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This orthogroup contains 225 genes from 137 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 225 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR11085 | NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED | 187 / 225 | 83.1% | 98.9% of 189 | ≥80% support |
| Pfam | PF02146 | SIR2 | 187 / 225 | 83.1% | 98.9% of 189 | ≥80% support |
| GO | GO:0005634 Cellular Component | nucleus | 189 / 225 | 84.0% | 100.0% of 189 | ≥80% support |
| GO | GO:0005654 Cellular Component | nucleoplasm | 188 / 225 | 83.6% | 99.5% of 189 | ≥80% support |
| GO | GO:0002039 Molecular Function | p53 binding | 187 / 225 | 83.1% | 98.9% of 189 | ≥80% support |
| GO | GO:0003714 Molecular Function | transcription corepressor activity | 187 / 225 | 83.1% | 98.9% of 189 | ≥80% support |
| GO | GO:0005637 Cellular Component | nuclear inner membrane | 187 / 225 | 83.1% | 98.9% of 189 | ≥80% support |
| GO | GO:0017136 Molecular Function | histone deacetylase activity, NAD-dependent | 187 / 225 | 83.1% | 98.9% of 189 | ≥80% support |
| GO | GO:0033553 Cellular Component | rDNA heterochromatin | 187 / 225 | 83.1% | 98.9% of 189 | ≥80% support |
| GO | GO:0045892 Biological Process | negative regulation of DNA-templated transcription | 187 / 225 | 83.1% | 98.9% of 189 | ≥80% support |
| GO | GO:0070403 Molecular Function | NAD+ binding | 187 / 225 | 83.1% | 98.9% of 189 | ≥80% support |
| GO | GO:0070932 Biological Process | obsolete histone H3 deacetylation | 187 / 225 | 83.1% | 98.9% of 189 | ≥80% support |
| KEGG | K11411 | SIRT1, SIR2L1 — Mitochondrial biogenesis | 154 / 225 | 68.4% | 98.1% of 157 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Catostylus mosaicus | ENSSJYP00000018350.1 | XP_047125773.1 | NAD-dependent protein deacetylase sirtuin-1 isoform X1 [Hydra vulgaris] | A0A0G2JZ79 NAD-dependent protein deacetylase sirtuin-1 OS=Rattus norveg | JBrowse |
| Catostylus mosaicus | ENSSJYP00000018358.1 | XP_033103130.1 | NAD-dependent protein deacetylase sirtuin-1-like [Anneissia japonica] | A0A0G2JZ79 NAD-dependent protein deacetylase sirtuin-1 OS=Rattus norveg | JBrowse |
