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This orthogroup contains 272 genes from 143 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 272 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR22981 | 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED | 225 / 272 | 82.7% | 90.7% of 248 | ≥80% support |
| Pfam | PF03446 | NAD_binding_2 — NAD binding domain of 6-phosphogluconate dehydrogenase | 242 / 272 | 89.0% | 97.6% of 248 | ≥80% support |
| Pfam | PF14833 | NAD_binding_11 — NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase | 226 / 272 | 83.1% | 91.1% of 248 | ≥80% support |
| GO | GO:0050661 Molecular Function | NADP binding | 242 / 272 | 89.0% | 97.6% of 248 | ≥80% support |
| GO | GO:0051287 Molecular Function | NAD binding | 226 / 272 | 83.1% | 91.1% of 248 | ≥80% support |
| GO | GO:0016616 Molecular Function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 225 / 272 | 82.7% | 90.7% of 248 | ≥80% support |
| GO | GO:0016491 Molecular Function | oxidoreductase activity | 221 / 272 | 81.3% | 89.1% of 248 | ≥80% support |
| GO | GO:0008442 Molecular Function | 3-hydroxyisobutyrate dehydrogenase activity | 218 / 272 | 80.2% | 87.9% of 248 | ≥80% support |
| GO | GO:0005739 Cellular Component | mitochondrion | 206 / 272 | 75.7% | 83.1% of 248 | ≥50% support |
| GO | GO:0006574 Biological Process | valine catabolic process | 206 / 272 | 75.7% | 83.1% of 248 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Actinoscyphia liui | gene11900.t1 | XP_020917418.1 | 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Exaiptasia diaphana] | Q99L13 3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Mus mus | JBrowse |
