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This orthogroup contains 252 genes from 136 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 252 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR42737 | GLUTATHIONE REDUCTASE | 220 / 252 | 87.3% | 98.7% of 223 | ≥80% support |
| Pfam | PF07992 | Pyr_redox_2 — Pyridine nucleotide-disulphide oxidoreductase | 216 / 252 | 85.7% | 96.9% of 223 | ≥80% support |
| GO | GO:0016491 Molecular Function | oxidoreductase activity | 223 / 252 | 88.5% | 100.0% of 223 | ≥80% support |
| GO | GO:0050660 Molecular Function | flavin adenine dinucleotide binding | 222 / 252 | 88.1% | 99.6% of 223 | ≥80% support |
| GO | GO:0004362 Molecular Function | glutathione-disulfide reductase (NADPH) activity | 220 / 252 | 87.3% | 98.7% of 223 | ≥80% support |
| GO | GO:0005829 Cellular Component | cytosol | 220 / 252 | 87.3% | 98.7% of 223 | ≥80% support |
| GO | GO:0006749 Biological Process | glutathione metabolic process | 220 / 252 | 87.3% | 98.7% of 223 | ≥80% support |
| GO | GO:0034599 Biological Process | cellular response to oxidative stress | 220 / 252 | 87.3% | 98.7% of 223 | ≥80% support |
| GO | GO:0045454 Biological Process | cell redox homeostasis | 220 / 252 | 87.3% | 98.7% of 223 | ≥80% support |
| GO | GO:0005739 Cellular Component | mitochondrion | 216 / 252 | 85.7% | 96.9% of 223 | ≥80% support |
| Pfam | PF02852 | Pyr_redox_dim — Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain | 194 / 252 | 77.0% | 87.0% of 223 | ≥50% support |
| GO | GO:0016668 Molecular Function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor | 157 / 252 | 62.3% | 70.4% of 223 | ≥50% support |
| GO | GO:0050661 Molecular Function | NADP binding | 152 / 252 | 60.3% | 68.2% of 223 | ≥50% support |
| KEGG | K00383 | GSR, gor — Diabetic cardiomyopathy | 177 / 252 | 70.2% | 97.3% of 182 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Acropora microphthalma | amic_s0066.g2.t1 | XP_044180611.1 | glutathione reductase, mitochondrial-like [Acropora millepora] | P47791 Glutathione reductase, mitochondrial OS=Mus musculus OX=1009 | JBrowse |
