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This orthogroup contains 309 genes from 143 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 309 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR43073 | DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)] | 277 / 309 | 89.6% | 98.2% of 282 | ≥80% support |
| GO | GO:0002058 Molecular Function | uracil binding | 271 / 309 | 87.7% | 95.8% of 283 | ≥80% support |
| GO | GO:0006210 Biological Process | thymine catabolic process | 271 / 309 | 87.7% | 95.8% of 283 | ≥80% support |
| GO | GO:0006212 Biological Process | uracil catabolic process | 271 / 309 | 87.7% | 95.8% of 283 | ≥80% support |
| GO | GO:0017113 Molecular Function | dihydropyrimidine dehydrogenase (NADP+) activity | 271 / 309 | 87.7% | 95.8% of 283 | ≥80% support |
| GO | GO:0050661 Molecular Function | NADP binding | 271 / 309 | 87.7% | 95.8% of 283 | ≥80% support |
| GO | GO:0005829 Cellular Component | cytosol | 270 / 309 | 87.4% | 95.4% of 283 | ≥80% support |
| Pfam | PF01180 | DHO_dh — Dihydroorotate dehydrogenase | 212 / 309 | 68.6% | 78.5% of 270 | ≥50% support |
| Pfam | PF14691 | Fer4_20 — Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster | 196 / 309 | 63.4% | 72.6% of 270 | ≥50% support |
| Pfam | PF14697 | Fer4_21 — 4Fe-4S dicluster domain | 196 / 309 | 63.4% | 72.6% of 270 | ≥50% support |
| Pfam | PF07992 | Pyr_redox_2 — Pyridine nucleotide-disulphide oxidoreductase | 184 / 309 | 59.6% | 68.2% of 270 | ≥50% support |
| GO | GO:0005737 Cellular Component | cytoplasm | 215 / 309 | 69.6% | 76.0% of 283 | ≥50% support |
| GO | GO:0016627 Molecular Function | oxidoreductase activity, acting on the CH-CH group of donors | 212 / 309 | 68.6% | 74.9% of 283 | ≥50% support |
| GO | GO:0051536 Molecular Function | iron-sulfur cluster binding | 210 / 309 | 68.0% | 74.2% of 283 | ≥50% support |
| GO | GO:0016491 Molecular Function | oxidoreductase activity | 184 / 309 | 59.6% | 65.0% of 283 | ≥50% support |
| KEGG | K00207 | DPYD — Drug metabolism - other enzymes | 184 / 309 | 59.6% | 86.0% of 214 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Leptogorgia sarmentosa | ENSAPQP00000020634.1 | CAB4009088.1 | dihydropyrimidine dehydrogenase [NADP(+)]-like, partial [Paramuricea clavata] | Q8CHR6 Dihydropyrimidine dehydrogenase [NADP(+)] OS=Mus musculus OX | JBrowse |
| Leptogorgia sarmentosa | ENSAPQP00000020644.1 | XP_028405372.1 | dihydropyrimidine dehydrogenase [NADP(+)]-like [Dendronephthya gigantea] | Q6NYG8 Dihydropyrimidine dehydrogenase [NADP(+)] OS=Danio rerio OX= | JBrowse |
| Leptogorgia sarmentosa | ENSAPQP00000020660.1 | XP_028405372.1 | dihydropyrimidine dehydrogenase [NADP(+)]-like [Dendronephthya gigantea] | Q12882 Dihydropyrimidine dehydrogenase [NADP(+)] OS=Homo sapiens OX | JBrowse |
