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Support counts the member genes carrying the term. % of genes is that count over all 474 members — the strict reading of “the whole family agrees”. % annotated is the same count over only those members for which this database has a prediction of that type, which shows how uniform the evidence is where evidence exists.
| Source | Term | Name / description | Support | % of genes | % annotated | Consistency |
|---|---|---|---|---|---|---|
| PANTHER | PTHR48099 | C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED | 306 / 474 | 64.6% | 96.2% of 318 | ≥50% support |
| Pfam | PF02882 | THF_DHG_CYH_C — Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain | 297 / 474 | 62.7% | 71.4% of 416 | ≥50% support |
| Pfam | PF00763 | THF_DHG_CYH — Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain | 277 / 474 | 58.4% | 66.6% of 416 | ≥50% support |
| Pfam | PF01268 | FTHFS — Formate--tetrahydrofolate ligase | 243 / 474 | 51.3% | 58.4% of 416 | ≥50% support |
| GO | GO:0004488 Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | 309 / 474 | 65.2% | 74.6% of 414 | ≥50% support |
| GO | GO:0005829 Cellular Component | cytosol | 308 / 474 | 65.0% | 74.4% of 414 | ≥50% support |
| GO | GO:0004477 Molecular Function | methenyltetrahydrofolate cyclohydrolase activity | 306 / 474 | 64.6% | 73.9% of 414 | ≥50% support |
| GO | GO:0035999 Biological Process | tetrahydrofolate interconversion | 306 / 474 | 64.6% | 73.9% of 414 | ≥50% support |
| GO | GO:0003824 Molecular Function | catalytic activity | 255 / 474 | 53.8% | 61.6% of 414 | ≥50% support |
| GO | GO:0005524 Molecular Function | ATP binding | 244 / 474 | 51.5% | 58.9% of 414 | ≥50% support |
| GO | GO:0004329 Molecular Function | formate-tetrahydrofolate ligase activity | 243 / 474 | 51.3% | 58.7% of 414 | ≥50% support |
Column guide: Top NCBI-NR hit and Top UniProt hit are the closest characterised sequences found by homology search — they are not identifiers of the CnidoSite gene itself. Where a species has no Swiss-Prot hit above threshold the UniProt column is shown as –. Click a gene ID for its full annotation page.
| Species | Gene ID | Top NCBI-NR hit (accession) |
Top NCBI-NR hit description (source organism) |
Top UniProt hit (Swiss-Prot) |
Genome browser |
|---|---|---|---|---|---|
| Hydra oligactis | HOLI00001.G49300 | WP_065761832.1 | MULTISPECIES: bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD [Pseudomonas] | Q1ICB3 Bifunctional protein FolD OS=Pseudomonas entomophila (strain | JBrowse |
| Hydra oligactis | HOLI00002.G19809 | MBI3521376.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD [Bacteroidota bacterium] | Q11UD1 Bifunctional protein FolD OS=Cytophaga hutchinsonii (strain | JBrowse |
| Hydra oligactis | HOLI00261.G43607 | XP_047137957.1 | C-1-tetrahydrofolate synthase, cytoplasmic-like [Hydra vulgaris] | Q922D8 C-1-tetrahydrofolate synthase, cytoplasmic OS=Mus musculus O | JBrowse |
| Hydra oligactis | HOLI00261.G43608 | XP_047137957.1 | C-1-tetrahydrofolate synthase, cytoplasmic-like [Hydra vulgaris] | Q6UB35 Monofunctional C1-tetrahydrofolate synthase, mitochondrial O | JBrowse |
| Hydra oligactis | HOLI00353.G42870 | WP_031571740.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD [Pararheinheimera texasensis] | Q3IF52 Bifunctional protein FolD OS=Pseudoalteromonas translucida ( | JBrowse |
| Hydra oligactis | HOLI00353.G43185 | WP_031567741.1 | inosine/guanosine kinase [Pararheinheimera texasensis] | P0AEW8 Guanosine-inosine kinase OS=Escherichia coli O157:H7 OX=8333 | JBrowse |
| Hydra oligactis | HOLI00655.G56782 | WP_105259500.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD [Rhodoferax sp. TS-BS-61-7] | Q12A51 Bifunctional protein FolD OS=Polaromonas sp. (strain JS666 / | JBrowse |
| Hydra oligactis | HOLI01142.G32518 | XP_012557792.1 | C-1-tetrahydrofolate synthase, cytoplasmic isoform X1 [Hydra vulgaris] | P27653 C-1-tetrahydrofolate synthase, cytoplasmic OS=Rattus norvegi | JBrowse |
| Hydra oligactis | HOLI01632.G57111 | WHL30282.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD [Pseudomonas juntendi] | A6UB98 Bifunctional protein FolD 2 OS=Sinorhizobium medicae (strain | JBrowse |
| Hydra oligactis | HOLI01799.G32036 | XP_047139218.1 | C-1-tetrahydrofolate synthase, cytoplasmic isoform X1 [Hydra vulgaris] | P27653 C-1-tetrahydrofolate synthase, cytoplasmic OS=Rattus norvegi | JBrowse |
| Hydra oligactis | HOLI02150.G23124 | WP_063459036.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD [Acidovorax sp. GW101-3H11] | A1TPZ6 Bifunctional protein FolD OS=Paracidovorax citrulli (strain | JBrowse |
| Hydra oligactis | HOLI03627.G26967 | XP_047137957.1 | C-1-tetrahydrofolate synthase, cytoplasmic-like [Hydra vulgaris] | P11586 C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens O | JBrowse |
| Hydra oligactis | HOLI12993.G24825 | XP_047137976.1 | C-1-tetrahydrofolate synthase, cytoplasmic isoform X2 [Hydra vulgaris] | P11586 C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens O | JBrowse |
| Hydra oligactis | HOLI15175.G31992 | XP_047137976.1 | C-1-tetrahydrofolate synthase, cytoplasmic isoform X2 [Hydra vulgaris] | P11586 C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens O | JBrowse |
