Genomic Location: chr21:15599767...15636048
NR annotation: AAV97963.1, protein-tyrosine kinase, partial [Hydractinia echinata]
Species Aurelia coerulea · all data for this species · gene families
| CDS |
| evm.model.ptg000028l.1022 |
| Transcript |
| evm.model.ptg000028l.1022 |
| Protein |
| evm.model.ptg000028l.1022 |
| UniProt accession | Description |
|---|---|
| Q00944 | Focal adhesion kinase 1 OS=Gallus gallus OX=9031 GN=PTK2 PE=1 SV=2 |
| Q91738 | Focal adhesion kinase 1 OS=Xenopus laevis OX=8355 GN=ptk2 PE=2 SV=2 |
| P34152 | Focal adhesion kinase 1 OS=Mus musculus OX=10090 GN=Ptk2 PE=1 SV=4 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0003173 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF07714 all species → | PK_Tyr_Ser-Thr | Protein tyrosine and serine/threonine kinase | Domain | Interproscan |
| PF00373 all species → | FERM_M | FERM central domain | Domain | Interproscan |
| PF18038 all species → | FERM_N_2 | FERM N-terminal domain | Domain | Interproscan |
| PF03623 all species → | Focal_AT | Focal adhesion targeting region | Domain | Interproscan |
| PF21477 all species → | FERM_C_FAK1 | FAK1/PYK2, FERM domain C-lobe | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR011993 all species → | Homologous_superfamily | PH-like domain superfamily | Interproscan |
| IPR008266 all species → | Active_site | Tyrosine-protein kinase, active site | Interproscan |
| IPR001245 all species → | Domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | Interproscan |
| IPR041784 all species → | Domain | FAK1/PYK2, FERM domain C-lobe | Interproscan |
| IPR019748 all species → | Domain | FERM central domain | Interproscan |
| IPR041390 all species → | Domain | Focal adhesion kinase, N-terminal | Interproscan |
| IPR011009 all species → | Homologous_superfamily | Protein kinase-like domain superfamily | Interproscan |
| IPR036137 all species → | Homologous_superfamily | Focal adhesion kinase, targeting (FAT) domain superfamily | Interproscan |
| IPR017441 all species → | Binding_site | Protein kinase, ATP binding site | Interproscan |
| IPR000299 all species → | Domain | FERM domain | Interproscan |
| IPR019749 all species → | Domain | Band 4.1 domain | Interproscan |
| IPR029071 all species → | Homologous_superfamily | Ubiquitin-like domain superfamily | Interproscan |
| IPR020635 all species → | Domain | Tyrosine-protein kinase, catalytic domain | Interproscan |
| IPR005189 all species → | Domain | Focal adhesion kinase, targeting (FAT) domain | Interproscan |
| IPR049385 all species → | Domain | FAK1-like, FERM domain C-lobe | Interproscan |
| IPR014352 all species → | Homologous_superfamily | FERM/acyl-CoA-binding protein superfamily | Interproscan |
| IPR000719 all species → | Domain | Protein kinase domain | Interproscan |
| IPR035963 all species → | Homologous_superfamily | FERM superfamily, second domain | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR46221 all species → | FERM AND PDZ DOMAIN-CONTAINING PROTEIN FAMILY MEMBER | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0004672 all species → | Molecular Function | protein kinase activity | Interproscan |
| GO:0006468 all species → | Biological Process | protein phosphorylation | Interproscan |
| GO:0004713 all species → | Molecular Function | protein tyrosine kinase activity | Interproscan |
| GO:0005925 all species → | Cellular Component | focal adhesion | Interproscan |
| GO:0007172 all species → | Biological Process | signal complex assembly | Interproscan |
| GO:0005524 all species → | Molecular Function | ATP binding | Interproscan |
| GO:0005856 all species → | Cellular Component | cytoskeleton | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K05725 | PTK2, FAK; focal adhesion kinase 1 | EC:2.7.10.2 | Protein phosphatases and associated proteins | ko01009 | deepkoala |
Transcript abundance of evm.model.ptg000028l.1022 across 30 RNA-seq samples of Aurelia coerulea. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
Every sample in this dataset carries its own condition — the source metadata gives each run a distinct treatment label — so this table is effectively a sample list. The per-sample chart below is the informative view here.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole organism · T_A1ES | 1 | 1 | 0.76 | 0.76 | |
| whole organism · T_C3E | 1 | 1 | 4.59 | 4.59 | |
| whole organism · T_C2P | 1 | 1 | 0.73 | 0.73 | |
| whole organism · T_A2ES | 1 | 1 | 0.80 | 0.80 | |
| whole organism · T_A3ES | 1 | 1 | 0.69 | 0.69 | |
| whole organism · T_C1AS | 1 | 1 | 1.73 | 1.73 | |
| whole organism · T_C2AS | 1 | 1 | 1.64 | 1.64 | |
| whole organism · T_C3AS | 1 | 1 | 1.41 | 1.41 | |
| whole organism · T_A1AS | 1 | 1 | 2.45 | 2.45 | |
| whole organism · T_A2AS | 1 | 1 | 1.62 | 1.62 | |
| whole organism · T_A3AS | 1 | 1 | 2.79 | 2.79 | |
| whole organism · T_C1E | 1 | 1 | 4.10 | 4.10 | |
| whole organism · T_C2E | 1 | 1 | 3.24 | 3.24 | |
| whole organism · T_C3P | 1 | 1 | 0.36 | 0.36 | |
| whole organism · T_AE1 | 1 | 1 | 7.94 | 7.94 | |
| whole organism · T_C3ES | 1 | 1 | 0.36 | 0.36 | |
| whole organism · T_AE2 | 1 | 1 | 5.31 | 5.31 | |
| whole organism · T_AE3 | 1 | 1 | 5.33 | 5.33 | |
| whole organism · T_AES1 | 1 | 1 | 5.36 | 5.36 | |
| whole organism · T_AES2 | 1 | 1 | 5.14 | 5.14 | |
| whole organism · T_AES3 | 1 | 1 | 2.59 | 2.59 | |
| whole organism · T_AAS1 | 1 | 1 | 4.14 | 4.14 | |
| whole organism · T_AAS2 | 1 | 1 | 2.91 | 2.91 | |
| whole organism · T_AAS3 | 1 | 1 | 4.05 | 4.05 | |
| whole organism · T_A1P | 1 | 1 | 0.30 | 0.30 | |
| whole organism · T_A2P | 1 | 1 | 0.33 | 0.33 | |
| whole organism · T_A3P | 1 | 1 | 0.25 | 0.25 | |
| whole organism · T_C1ES | 1 | 1 | 0.76 | 0.76 | |
| whole organism · T_C2ES | 1 | 1 | 0.53 | 0.53 | |
| whole organism · T_C1P | 1 | 1 | 0.29 | 0.29 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR25982246 | whole organism · T_A1ES | whole organism | not recorded | T_A1ES | SRP459341 | 0.76 |
| SRR25982262 | whole organism · T_C3E | whole organism | not recorded | T_C3E | SRP459341 | 4.59 |
| SRR25982274 | whole organism · T_C2P | whole organism | not recorded | T_C2P | SRP459341 | 0.73 |
| SRR25982273 | whole organism · T_A2ES | whole organism | not recorded | T_A2ES | SRP459341 | 0.80 |
| SRR25982272 | whole organism · T_A3ES | whole organism | not recorded | T_A3ES | SRP459341 | 0.69 |
| SRR25982271 | whole organism · T_C1AS | whole organism | not recorded | T_C1AS | SRP459341 | 1.73 |
| SRR25982270 | whole organism · T_C2AS | whole organism | not recorded | T_C2AS | SRP459341 | 1.64 |
| SRR25982269 | whole organism · T_C3AS | whole organism | not recorded | T_C3AS | SRP459341 | 1.41 |
| SRR25982268 | whole organism · T_A1AS | whole organism | not recorded | T_A1AS | SRP459341 | 2.45 |
| SRR25982267 | whole organism · T_A2AS | whole organism | not recorded | T_A2AS | SRP459341 | 1.62 |
| SRR25982266 | whole organism · T_A3AS | whole organism | not recorded | T_A3AS | SRP459341 | 2.79 |
| SRR25982265 | whole organism · T_C1E | whole organism | not recorded | T_C1E | SRP459341 | 4.10 |
| SRR25982264 | whole organism · T_C2E | whole organism | not recorded | T_C2E | SRP459341 | 3.24 |
| SRR25982263 | whole organism · T_C3P | whole organism | not recorded | T_C3P | SRP459341 | 0.36 |
| SRR25982261 | whole organism · T_AE1 | whole organism | not recorded | T_AE1 | SRP459341 | 7.94 |
| SRR25982247 | whole organism · T_C3ES | whole organism | not recorded | T_C3ES | SRP459341 | 0.36 |
| SRR25982260 | whole organism · T_AE2 | whole organism | not recorded | T_AE2 | SRP459341 | 5.31 |
| SRR25982259 | whole organism · T_AE3 | whole organism | not recorded | T_AE3 | SRP459341 | 5.33 |
| SRR25982258 | whole organism · T_AES1 | whole organism | not recorded | T_AES1 | SRP459341 | 5.36 |
| SRR25982257 | whole organism · T_AES2 | whole organism | not recorded | T_AES2 | SRP459341 | 5.14 |
| SRR25982256 | whole organism · T_AES3 | whole organism | not recorded | T_AES3 | SRP459341 | 2.59 |
| SRR25982255 | whole organism · T_AAS1 | whole organism | not recorded | T_AAS1 | SRP459341 | 4.14 |
| SRR25982254 | whole organism · T_AAS2 | whole organism | not recorded | T_AAS2 | SRP459341 | 2.91 |
| SRR25982253 | whole organism · T_AAS3 | whole organism | not recorded | T_AAS3 | SRP459341 | 4.05 |
| SRR25982252 | whole organism · T_A1P | whole organism | not recorded | T_A1P | SRP459341 | 0.30 |
| SRR25982251 | whole organism · T_A2P | whole organism | not recorded | T_A2P | SRP459341 | 0.33 |
| SRR25982250 | whole organism · T_A3P | whole organism | not recorded | T_A3P | SRP459341 | 0.25 |
| SRR25982249 | whole organism · T_C1ES | whole organism | not recorded | T_C1ES | SRP459341 | 0.76 |
| SRR25982248 | whole organism · T_C2ES | whole organism | not recorded | T_C2ES | SRP459341 | 0.53 |
| SRR25982275 | whole organism · T_C1P | whole organism | not recorded | T_C1P | SRP459341 | 0.29 |
Source: CnidoSite RNA-seq expression matrices (ACOER_TPM,
StringTie quantification over 30 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Aurelia coerulea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 34 | evm.model.ptg000004l.677 | 0.975647174307845 |
| Negatively correlated | 4 | evm.model.ptg000032l.78 | -0.870980913084262 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Aurelia coerulea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
