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This orthogroup contains 268 genes from 142 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 268 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR11557 | PORPHOBILINOGEN DEAMINASE | 237 / 268 | 88.4% | 98.8% of 240 | ≥80% support |
| Pfam | PF01379 | Porphobil_deam — Porphobilinogen deaminase, dipyromethane cofactor binding domain | 235 / 268 | 87.7% | 97.5% of 241 | ≥80% support |
| GO | GO:0004418 Molecular Function | hydroxymethylbilane synthase activity | 239 / 268 | 89.2% | 99.2% of 241 | ≥80% support |
| GO | GO:0033014 Biological Process | tetrapyrrole biosynthetic process | 239 / 268 | 89.2% | 99.2% of 241 | ≥80% support |
| GO | GO:0005737 Cellular Component | cytoplasm | 237 / 268 | 88.4% | 98.3% of 241 | ≥80% support |
| GO | GO:0006783 Biological Process | heme biosynthetic process | 237 / 268 | 88.4% | 98.3% of 241 | ≥80% support |
| Pfam | PF03900 | Porphobil_deamC — Porphobilinogen deaminase, C-terminal domain | 199 / 268 | 74.3% | 82.6% of 241 | ≥50% support |
| GO | GO:0018160 Biological Process | peptidyl-pyrromethane cofactor linkage | 173 / 268 | 64.6% | 71.8% of 241 | ≥50% support |
| KEGG | K01749 | hemC, HMBS — Porphyrin metabolism | 192 / 268 | 71.6% | 99.5% of 193 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Catostylus mosaicus | ENSSJYP00000024195.1 | XP_047130126.1 | porphobilinogen deaminase [Hydra vulgaris] | P08397 Porphobilinogen deaminase OS=Homo sapiens OX=9606 GN=HMBS PE | JBrowse |
