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This orthogroup contains 395 genes from 136 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 395 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR46024 | HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS | 320 / 395 | 81.0% | 98.5% of 325 | ≥80% support |
| GO | GO:0005634 Cellular Component | nucleus | 324 / 395 | 82.0% | 99.7% of 325 | ≥80% support |
| GO | GO:0010629 Biological Process | negative regulation of gene expression | 320 / 395 | 81.0% | 98.5% of 325 | ≥80% support |
| GO | GO:0046974 Molecular Function | histone H3K9 methyltransferase activity | 320 / 395 | 81.0% | 98.5% of 325 | ≥80% support |
| GO | GO:0051567 Biological Process | obsolete histone H3-K9 methylation | 320 / 395 | 81.0% | 98.5% of 325 | ≥80% support |
| GO | GO:0070828 Biological Process | heterochromatin organization | 320 / 395 | 81.0% | 98.5% of 325 | ≥80% support |
| GO | GO:0090309 Biological Process | obsolete positive regulation of DNA methylation-dependent heterochromatin formation | 320 / 395 | 81.0% | 98.5% of 325 | ≥80% support |
| Pfam | PF18358 | Tudor_4 — Histone methyltransferase Tudor domain | 260 / 395 | 65.8% | 80.3% of 324 | ≥50% support |
| Pfam | PF00856 | SET | 246 / 395 | 62.3% | 75.9% of 324 | ≥50% support |
| Pfam | PF05033 | Pre-SET | 237 / 395 | 60.0% | 73.2% of 324 | ≥50% support |
| Pfam | PF01429 | MBD — Methyl-CpG binding domain | 234 / 395 | 59.2% | 72.2% of 324 | ≥50% support |
| Pfam | PF18359 | Tudor_5 — Histone methyltransferase Tudor domain 1 | 226 / 395 | 57.2% | 69.8% of 324 | ≥50% support |
| GO | GO:0005515 Molecular Function | protein binding | 246 / 395 | 62.3% | 75.7% of 325 | ≥50% support |
| GO | GO:0008270 Molecular Function | zinc ion binding | 244 / 395 | 61.8% | 75.1% of 325 | ≥50% support |
| GO | GO:0042054 Molecular Function | histone methyltransferase activity | 243 / 395 | 61.5% | 74.8% of 325 | ≥50% support |
| GO | GO:0003677 Molecular Function | DNA binding | 235 / 395 | 59.5% | 72.3% of 325 | ≥50% support |
| KEGG | K11421 | SETDB1 — Chromosome and associated proteins | 202 / 395 | 51.1% | 98.5% of 205 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Paramuricea clavata | CAB3979514.1 | CAB3979514.1 | histone-lysine N-methyltransferase SETDB1-like [Paramuricea clavata] | Q08BR4 Histone-lysine N-methyltransferase SETDB1-B OS=Danio rerio O | JBrowse |
| Paramuricea clavata | CAB3989631.1 | CAB3989631.1 | histone-lysine N-methyltransferase SETDB1-like [Paramuricea clavata] | Q6INA9 Histone-lysine N-methyltransferase SETDB1 OS=Xenopus laevis | JBrowse |
| Paramuricea clavata | CAB4004253.1 | CAB4004253.1 | histone-lysine N-methyltransferase SETDB1 isoform X2, partial [Paramuricea clavata] | Q6INA9 Histone-lysine N-methyltransferase SETDB1 OS=Xenopus laevis | JBrowse |
| Paramuricea clavata | CAB4004254.1 | CAB4004254.1 | histone-lysine N-methyltransferase SETDB1 isoform X2, partial [Paramuricea clavata] | Q6INA9 Histone-lysine N-methyltransferase SETDB1 OS=Xenopus laevis | JBrowse |
| Paramuricea clavata | CAB4004255.1 | CAB4004255.1 | histone-lysine N-methyltransferase SETDB1 isoform X3, partial [Paramuricea clavata] | Q6INA9 Histone-lysine N-methyltransferase SETDB1 OS=Xenopus laevis | JBrowse |
