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This orthogroup contains 320 genes from 141 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 320 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR46001 | TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG | 266 / 320 | 83.1% | 99.6% of 267 | ≥80% support |
| GO | GO:0005085 Molecular Function | guanyl-nucleotide exchange factor activity | 268 / 320 | 83.8% | 99.6% of 269 | ≥80% support |
| GO | GO:0007264 Biological Process | small GTPase-mediated signal transduction | 266 / 320 | 83.1% | 98.9% of 269 | ≥80% support |
| GO | GO:0016020 Cellular Component | membrane | 266 / 320 | 83.1% | 98.9% of 269 | ≥80% support |
| GO | GO:0045202 Cellular Component | synapse | 266 / 320 | 83.1% | 98.9% of 269 | ≥80% support |
| GO | GO:0050772 Biological Process | positive regulation of axonogenesis | 266 / 320 | 83.1% | 98.9% of 269 | ≥80% support |
| GO | GO:0090630 Biological Process | activation of GTPase activity | 266 / 320 | 83.1% | 98.9% of 269 | ≥80% support |
| Pfam | PF00621 | RhoGEF | 226 / 320 | 70.6% | 86.6% of 261 | ≥50% support |
| Pfam | PF18385 | Tiam_CC_Ex — T-lymphoma invasion and metastasis CC-Ex domain | 216 / 320 | 67.5% | 82.8% of 261 | ≥50% support |
| Pfam | PF00169 | PH | 193 / 320 | 60.3% | 74.0% of 261 | ≥50% support |
| Pfam | PF00595 | PDZ | 177 / 320 | 55.3% | 67.8% of 261 | ≥50% support |
| GO | GO:0005515 Molecular Function | protein binding | 205 / 320 | 64.1% | 76.2% of 269 | ≥50% support |
| GO | GO:0007165 Biological Process | signal transduction | 174 / 320 | 54.4% | 64.7% of 269 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Acropora pulchra | FUN_012379-T1 | XP_029197221.2 | protein still life, isoforms C/SIF type 2-like [Acropora millepora] | Q13009 Rho guanine nucleotide exchange factor TIAM1 OS=Homo sapiens | JBrowse |
