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This orthogroup contains 474 genes from 145 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 474 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR48099 | C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED | 306 / 474 | 64.6% | 96.2% of 318 | ≥50% support |
| Pfam | PF02882 | THF_DHG_CYH_C — Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain | 297 / 474 | 62.7% | 71.4% of 416 | ≥50% support |
| Pfam | PF00763 | THF_DHG_CYH — Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain | 277 / 474 | 58.4% | 66.6% of 416 | ≥50% support |
| Pfam | PF01268 | FTHFS — Formate--tetrahydrofolate ligase | 243 / 474 | 51.3% | 58.4% of 416 | ≥50% support |
| GO | GO:0004488 Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | 309 / 474 | 65.2% | 74.6% of 414 | ≥50% support |
| GO | GO:0005829 Cellular Component | cytosol | 308 / 474 | 65.0% | 74.4% of 414 | ≥50% support |
| GO | GO:0004477 Molecular Function | methenyltetrahydrofolate cyclohydrolase activity | 306 / 474 | 64.6% | 73.9% of 414 | ≥50% support |
| GO | GO:0035999 Biological Process | tetrahydrofolate interconversion | 306 / 474 | 64.6% | 73.9% of 414 | ≥50% support |
| GO | GO:0003824 Molecular Function | catalytic activity | 255 / 474 | 53.8% | 61.6% of 414 | ≥50% support |
| GO | GO:0005524 Molecular Function | ATP binding | 244 / 474 | 51.5% | 58.9% of 414 | ≥50% support |
| GO | GO:0004329 Molecular Function | formate-tetrahydrofolate ligase activity | 243 / 474 | 51.3% | 58.7% of 414 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Leptogorgia sarmentosa | ENSAPQP00000038784.1 | CAB3977525.1 | C-1-tetrahydrofolate synthase, cytoplasmic [Paramuricea clavata] | P11586 C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens O | JBrowse |
| Leptogorgia sarmentosa | ENSAPQP00000038802.1 | CAB3977525.1 | C-1-tetrahydrofolate synthase, cytoplasmic [Paramuricea clavata] | P11586 C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens O | JBrowse |
| Leptogorgia sarmentosa | ENSAPQP00000038819.1 | CAB3977525.1 | C-1-tetrahydrofolate synthase, cytoplasmic [Paramuricea clavata] | P11586 C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens O | JBrowse |
| Leptogorgia sarmentosa | ENSAPQP00000038829.1 | CAB3977525.1 | C-1-tetrahydrofolate synthase, cytoplasmic [Paramuricea clavata] | P11586 C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens O | JBrowse |
