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This orthogroup contains 185 genes from 131 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 185 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR11009 | DER1-LIKE PROTEIN, DERLIN | 162 / 185 | 87.6% | 100.0% of 162 | ≥80% support |
| Pfam | PF04511 | DER1 | 163 / 185 | 88.1% | 100.0% of 163 | ≥80% support |
| GO | GO:0000839 Cellular Component | Hrd1p ubiquitin ligase ERAD-L complex | 162 / 185 | 87.6% | 100.0% of 162 | ≥80% support |
| GO | GO:0030176 Cellular Component | obsolete integral component of endoplasmic reticulum membrane | 162 / 185 | 87.6% | 100.0% of 162 | ≥80% support |
| GO | GO:0030433 Biological Process | obsolete ubiquitin-dependent ERAD pathway | 162 / 185 | 87.6% | 100.0% of 162 | ≥80% support |
| GO | GO:0030968 Biological Process | endoplasmic reticulum unfolded protein response | 162 / 185 | 87.6% | 100.0% of 162 | ≥80% support |
| GO | GO:0051787 Molecular Function | misfolded protein binding | 162 / 185 | 87.6% | 100.0% of 162 | ≥80% support |
| GO | GO:1990381 Molecular Function | ubiquitin-specific protease binding | 162 / 185 | 87.6% | 100.0% of 162 | ≥80% support |
| KEGG | K11519 | DERL1 — Pathways of neurodegeneration - multiple diseases | 140 / 185 | 75.7% | 100.0% of 140 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Leptogorgia sarmentosa | ENSAPQP00000005803.1 | XP_028392031.1 | derlin-1-like isoform X1 [Dendronephthya gigantea] | Q99J56 Derlin-1 OS=Mus musculus OX=10090 GN=Derl1 PE=1 SV=1 | JBrowse |
