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This orthogroup contains 401 genes from 143 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 401 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR46022 | PROTEIN PATCHED | 372 / 401 | 92.8% | 100.0% of 372 | ≥80% support |
| Pfam | PF02460 | Patched | 327 / 401 | 81.6% | 95.1% of 344 | ≥80% support |
| GO | GO:0005886 Cellular Component | plasma membrane | 372 / 401 | 92.8% | 100.0% of 372 | ≥80% support |
| GO | GO:0005119 Molecular Function | smoothened binding | 370 / 401 | 92.3% | 99.5% of 372 | ≥80% support |
| GO | GO:0008158 Molecular Function | hedgehog receptor activity | 370 / 401 | 92.3% | 99.5% of 372 | ≥80% support |
| GO | GO:0045879 Biological Process | negative regulation of smoothened signaling pathway | 370 / 401 | 92.3% | 99.5% of 372 | ≥80% support |
| GO | GO:0097108 Molecular Function | hedgehog family protein binding | 370 / 401 | 92.3% | 99.5% of 372 | ≥80% support |
| GO | GO:0016020 Cellular Component | membrane | 328 / 401 | 81.8% | 88.2% of 372 | ≥80% support |
| KEGG | K06225 | PTCH1 — Basal cell carcinoma | 261 / 401 | 65.1% | 99.6% of 262 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Catostylus mosaicus | ENSSJYP00000003347.1 | XP_006822692.1 | PREDICTED: protein patched homolog 1 [Saccoglossus kowalevskii] | Q98864 Protein patched homolog 1 OS=Danio rerio OX=7955 GN=ptch1 PE | JBrowse |
| Catostylus mosaicus | ENSSJYP00000003354.1 | XP_029189471.2 | protein patched homolog 1-like isoform X2 [Acropora millepora] | Q61115 Protein patched homolog 1 OS=Mus musculus OX=10090 GN=Ptch1 | JBrowse |
| Catostylus mosaicus | ENSSJYP00000003371.1 | EDO48180.1 | predicted protein, partial [Nematostella vectensis] | Q13635 Protein patched homolog 1 OS=Homo sapiens OX=9606 GN=PTCH1 P | JBrowse |
