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This orthogroup contains 245 genes from 143 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 245 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR10290 | DNA TOPOISOMERASE I | 218 / 245 | 89.0% | 100.0% of 218 | ≥80% support |
| GO | GO:0003677 Molecular Function | DNA binding | 218 / 245 | 89.0% | 100.0% of 218 | ≥80% support |
| GO | GO:0003917 Molecular Function | DNA topoisomerase type I (single strand cut, ATP-independent) activity | 218 / 245 | 89.0% | 100.0% of 218 | ≥80% support |
| GO | GO:0005694 Cellular Component | chromosome | 218 / 245 | 89.0% | 100.0% of 218 | ≥80% support |
| GO | GO:0005730 Cellular Component | nucleolus | 218 / 245 | 89.0% | 100.0% of 218 | ≥80% support |
| GO | GO:0006260 Biological Process | DNA replication | 218 / 245 | 89.0% | 100.0% of 218 | ≥80% support |
| GO | GO:0006265 Biological Process | DNA topological change | 218 / 245 | 89.0% | 100.0% of 218 | ≥80% support |
| GO | GO:0007059 Biological Process | chromosome segregation | 218 / 245 | 89.0% | 100.0% of 218 | ≥80% support |
| Pfam | PF01028 | Topoisom_I — Eukaryotic DNA topoisomerase I, catalytic core | 195 / 245 | 79.6% | 89.5% of 218 | ≥50% support |
| Pfam | PF02919 | Topoisom_I_N — Eukaryotic DNA topoisomerase I, DNA binding fragment | 191 / 245 | 78.0% | 87.6% of 218 | ≥50% support |
| Pfam | PF14370 | Topo_C_assoc — C-terminal topoisomerase domain | 178 / 245 | 72.7% | 81.7% of 218 | ≥50% support |
| KEGG | K03163 | TOP1 — DNA replication proteins | 172 / 245 | 70.2% | 100.0% of 172 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Leptoseris scabra | ANN09260-RA | XP_029192757.2 | DNA topoisomerase I, mitochondrial-like [Acropora millepora] | Q7YR26 DNA topoisomerase 1 OS=Chlorocebus aethiops OX=9534 GN=TOP1 | JBrowse |
