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This orthogroup contains 223 genes from 135 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 223 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR23103 | ALZHEIMER'S DISEASE BETA-AMYLOID RELATED | 200 / 223 | 89.7% | 99.5% of 201 | ≥80% support |
| Pfam | PF12925 | APP_E2 — E2 domain of amyloid precursor protein | 182 / 223 | 81.6% | 89.7% of 203 | ≥80% support |
| Pfam | PF02177 | APP_N — Amyloid A4 N-terminal heparin-binding | 180 / 223 | 80.7% | 88.7% of 203 | ≥80% support |
| Pfam | PF12924 | APP_Cu_bd — Copper-binding of amyloid precursor, CuBD | 179 / 223 | 80.3% | 88.2% of 203 | ≥80% support |
| GO | GO:0016020 Cellular Component | membrane | 200 / 223 | 89.7% | 99.0% of 202 | ≥80% support |
| GO | GO:0008201 Molecular Function | heparin binding | 180 / 223 | 80.7% | 89.1% of 202 | ≥80% support |
| GO | GO:0046914 Molecular Function | transition metal ion binding | 179 / 223 | 80.3% | 88.6% of 202 | ≥80% support |
| Pfam | PF10515 | APP_amyloid — Beta-amyloid precursor protein C-terminus | 178 / 223 | 79.8% | 87.7% of 203 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Acropora pulchra | FUN_041410-T1 | XP_015765072.1 | PREDICTED: amyloid-like protein 2, partial [Acropora digitifera] | Q06BR2 Amyloid-beta precursor-like protein OS=Doryteuthis pealeii O | JBrowse |
