Genomic Location: chr21:16603442...16646091
NR annotation: NP_001267868.1, carbamoyl-phosphate synthetase/aspartate transcarbamoylase/dihydroorotase [Hydra vulgaris]
Species Aurelia coerulea · all data for this species · gene families
| CDS |
| evm.model.ptg000028l.1070 |
| Transcript |
| evm.model.ptg000028l.1070 |
| Protein |
| evm.model.ptg000028l.1070 |
| UniProt accession | Description |
|---|---|
| Q91437 | Multifunctional protein CAD OS=Squalus acanthias OX=7797 GN=CAD PE=2 SV=1 |
| P27708 | Multifunctional protein CAD OS=Homo sapiens OX=9606 GN=CAD PE=1 SV=3 |
| B2RQC6 | Multifunctional protein CAD OS=Mus musculus OX=10090 GN=Cad PE=1 SV=1 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0001105 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00988 all species → | CPSase_sm_chain | Carbamoyl-phosphate synthase small chain, CPSase domain | Domain | Interproscan |
| PF00117 all species → | GATase | Glutamine amidotransferase class-I | Domain | Interproscan |
| PF02787 all species → | CPSase_L_D3 | Carbamoyl-phosphate synthetase large chain, oligomerisation domain | Domain | Interproscan |
| PF00185 all species → | OTCace | Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain | Domain | Interproscan |
| PF02786 all species → | CPSase_L_D2 | Carbamoyl-phosphate synthase L chain, ATP binding domain | Domain | Interproscan |
| PF02729 all species → | OTCace_N | Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain | Domain | Interproscan |
| PF02142 all species → | MGS | MGS-like domain | Domain | Interproscan |
| PF01979 all species → | Amidohydro_1 | Amidohydrolase family | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR002474 all species → | Domain | Carbamoyl-phosphate synthase small subunit, N-terminal domain | Interproscan |
| IPR017926 all species → | Domain | Glutamine amidotransferase | Interproscan |
| IPR005479 all species → | Domain | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain | Interproscan |
| IPR029062 all species → | Homologous_superfamily | Class I glutamine amidotransferase-like | Interproscan |
| IPR005480 all species → | Domain | Carbamoyl-phosphate synthetase, large subunit oligomerisation domain | Interproscan |
| IPR006131 all species → | Domain | Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain | Interproscan |
| IPR011761 all species → | Domain | ATP-grasp fold | Interproscan |
| IPR011059 all species → | Homologous_superfamily | Metal-dependent hydrolase, composite domain superfamily | Interproscan |
| IPR036901 all species → | Homologous_superfamily | Aspartate/ornithine carbamoyltransferase superfamily | Interproscan |
| IPR002082 all species → | Family | Aspartate carbamoyltransferase | Interproscan |
| IPR006275 all species → | Family | Carbamoyl-phosphate synthase, large subunit | Interproscan |
| IPR006130 all species → | Family | Aspartate/ornithine carbamoyltransferase | Interproscan |
| IPR016185 all species → | Homologous_superfamily | Pre-ATP-grasp domain superfamily | Interproscan |
| IPR036480 all species → | Homologous_superfamily | Carbamoyl-phosphate synthase small subunit, N-terminal domain superfamily | Interproscan |
| IPR036914 all species → | Homologous_superfamily | Methylglyoxal synthase-like domain superfamily | Interproscan |
| IPR011607 all species → | Domain | Methylglyoxal synthase-like domain | Interproscan |
| IPR006132 all species → | Domain | Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding | Interproscan |
| IPR036897 all species → | Homologous_superfamily | Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily | Interproscan |
| IPR035686 all species → | Domain | Carbamoyl-phosphate synthase small subunit, GATase1 domain | Interproscan |
| IPR032466 all species → | Homologous_superfamily | Metal-dependent hydrolase | Interproscan |
| IPR002195 all species → | Conserved_site | Dihydroorotase, conserved site | Interproscan |
| IPR013815 all species → | Homologous_superfamily | ATP-grasp fold, subdomain 1 | Interproscan |
| IPR006274 all species → | Family | Carbamoyl-phosphate synthase, small subunit | Interproscan |
| IPR006680 all species → | Domain | Amidohydrolase-related | Interproscan |
| IPR005483 all species → | Domain | Carbamoyl-phosphate synthase large subunit, CPSase domain | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR11405 all species → | CARBAMOYLTRANSFERASE FAMILY MEMBER | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0004070 all species → | Molecular Function | aspartate carbamoyltransferase activity | Interproscan |
| GO:0004088 all species → | Molecular Function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | Interproscan |
| GO:0004151 all species → | Molecular Function | dihydroorotase activity | Interproscan |
| GO:0005737 all species → | Cellular Component | cytoplasm | Interproscan |
| GO:0005829 all species → | Cellular Component | cytosol | Interproscan |
| GO:0006207 all species → | Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | Interproscan |
| GO:0006228 all species → | Biological Process | UTP biosynthetic process | Interproscan |
| GO:0006541 all species → | Biological Process | glutamine metabolic process | Interproscan |
| GO:0006807 all species → | Biological Process | obsolete nitrogen compound metabolic process | Interproscan |
| GO:0019240 all species → | Biological Process | citrulline biosynthetic process | Interproscan |
| GO:0005524 all species → | Molecular Function | ATP binding | Interproscan |
| GO:0006520 all species → | Biological Process | amino acid metabolic process | Interproscan |
| GO:0016597 all species → | Molecular Function | amino acid binding | Interproscan |
| GO:0016743 all species → | Molecular Function | carboxyl- or carbamoyltransferase activity | Interproscan |
| GO:0046872 all species → | Molecular Function | metal ion binding | Interproscan |
| GO:0016810 all species → | Molecular Function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | Interproscan |
| GO:0016812 all species → | Molecular Function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides | Interproscan |
| GO:0016787 all species → | Molecular Function | hydrolase activity | Interproscan |
| KO | Enzyme | Enzyme ID | Pathway | Map ID | Source |
|---|---|---|---|---|---|
| K11540 | CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase | EC:6.3.5.5 EC:2.1.3.2 EC:3.5.2.3 | Peptidases and inhibitors | ko01002 | deepkoala |
Transcript abundance of evm.model.ptg000028l.1070 across 30 RNA-seq samples of Aurelia coerulea. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
Every sample in this dataset carries its own condition — the source metadata gives each run a distinct treatment label — so this table is effectively a sample list. The per-sample chart below is the informative view here.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole organism · T_A1ES | 1 | 1 | 4.12 | 4.12 | |
| whole organism · T_C3E | 1 | 1 | 3.58 | 3.58 | |
| whole organism · T_C2P | 1 | 1 | 2.02 | 2.02 | |
| whole organism · T_A2ES | 1 | 1 | 3.50 | 3.50 | |
| whole organism · T_A3ES | 1 | 1 | 3.44 | 3.44 | |
| whole organism · T_C1AS | 1 | 1 | 3.71 | 3.71 | |
| whole organism · T_C2AS | 1 | 1 | 4.37 | 4.37 | |
| whole organism · T_C3AS | 1 | 1 | 4.23 | 4.23 | |
| whole organism · T_A1AS | 1 | 1 | 11.68 | 11.68 | |
| whole organism · T_A2AS | 1 | 1 | 11.36 | 11.36 | |
| whole organism · T_A3AS | 1 | 1 | 16.15 | 16.15 | |
| whole organism · T_C1E | 1 | 1 | 3.75 | 3.75 | |
| whole organism · T_C2E | 1 | 1 | 3.36 | 3.36 | |
| whole organism · T_C3P | 1 | 1 | 1.92 | 1.92 | |
| whole organism · T_AE1 | 1 | 1 | 4.95 | 4.95 | |
| whole organism · T_C3ES | 1 | 1 | 6.61 | 6.61 | |
| whole organism · T_AE2 | 1 | 1 | 6.02 | 6.02 | |
| whole organism · T_AE3 | 1 | 1 | 5.86 | 5.86 | |
| whole organism · T_AES1 | 1 | 1 | 20.34 | 20.34 | |
| whole organism · T_AES2 | 1 | 1 | 22.34 | 22.34 | |
| whole organism · T_AES3 | 1 | 1 | 15.67 | 15.67 | |
| whole organism · T_AAS1 | 1 | 1 | 6.89 | 6.89 | |
| whole organism · T_AAS2 | 1 | 1 | 4.43 | 4.43 | |
| whole organism · T_AAS3 | 1 | 1 | 5.91 | 5.91 | |
| whole organism · T_A1P | 1 | 1 | 1.22 | 1.22 | |
| whole organism · T_A2P | 1 | 1 | 1.87 | 1.87 | |
| whole organism · T_A3P | 1 | 1 | 1.24 | 1.24 | |
| whole organism · T_C1ES | 1 | 1 | 5.33 | 5.33 | |
| whole organism · T_C2ES | 1 | 1 | 6.95 | 6.95 | |
| whole organism · T_C1P | 1 | 1 | 2.22 | 2.22 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR25982246 | whole organism · T_A1ES | whole organism | not recorded | T_A1ES | SRP459341 | 4.12 |
| SRR25982262 | whole organism · T_C3E | whole organism | not recorded | T_C3E | SRP459341 | 3.58 |
| SRR25982274 | whole organism · T_C2P | whole organism | not recorded | T_C2P | SRP459341 | 2.02 |
| SRR25982273 | whole organism · T_A2ES | whole organism | not recorded | T_A2ES | SRP459341 | 3.50 |
| SRR25982272 | whole organism · T_A3ES | whole organism | not recorded | T_A3ES | SRP459341 | 3.44 |
| SRR25982271 | whole organism · T_C1AS | whole organism | not recorded | T_C1AS | SRP459341 | 3.71 |
| SRR25982270 | whole organism · T_C2AS | whole organism | not recorded | T_C2AS | SRP459341 | 4.37 |
| SRR25982269 | whole organism · T_C3AS | whole organism | not recorded | T_C3AS | SRP459341 | 4.23 |
| SRR25982268 | whole organism · T_A1AS | whole organism | not recorded | T_A1AS | SRP459341 | 11.68 |
| SRR25982267 | whole organism · T_A2AS | whole organism | not recorded | T_A2AS | SRP459341 | 11.36 |
| SRR25982266 | whole organism · T_A3AS | whole organism | not recorded | T_A3AS | SRP459341 | 16.15 |
| SRR25982265 | whole organism · T_C1E | whole organism | not recorded | T_C1E | SRP459341 | 3.75 |
| SRR25982264 | whole organism · T_C2E | whole organism | not recorded | T_C2E | SRP459341 | 3.36 |
| SRR25982263 | whole organism · T_C3P | whole organism | not recorded | T_C3P | SRP459341 | 1.92 |
| SRR25982261 | whole organism · T_AE1 | whole organism | not recorded | T_AE1 | SRP459341 | 4.95 |
| SRR25982247 | whole organism · T_C3ES | whole organism | not recorded | T_C3ES | SRP459341 | 6.61 |
| SRR25982260 | whole organism · T_AE2 | whole organism | not recorded | T_AE2 | SRP459341 | 6.02 |
| SRR25982259 | whole organism · T_AE3 | whole organism | not recorded | T_AE3 | SRP459341 | 5.86 |
| SRR25982258 | whole organism · T_AES1 | whole organism | not recorded | T_AES1 | SRP459341 | 20.34 |
| SRR25982257 | whole organism · T_AES2 | whole organism | not recorded | T_AES2 | SRP459341 | 22.34 |
| SRR25982256 | whole organism · T_AES3 | whole organism | not recorded | T_AES3 | SRP459341 | 15.67 |
| SRR25982255 | whole organism · T_AAS1 | whole organism | not recorded | T_AAS1 | SRP459341 | 6.89 |
| SRR25982254 | whole organism · T_AAS2 | whole organism | not recorded | T_AAS2 | SRP459341 | 4.43 |
| SRR25982253 | whole organism · T_AAS3 | whole organism | not recorded | T_AAS3 | SRP459341 | 5.91 |
| SRR25982252 | whole organism · T_A1P | whole organism | not recorded | T_A1P | SRP459341 | 1.22 |
| SRR25982251 | whole organism · T_A2P | whole organism | not recorded | T_A2P | SRP459341 | 1.87 |
| SRR25982250 | whole organism · T_A3P | whole organism | not recorded | T_A3P | SRP459341 | 1.24 |
| SRR25982249 | whole organism · T_C1ES | whole organism | not recorded | T_C1ES | SRP459341 | 5.33 |
| SRR25982248 | whole organism · T_C2ES | whole organism | not recorded | T_C2ES | SRP459341 | 6.95 |
| SRR25982275 | whole organism · T_C1P | whole organism | not recorded | T_C1P | SRP459341 | 2.22 |
Source: CnidoSite RNA-seq expression matrices (ACOER_TPM,
StringTie quantification over 30 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Genes whose expression across the transcriptome samples of Aurelia coerulea tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 34 | evm.model.ptg000027l.168 | 0.975228309631103 |
| Negatively correlated | 4 | evm.model.ptg000006l.130 | -0.843947096509131 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Aurelia coerulea, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
No epigenomic data has been deposited for this species. The assays that exist across the site are described in the Epigenomic Data module.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |
