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This orthogroup contains 938 genes from 138 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 938 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR10131 | TNF RECEPTOR ASSOCIATED FACTOR | 812 / 938 | 86.6% | 97.6% of 832 | ≥80% support |
| GO | GO:0033209 Biological Process | tumor necrosis factor-mediated signaling pathway | 799 / 938 | 85.2% | 92.8% of 861 | ≥80% support |
| GO | GO:0070534 Biological Process | protein K63-linked ubiquitination | 799 / 938 | 85.2% | 92.8% of 861 | ≥80% support |
| GO | GO:0061630 Molecular Function | ubiquitin protein ligase activity | 779 / 938 | 83.1% | 90.5% of 861 | ≥80% support |
| GO | GO:0031663 Biological Process | lipopolysaccharide-mediated signaling pathway | 774 / 938 | 82.5% | 89.9% of 861 | ≥80% support |
| GO | GO:0032813 Molecular Function | tumor necrosis factor receptor superfamily binding | 774 / 938 | 82.5% | 89.9% of 861 | ≥80% support |
| GO | GO:0045087 Biological Process | innate immune response | 774 / 938 | 82.5% | 89.9% of 861 | ≥80% support |
| GO | GO:0051092 Biological Process | positive regulation of NF-kappaB transcription factor activity | 774 / 938 | 82.5% | 89.9% of 861 | ≥80% support |
| Pfam | PF21355 | TRAF-mep_MATH — TRAF/meprin, MATH domain | 712 / 938 | 75.9% | 83.2% of 856 | ≥50% support |
| Pfam | PF02176 | zf-TRAF — TRAF-type zinc finger | 596 / 938 | 63.5% | 69.6% of 856 | ≥50% support |
| GO | GO:0005515 Molecular Function | protein binding | 727 / 938 | 77.5% | 84.4% of 861 | ≥50% support |
| GO | GO:0008270 Molecular Function | zinc ion binding | 617 / 938 | 65.8% | 71.7% of 861 | ≥50% support |
| GO | GO:0007165 Biological Process | signal transduction | 474 / 938 | 50.5% | 55.1% of 861 | ≥50% support |
| GO | GO:0042981 Biological Process | regulation of apoptotic process | 473 / 938 | 50.4% | 54.9% of 861 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Anthopleura xanthogrammica | ENSOJPP00000009818.1 | XP_031574150.1 | TNF receptor-associated factor 6-like [Actinia tenebrosa] | P70196 TNF receptor-associated factor 6 OS=Mus musculus OX=10090 GN | JBrowse |
