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This orthogroup contains 378 genes from 144 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 378 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR14149 | RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF | 311 / 378 | 82.3% | 98.4% of 316 | ≥80% support |
| GO | GO:0005096 Molecular Function | GTPase activator activity | 312 / 378 | 82.5% | 97.8% of 319 | ≥80% support |
| GO | GO:0005938 Cellular Component | cell cortex | 311 / 378 | 82.3% | 97.5% of 319 | ≥80% support |
| GO | GO:0005516 Molecular Function | calmodulin binding | 310 / 378 | 82.0% | 97.2% of 319 | ≥80% support |
| GO | GO:0051015 Molecular Function | actin filament binding | 310 / 378 | 82.0% | 97.2% of 319 | ≥80% support |
| GO | GO:1903479 Biological Process | mitotic actomyosin contractile ring assembly actin filament organization | 310 / 378 | 82.0% | 97.2% of 319 | ≥80% support |
| Pfam | PF03836 | RasGAP_C — RasGAP C-terminus | 220 / 378 | 58.2% | 76.1% of 289 | ≥50% support |
| Pfam | PF00616 | RasGAP — GTPase-activator protein for Ras-like GTPase | 215 / 378 | 56.9% | 74.4% of 289 | ≥50% support |
| Pfam | PF00612 | IQ | 207 / 378 | 54.8% | 71.6% of 289 | ≥50% support |
| Pfam | PF00307 | CH | 199 / 378 | 52.7% | 68.9% of 289 | ≥50% support |
| GO | GO:0005515 Molecular Function | protein binding | 280 / 378 | 74.1% | 87.8% of 319 | ≥50% support |
| GO | GO:0043087 Biological Process | regulation of GTPase activity | 215 / 378 | 56.9% | 67.4% of 319 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Acropora microphthalma | amic_s0401.g2.t1 | XP_044183527.1 | ras GTPase-activating-like protein IQGAP1 [Acropora millepora] | P46940 Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens OX | JBrowse |
