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This orthogroup contains 319 genes from 144 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 319 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR45818 | PROTEIN VAV | 272 / 319 | 85.3% | 98.6% of 276 | ≥80% support |
| GO | GO:0005085 Molecular Function | guanyl-nucleotide exchange factor activity | 272 / 319 | 85.3% | 97.1% of 280 | ≥80% support |
| GO | GO:0005737 Cellular Component | cytoplasm | 272 / 319 | 85.3% | 97.1% of 280 | ≥80% support |
| GO | GO:0043087 Biological Process | regulation of GTPase activity | 272 / 319 | 85.3% | 97.1% of 280 | ≥80% support |
| GO | GO:0016477 Biological Process | cell migration | 267 / 319 | 83.7% | 95.4% of 280 | ≥80% support |
| GO | GO:0005515 Molecular Function | protein binding | 261 / 319 | 81.8% | 93.2% of 280 | ≥80% support |
| Pfam | PF00017 | SH2 | 218 / 319 | 68.3% | 79.0% of 276 | ≥50% support |
| Pfam | PF00621 | RhoGEF | 202 / 319 | 63.3% | 73.2% of 276 | ≥50% support |
| Pfam | PF00130 | C1_1 — Phorbol esters/diacylglycerol binding domain (C1 domain) | 188 / 319 | 58.9% | 68.1% of 276 | ≥50% support |
| Pfam | PF00307 | CH | 188 / 319 | 58.9% | 68.1% of 276 | ≥50% support |
| Pfam | PF00018 | SH3_1 — SH3 domain | 182 / 319 | 57.1% | 65.9% of 276 | ≥50% support |
| Pfam | PF00169 | PH | 164 / 319 | 51.4% | 59.4% of 276 | ≥50% support |
| KEGG | K05730 | VAV — Lipid and atherosclerosis | 172 / 319 | 53.9% | 98.3% of 175 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Paramuricea clavata | CAB3986231.1 | CAB3986231.1 | proto-oncogene vav-like [Paramuricea clavata] | P52735 Guanine nucleotide exchange factor VAV2 OS=Homo sapiens OX=9 | JBrowse |
| Paramuricea clavata | CAB3991798.1 | CAB3991798.1 | proto-oncogene vav-like, partial [Paramuricea clavata] | P52735 Guanine nucleotide exchange factor VAV2 OS=Homo sapiens OX=9 | JBrowse |
| Paramuricea clavata | CAB3991799.1 | CAB3991799.1 | proto-oncogene vav-like, partial [Paramuricea clavata] | P52735 Guanine nucleotide exchange factor VAV2 OS=Homo sapiens OX=9 | JBrowse |
