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This orthogroup contains 924 genes from 108 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 924 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR13954 | IRE1-RELATED | 498 / 924 | 53.9% | 59.2% of 841 | ≥50% support |
| Pfam | PF00069 | Pkinase — Protein kinase domain | 728 / 924 | 78.8% | 86.7% of 840 | ≥50% support |
| Pfam | PF06479 | Ribonuc_2-5A — Ribonuclease 2-5A | 618 / 924 | 66.9% | 73.6% of 840 | ≥50% support |
| GO | GO:0004672 Molecular Function | protein kinase activity | 739 / 924 | 80.0% | 86.7% of 852 | ≥50% support |
| GO | GO:0005524 Molecular Function | ATP binding | 739 / 924 | 80.0% | 86.7% of 852 | ≥50% support |
| GO | GO:0006468 Biological Process | protein phosphorylation | 739 / 924 | 80.0% | 86.7% of 852 | ≥50% support |
| GO | GO:0005515 Molecular Function | protein binding | 648 / 924 | 70.1% | 76.1% of 852 | ≥50% support |
| GO | GO:0004540 Molecular Function | RNA nuclease activity | 623 / 924 | 67.4% | 73.1% of 852 | ≥50% support |
| GO | GO:0006397 Biological Process | mRNA processing | 621 / 924 | 67.2% | 72.9% of 852 | ≥50% support |
| GO | GO:0004674 Molecular Function | protein serine/threonine kinase activity | 507 / 924 | 54.9% | 59.5% of 852 | ≥50% support |
| GO | GO:0004521 Molecular Function | RNA endonuclease activity | 498 / 924 | 53.9% | 58.5% of 852 | ≥50% support |
| GO | GO:0030968 Biological Process | endoplasmic reticulum unfolded protein response | 498 / 924 | 53.9% | 58.5% of 852 | ≥50% support |
| GO | GO:0036498 Biological Process | IRE1-mediated unfolded protein response | 467 / 924 | 50.5% | 54.8% of 852 | ≥50% support |
| GO | GO:0051082 Molecular Function | unfolded protein binding | 467 / 924 | 50.5% | 54.8% of 852 | ≥50% support |
| GO | GO:0070059 Biological Process | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 467 / 924 | 50.5% | 54.8% of 852 | ≥50% support |
| GO | GO:1990604 Cellular Component | IRE1-TRAF2-ASK1 complex | 467 / 924 | 50.5% | 54.8% of 852 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Leptoseris scabra | ANN10375-RA | CAH3020795.1 | unnamed protein product [Porites evermanni] | P32361 Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Sac | JBrowse |
| Leptoseris scabra | ANN10376-RA | XP_020610850.1 | uncharacterized protein LOC110049396 [Orbicella faveolata] | O94537 Sensor for unfolded proteins in the ER ire1 OS=Schizosacchar | JBrowse |
