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This orthogroup contains 229 genes from 140 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 229 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR23007 | CBL | 185 / 229 | 80.8% | 98.9% of 187 | ≥80% support |
| GO | GO:0004842 Molecular Function | ubiquitin-protein transferase activity | 185 / 229 | 80.8% | 98.9% of 187 | ≥80% support |
| GO | GO:0061630 Molecular Function | ubiquitin protein ligase activity | 185 / 229 | 80.8% | 98.9% of 187 | ≥80% support |
| GO | GO:0045121 Cellular Component | membrane raft | 185 / 229 | 80.8% | 98.9% of 187 | ≥80% support |
| GO | GO:0023051 Biological Process | regulation of signaling | 185 / 229 | 80.8% | 98.9% of 187 | ≥80% support |
| GO | GO:0017124 Molecular Function | SH3 domain binding | 185 / 229 | 80.8% | 98.9% of 187 | ≥80% support |
| GO | GO:0007165 Biological Process | signal transduction | 185 / 229 | 80.8% | 98.9% of 187 | ≥80% support |
| GO | GO:0005886 Cellular Component | plasma membrane | 185 / 229 | 80.8% | 98.9% of 187 | ≥80% support |
| Pfam | PF02762 | Cbl_N3 — CBL proto-oncogene N-terminus, SH2-like domain | 175 / 229 | 76.4% | 93.6% of 187 | ≥50% support |
| Pfam | PF13920 | zf-C3HC4_3 — Zinc finger, C3HC4 type (RING finger) | 175 / 229 | 76.4% | 93.6% of 187 | ≥50% support |
| Pfam | PF02262 | Cbl_N — CBL proto-oncogene N-terminal domain 1 | 171 / 229 | 74.7% | 91.4% of 187 | ≥50% support |
| Pfam | PF02761 | Cbl_N2 — CBL proto-oncogene N-terminus, EF hand-like domain | 171 / 229 | 74.7% | 91.4% of 187 | ≥50% support |
| GO | GO:0001784 Molecular Function | phosphotyrosine residue binding | 180 / 229 | 78.6% | 96.3% of 187 | ≥50% support |
| GO | GO:0007166 Biological Process | cell surface receptor signaling pathway | 171 / 229 | 74.7% | 91.4% of 187 | ≥50% support |
| GO | GO:0005509 Molecular Function | calcium ion binding | 171 / 229 | 74.7% | 91.4% of 187 | ≥50% support |
| GO | GO:0007175 Biological Process | negative regulation of epidermal growth factor-activated receptor activity | 170 / 229 | 74.2% | 90.9% of 187 | ≥50% support |
| GO | GO:0030971 Molecular Function | receptor tyrosine kinase binding | 170 / 229 | 74.2% | 90.9% of 187 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Actinia equina | EGACTEQ4350008515-PA | XP_031566516.1 | E3 ubiquitin-protein ligase CBL-B-B-like isoform X3 [Actinia tenebrosa] | Q6NRE7 E3 ubiquitin-protein ligase CBL-B-B OS=Xenopus laevis OX=835 | JBrowse |
