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This orthogroup contains 221 genes from 143 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 221 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR10073 | DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL | 197 / 221 | 89.1% | 100.0% of 197 | ≥80% support |
| GO | GO:0006298 Biological Process | mismatch repair | 197 / 221 | 89.1% | 100.0% of 197 | ≥80% support |
| GO | GO:0016887 Molecular Function | ATP hydrolysis activity | 197 / 221 | 89.1% | 100.0% of 197 | ≥80% support |
| GO | GO:0032300 Cellular Component | mismatch repair complex | 197 / 221 | 89.1% | 100.0% of 197 | ≥80% support |
| GO | GO:0032389 Cellular Component | MutLalpha complex | 197 / 221 | 89.1% | 100.0% of 197 | ≥80% support |
| GO | GO:0140664 Molecular Function | ATP-dependent DNA damage sensor activity | 197 / 221 | 89.1% | 100.0% of 197 | ≥80% support |
| GO | GO:0005524 Molecular Function | ATP binding | 194 / 221 | 87.8% | 98.5% of 197 | ≥80% support |
| Pfam | PF08676 | MutL_C — MutL C terminal dimerisation domain | 173 / 221 | 78.3% | 89.2% of 194 | ≥50% support |
| Pfam | PF01119 | DNA_mis_repair — DNA mismatch repair protein, C-terminal domain | 169 / 221 | 76.5% | 87.1% of 194 | ≥50% support |
| Pfam | PF13589 | HATPase_c_3 — Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | 158 / 221 | 71.5% | 81.4% of 194 | ≥50% support |
| GO | GO:0030983 Molecular Function | mismatched DNA binding | 176 / 221 | 79.6% | 89.3% of 197 | ≥50% support |
| KEGG | K10858 | PMS2 — DNA repair and recombination proteins | 161 / 221 | 72.9% | 98.8% of 163 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Acropora microphthalma | amic_s0049.g6.t1 | XP_029199086.2 | LOW QUALITY PROTEIN: mismatch repair endonuclease PMS2-like [Acropora millepora] | P54278 Mismatch repair endonuclease PMS2 OS=Homo sapiens OX=9606 GN | JBrowse |
