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This orthogroup contains 1,083 genes from 149 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 1,083 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR45702 | ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER | 897 / 1,083 | 82.8% | 99.7% of 900 | ≥80% support |
| GO | GO:0004222 Molecular Function | metalloendopeptidase activity | 898 / 1,083 | 82.9% | 99.5% of 903 | ≥80% support |
| GO | GO:0005886 Cellular Component | plasma membrane | 898 / 1,083 | 82.9% | 99.5% of 903 | ≥80% support |
| GO | GO:0006509 Biological Process | membrane protein ectodomain proteolysis | 897 / 1,083 | 82.8% | 99.3% of 903 | ≥80% support |
| GO | GO:0007219 Biological Process | Notch signaling pathway | 897 / 1,083 | 82.8% | 99.3% of 903 | ≥80% support |
| Pfam | PF13574 | Reprolysin_2 — Metallo-peptidase family M12B Reprolysin-like | 555 / 1,083 | 51.3% | 65.4% of 849 | ≥50% support |
| GO | GO:0008237 Molecular Function | metallopeptidase activity | 820 / 1,083 | 75.7% | 90.8% of 903 | ≥50% support |
| GO | GO:0006508 Biological Process | proteolysis | 743 / 1,083 | 68.6% | 82.3% of 903 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Acropora microphthalma | amic_s0006.g20.t1 | XP_029192520.2 | disintegrin and metalloproteinase domain-containing protein 10-like [Acropora millepora] | O77633 Disintegrin and metalloproteinase domain-containing protein | JBrowse |
| Acropora microphthalma | amic_s0053.g45.t1 | XP_015780892.1 | PREDICTED: ADAM 17-like protease [Acropora digitifera] | Q9VAC5 ADAM 17-like protease OS=Drosophila melanogaster OX=7227 GN= | JBrowse |
| Acropora microphthalma | amic_s0224.g8.t1 | XP_029182099.2 | disintegrin and metalloproteinase domain-containing protein 10-like [Acropora millepora] | O77633 Disintegrin and metalloproteinase domain-containing protein | JBrowse |
| Acropora microphthalma | amic_s0412.g6.t1 | XP_044183521.1 | disintegrin and metalloproteinase domain-containing protein 10-like [Acropora millepora] | O77633 Disintegrin and metalloproteinase domain-containing protein | JBrowse |
| Acropora microphthalma | amic_s0747.g1.t1 | XP_044180910.1 | LOW QUALITY PROTEIN: ADAM 17-like protease [Acropora millepora] | P78536 Disintegrin and metalloproteinase domain-containing protein | JBrowse |
| Acropora microphthalma | amic_s1414.g1.t1 | XP_044170403.1 | uncharacterized protein LOC122954426 [Acropora millepora] | – | JBrowse |
