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This orthogroup contains 244 genes from 143 species. The functional annotation below is the consensus of the family's member genes — each term is reported with the number of member genes that carry it.
Support counts the member genes carrying the term. % of genes is that count over all 244 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR10073 | DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL | 209 / 244 | 85.7% | 99.1% of 211 | ≥80% support |
| GO | GO:0006298 Biological Process | mismatch repair | 211 / 244 | 86.5% | 100.0% of 211 | ≥80% support |
| GO | GO:0016887 Molecular Function | ATP hydrolysis activity | 209 / 244 | 85.7% | 99.1% of 211 | ≥80% support |
| GO | GO:0032300 Cellular Component | mismatch repair complex | 209 / 244 | 85.7% | 99.1% of 211 | ≥80% support |
| GO | GO:0140664 Molecular Function | ATP-dependent DNA damage sensor activity | 209 / 244 | 85.7% | 99.1% of 211 | ≥80% support |
| GO | GO:0005524 Molecular Function | ATP binding | 200 / 244 | 82.0% | 94.8% of 211 | ≥80% support |
| GO | GO:0030983 Molecular Function | mismatched DNA binding | 198 / 244 | 81.2% | 93.8% of 211 | ≥80% support |
| Pfam | PF01119 | DNA_mis_repair — DNA mismatch repair protein, C-terminal domain | 195 / 244 | 79.9% | 89.5% of 218 | ≥50% support |
| Pfam | PF13589 | HATPase_c_3 — Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | 181 / 244 | 74.2% | 83.0% of 218 | ≥50% support |
| Pfam | PF16413 | Mlh1_C — DNA mismatch repair protein Mlh1 C-terminus | 174 / 244 | 71.3% | 79.8% of 218 | ≥50% support |
| GO | GO:0032389 Cellular Component | MutLalpha complex | 181 / 244 | 74.2% | 85.8% of 211 | ≥50% support |
| KEGG | K08734 | MLH1 — DNA repair and recombination proteins | 160 / 244 | 65.6% | 87.0% of 184 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Paramuricea clavata | CAB3984481.1 | CAB3984481.1 | DNA mismatch repair Mlh1 isoform X1 [Paramuricea clavata] | P40692 DNA mismatch repair protein Mlh1 OS=Homo sapiens OX=9606 GN= | JBrowse |
| Paramuricea clavata | CAB3984482.1 | CAB3984482.1 | DNA mismatch repair Mlh1 isoform X1 [Paramuricea clavata] | P40692 DNA mismatch repair protein Mlh1 OS=Homo sapiens OX=9606 GN= | JBrowse |
