0.75 | |
| whole organism · T_A3P | 1 | 1 | 0.21 | 0.21 | |
| whole organism · T_C1ES | 1 | 1 | 1.40 | 1.40 | |
| whole organism · T_C2ES | 1 | 1 | 1.01 | 1.01 | |
| whole organism · T_C1P | 1 | 1 | 0.96 | 0.96 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR25982246 | whole organism · T_A1ES | whole organism | not recorded | T_A1ES | SRP459341 | 0.95 |
| SRR25982262 | whole organism · T_C3E | whole organism | not recorded | T_C3E | SRP459341 | 9.73 |
| SRR25982274 | whole organism · T_C2P | whole organism | not recorded | T_C2P | SRP459341 | 0.81 |
| SRR25982273 | whole organism · T_A2ES | whole organism | not recorded | T_A2ES | SRP459341 | 1.97 |
| SRR25982272 | whole organism · T_A3ES | whole organism | not recorded | T_A3ES | SRP459341 | 2.09 |
| SRR25982271 | whole organism · T_C1AS | whole organism | not recorded | T_C1AS | SRP459341 | 1.36 |
| SRR25982270 | whole organism · T_C2AS | whole organism | not recorded | T_C2AS | SRP459341 | 1.73 |
| SRR25982269 | whole organism · T_C3AS | whole organism | not recorded | T_C3AS | SRP459341 | 0.90 |
| SRR25982268 | whole organism · T_A1AS | whole organism | not recorded | T_A1AS | SRP459341 | 5.65 |
| SRR25982267 | whole organism · T_A2AS | whole organism | not recorded | T_A2AS | SRP459341 | 3.49 |
| SRR25982266 | whole organism · T_A3AS | whole organism | not recorded | T_A3AS | SRP459341 | 3.46 |
| SRR25982265 | whole organism · T_C1E | whole organism | not recorded | T_C1E | SRP459341 | 5.15 |
| SRR25982264 | whole organism · T_C2E | whole organism | not recorded | T_C2E | SRP459341 | 7.44 |
| SRR25982263 | whole organism · T_C3P | whole organism | not recorded | T_C3P | SRP459341 | 0.77 |
| SRR25982261 | whole organism · T_AE1 | whole organism | not recorded | T_AE1 | SRP459341 | 17.19 |
| SRR25982247 | whole organism · T_C3ES | whole organism | not recorded | T_C3ES | SRP459341 | 0.54 |
| SRR25982260 | whole organism · T_AE2 | whole organism | not recorded | T_AE2 | SRP459341 | 10.44 |
| SRR25982259 | whole organism · T_AE3 | whole organism | not recorded | T_AE3 | SRP459341 | 14.08 |
| SRR25982258 | whole organism · T_AES1 | whole organism | not recorded | T_AES1 | SRP459341 | 5.34 |
| SRR25982257 | whole organism · T_AES2 | whole organism | not recorded | T_AES2 | SRP459341 | 10.21 |
| SRR25982256 | whole organism · T_AES3 | whole organism | not recorded | T_AES3 | SRP459341 | 2.08 |
| SRR25982255 | whole organism · T_AAS1 | whole organism | not recorded | T_AAS1 | SRP459341 | 4.17 |
| SRR25982254 | whole organism · T_AAS2 | whole organism | not recorded | T_AAS2 | SRP459341 | 3.90 |
| SRR25982253 | whole organism · T_AAS3 | whole organism | not recorded | T_AAS3 | SRP459341 | 3.92 |
| SRR25982252 | whole organism · T_A1P | whole organism | not recorded | T_A1P | SRP459341 | 0.60 |
| SRR25982251 | whole organism · T_A2P | whole organism | not recorded | T_A2P | SRP459341 | 0.75 |
| SRR25982250 | whole organism · T_A3P | whole organism | not recorded | T_A3P | SRP459341 | 0.21 |
| SRR25982249 | whole organism · T_C1ES | whole organism | not recorded | T_C1ES | SRP459341 | 1.40 |
| SRR25982248 | whole organism · T_C2ES | whole organism | not recorded | T_C2ES | SRP459341 | 1.01 |
| SRR25982275 | whole organism · T_C1P | whole organism | not recorded | T_C1P | SRP459341 | 0.96 |
Source: CnidoSite RNA-seq expression matrices (ACOER_TPM,
StringTie quantification over 30 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Aurelia coerulea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 20 | evm.model.ptg000003l.1079 | 0.969963548761234 |
| Negatively correlated | 3 | evm.model.ptg000024l.627 | -0.799337305458147 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Aurelia coerulea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
