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This orthogroup contains 429 genes from 142 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 429 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR45754 | METHYLENETETRAHYDROFOLATE REDUCTASE | 390 / 429 | 90.9% | 100.0% of 390 | ≥80% support |
| Pfam | PF02219 | MTHFR — Methylenetetrahydrofolate reductase | 370 / 429 | 86.3% | 99.7% of 371 | ≥80% support |
| GO | GO:0004489 Molecular Function | methylenetetrahydrofolate reductase (NAD(P)H) activity | 390 / 429 | 90.9% | 100.0% of 390 | ≥80% support |
| GO | GO:0005829 Cellular Component | cytosol | 390 / 429 | 90.9% | 100.0% of 390 | ≥80% support |
| GO | GO:0009086 Biological Process | methionine biosynthetic process | 390 / 429 | 90.9% | 100.0% of 390 | ≥80% support |
| GO | GO:0035999 Biological Process | tetrahydrofolate interconversion | 390 / 429 | 90.9% | 100.0% of 390 | ≥80% support |
| GO | GO:0071949 Molecular Function | FAD binding | 390 / 429 | 90.9% | 100.0% of 390 | ≥80% support |
| GO | GO:0006555 Biological Process | methionine metabolic process | 370 / 429 | 86.3% | 94.9% of 390 | ≥80% support |
| KEGG | K25004 | MTHFR — Antifolate resistance | 318 / 429 | 74.1% | 97.6% of 326 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Catostylus mosaicus | ENSSJYP00000018783.1 | XP_033642011.1 | methylenetetrahydrofolate reductase-like [Asterias rubens] | P42898 Methylenetetrahydrofolate reductase (NADPH) OS=Homo sapiens | JBrowse |
| Catostylus mosaicus | ENSSJYP00000020230.1 | XP_022793225.1 | methylenetetrahydrofolate reductase-like [Stylophora pistillata] | Q5I598 Methylenetetrahydrofolate reductase (NADPH) OS=Bos taurus OX | JBrowse |
