Genomic Location: LJWW01000023.1:107174...137776
NR annotation: KXJ27092.1, Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 [Exaiptasia diaphana]
Species Exaiptasia diaphana · all data for this species · gene families
| CDS |
| KXJ27092.1 |
| Protein |
| KXJ27092.1 |
| UniProt accession | Description |
|---|---|
| P0C6B8 | Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Rattus norvegicus OX=10116 GN=Svep1 PE=1 SV=1 |
| A2AVA0 | Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Mus musculus OX=10090 GN=Svep1 PE=1 SV=1 |
| Q4LDE5 | Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SVEP1 PE=1 SV=3 |
| Family type | Membership / link |
|---|---|
| Orthogroup (gene family) | OG0000607 (this species only) · gene tree & orthology |
| Pfam accession | Pfam name | Description | Type | Source |
|---|---|---|---|---|
| PF00092 all species → | VWA | von Willebrand factor type A domain | Domain | Interproscan |
| PF00008 all species → | EGF | EGF-like domain | Domain | Interproscan |
| PF14645 all species → | Chibby | Chibby family | Family | Interproscan |
| PF15711 all species → | ILEI | Interleukin-like EMT inducer | Domain | Interproscan |
| PF00754 all species → | F5_F8_type_C | F5/8 type C domain | Domain | Interproscan |
| PF00354 all species → | Pentaxin | Pentaxin family | Domain | Interproscan |
| PF00431 all species → | CUB | CUB domain | Domain | Interproscan |
| PF00084 all species → | Sushi | Sushi repeat (SCR repeat) | Domain | Interproscan |
| PF07699 all species → | Ephrin_rec_like | Tyrosine-protein kinase ephrin type A/B receptor-like | Domain | Interproscan |
| PF12662 all species → | cEGF | Complement Clr-like EGF-like | Domain | Interproscan |
| PF02494 all species → | HYR | HYR domain | Domain | Interproscan |
| InterPro term | Type | Description | Source |
|---|---|---|---|
| IPR035976 all species → | Homologous_superfamily | Sushi/SCR/CCP superfamily | Interproscan |
| IPR000742 all species → | Domain | EGF-like domain | Interproscan |
| IPR002035 all species → | Domain | von Willebrand factor, type A | Interproscan |
| IPR008979 all species → | Homologous_superfamily | Galactose-binding-like domain superfamily | Interproscan |
| IPR000436 all species → | Domain | Sushi/SCR/CCP domain | Interproscan |
| IPR000421 all species → | Domain | Coagulation factor 5/8 C-terminal domain | Interproscan |
| IPR000859 all species → | Domain | CUB domain | Interproscan |
| IPR028118 all species → | Family | Chibby family | Interproscan |
| IPR039477 all species → | Domain | ILEI/PANDER domain | Interproscan |
| IPR000152 all species → | PTM | EGF-type aspartate/asparagine hydroxylation site | Interproscan |
| IPR036465 all species → | Homologous_superfamily | von Willebrand factor A-like domain superfamily | Interproscan |
| IPR035914 all species → | Homologous_superfamily | Spermadhesin, CUB domain superfamily | Interproscan |
| IPR001759 all species → | Family | Pentraxin-related | Interproscan |
| IPR018097 all species → | Conserved_site | EGF-like calcium-binding, conserved site | Interproscan |
| IPR009030 all species → | Homologous_superfamily | Growth factor receptor cysteine-rich domain superfamily | Interproscan |
| IPR001881 all species → | Domain | EGF-like calcium-binding domain | Interproscan |
| IPR003609 all species → | Domain | PAN/Apple domain | Interproscan |
| IPR003410 all species → | Domain | HYR domain | Interproscan |
| IPR003006 all species → | Conserved_site | Immunoglobulin/major histocompatibility complex, conserved site | Interproscan |
| IPR006558 all species → | Domain | LamG-like jellyroll fold | Interproscan |
| IPR013320 all species → | Homologous_superfamily | Concanavalin A-like lectin/glucanase domain superfamily | Interproscan |
| IPR011641 all species → | Domain | Tyrosine-protein kinase ephrin type A/B receptor-like | Interproscan |
| IPR026823 all species → | Domain | Complement Clr-like EGF domain | Interproscan |
| IPR050350 all species → | Family | Complement & Cell Adhesion Regulators | Interproscan |
| PANTHER term | Description | Source |
|---|---|---|
| PTHR19325 all species → | COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING | Interproscan |
| GO term | Category | Description | Source |
|---|---|---|---|
| GO:0005509 all species → | Molecular Function | calcium ion binding | Interproscan |
KXJ27092.1.Transcript abundance of KXJ27092.1 across 72 RNA-seq samples of Exaiptasia diaphana. Values are TPM (transcripts per million) from the StringTie quantification; one bar is one sample, grouped and coloured by condition, sorted by expression within each group.
| Condition | Samples | TPM > 0 | Mean TPM | Max TPM | Mean, relative to max |
|---|---|---|---|---|---|
| whole animal · aposymbiotic | 36 | 32 | 5.92 | 11.83 | |
| whole animal · symbiotic | 36 | 35 | 16.02 | 42.24 |
| SRA run | Condition | Tissue | Developmental stage | Treatment | Study | TPM |
|---|---|---|---|---|---|---|
| SRR6202234 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 11.83 |
| SRR6202242 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 11.19 |
| SRR6202261 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 10.98 |
| SRR6202260 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 10.69 |
| SRR6202241 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 10.68 |
| SRR6202233 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 8.52 |
| SRR6202358 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 7.68 |
| SRR6202204 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 7.49 |
| SRR6202344 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 7.45 |
| SRR6202203 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 7.19 |
| SRR6202239 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 7.17 |
| SRR6202240 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 6.86 |
| SRR6202346 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 6.50 |
| SRR6202259 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 6.37 |
| SRR6202205 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 6.18 |
| SRR6202257 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 6.10 |
| SRR6202211 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 6.03 |
| SRR6202256 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 5.84 |
| SRR6202258 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 5.43 |
| SRR6202208 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 5.36 |
| SRR6202255 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 5.35 |
| SRR6202206 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 5.29 |
| SRR6202236 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 5.22 |
| SRR6202209 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 5.04 |
| SRR6202237 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 4.94 |
| SRR6202210 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 4.92 |
| SRR6202212 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 4.72 |
| SRR6202363 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 4.63 |
| SRR6202207 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 4.61 |
| SRR6202235 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 4.60 |
| SRR6202238 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 4.56 |
| SRR6202254 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 3.84 |
| SRR6202343 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 0.00 |
| SRR6202345 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 0.00 |
| SRR6202357 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 0.00 |
| SRR6202364 | whole animal · aposymbiotic | whole animal | not recorded | aposymbiotic | SRP120942 | 0.00 |
| SRR6202354 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 42.24 |
| SRR6202342 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 40.70 |
| SRR6202339 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 30.07 |
| SRR6202262 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 29.79 |
| SRR6202263 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 28.76 |
| SRR6202341 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 28.13 |
| SRR6202348 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 26.87 |
| SRR6202340 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 26.71 |
| SRR6202276 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 22.10 |
| SRR6202337 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 21.63 |
| SRR6202277 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 20.87 |
| SRR6202338 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 20.85 |
| SRR6202353 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 17.69 |
| SRR6202352 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 14.48 |
| SRR6202280 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 14.06 |
| SRR6202356 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 13.74 |
| SRR6202281 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 13.71 |
| SRR6202351 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 13.15 |
| SRR6202347 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 13.11 |
| SRR6202278 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 11.99 |
| SRR6202355 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 11.10 |
| SRR6202350 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 10.29 |
| SRR6202279 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 10.14 |
| SRR6202307 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 9.95 |
| SRR6202308 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 9.36 |
| SRR6202310 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 9.00 |
| SRR6202309 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 8.70 |
| SRR6202283 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 8.14 |
| SRR6202282 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 8.01 |
| SRR6202304 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 7.44 |
| SRR6202305 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 7.19 |
| SRR6202303 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 6.97 |
| SRR6202306 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 6.87 |
| SRR6202284 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 6.60 |
| SRR6202285 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 6.45 |
| SRR6202349 | whole animal · symbiotic | whole animal | not recorded | symbiotic | SRP120942 | 0.00 |
Source: CnidoSite RNA-seq expression matrices (EDIAP_TPM,
StringTie quantification over 72 runs), joined to SRA sample
metadata. Samples whose tissue/treatment is not recorded in the source metadata are grouped
by the descriptor carried in the expression matrix itself.
Peptides from this gene's protein product were identified in 2 re-processed proteomic datasets at a false discovery rate of q ≤ 0.01 (Comet + Percolator).
| Dataset | Species | Tissue / condition | Peptides | PSMs | Coverage | Best q | |
|---|---|---|---|---|---|---|---|
| PXD045587 | Exaiptasia diaphana | Symbiont Durusdinium trenchii Symbiosis establishment |
4 | 14 |
13%
|
0.000506757 | peptides |
|
K.MIAVALEQMIASSSLGNK.E q=0.000506757
K.LWADAYPSIEGLVQK.D q=0.000506757 K.ILEQEADISNMENR.N q=0.000851547 K.SYPDEFVTSPLSSGIR.E q=0.00101112 | |||||||
| PXD045585 | Exaiptasia diaphana | Symbiont Breviolum minutum Symbiosis establishment |
3 | 35 |
9.3%
|
0.000121477 | peptides |
|
K.LWADAYPSIEGLVQK.D q=0.000121477
K.ILEQEADISNMENR.N q=0.000121477 K.SYPDEFVTSPLSSGIR.E q=0.000231884 | |||||||
Search parameters for this evidence: Comet 2026.01,
precursor 10 ppm, fragment 0.5 Da,
fixed C+57.021464, variable M+15.9949,
PSM-level q ≤ 0.01 against
.
Parameters differ between datasets; open a dataset for its full provenance.
·
all proteins for Exaiptasia diaphana
Genes whose expression across the transcriptome samples of Exaiptasia diaphana tracks this one. Counts are over the whole network; the network view itself draws at most 100 partners per query gene (CNIDO_NET_TOP_K), so a hub gene can show fewer edges than the number below.
| Direction | Partners | Most correlated partner | PCC |
|---|---|---|---|
| Positively correlated | 36 | KXJ15396.1 | 0.932137273463615 |
| Negatively correlated | 7 | KXJ20980.1 | -0.654587267109676 |
Open this gene in Network Analysis → The network opens with the gene already entered and both directions selected. There you can add up to 9 more genes, switch between the positive and negative network, and export the edge list.
Whether this gene can be visualised in the single-cell atlases of Exaiptasia diaphana, and in which cell types it is a marker. Expression is stored per cell, so the violin plot and the cell-type means are computed in the viewer — open a dataset to see them.
No single-cell dataset has been published for this species. The atlases that do exist are listed in the Cell Atlas.
Chromatin and DNA-methylation data covering this gene. Peak calls are listed per sample with the genomic region the peak falls in; DNA methylation is listed as sample availability only, because those tables are queried by the DNA Methylation page itself.
| Assay | Sample | Peaks | Region |
|---|---|---|---|
| ATAC-seq | Mild_Stress_Aposym | 1 | Exon 1 |
Browse the full epigenomic landscape of this species: ChIP-seq · ATAC-seq.
| Sample | Methylation profile |
|---|---|
| whole_animal_aposymbiotic_1 | open |
| whole_animal_aposymbiotic_2 | open |
| whole_animal_aposymbiotic_3 | open |
| whole_animal_aposymbiotic_4 | open |
| whole_animal_aposymbiotic_5 | open |
| whole_animal_aposymbiotic_6 | open |
| whole_animal_aposymbiotic_7 | open |
| whole_animal_aposymbiotic_8 | open |
| whole_animal_aposymbiotic_9 | open |
| whole_animal_symbiotic_1 | open |
| whole_animal_symbiotic_10 | open |
| whole_animal_symbiotic_11 | open |
| whole_animal_symbiotic_12 | open |
| whole_animal_symbiotic_13 | open |
| whole_animal_symbiotic_14 | open |
| whole_animal_symbiotic_2 | open |
| whole_animal_symbiotic_3 | open |
| whole_animal_symbiotic_4 | open |
| whole_animal_symbiotic_5 | open |
| whole_animal_symbiotic_6 | open |
| whole_animal_symbiotic_7 | open |
| whole_animal_symbiotic_8 | open |
| whole_animal_symbiotic_9 | open |
The DNA Methylation page locates this gene by scanning the bisulphite table, which holds one row per cytosine. For the largest datasets that scan takes a while to return; it does not mean the link is broken.
Every tool below opens with this gene already entered, so you land on the analysis rather than on an empty form. Links open in a new tab.
| Analysis | What it does | Status | |
|---|---|---|---|
| Primer design | Design PCR / qPCR primers on this gene’s sequence with the published primer3 settings. Opens with the primers already computed. | template found | open → |
| BLAST | Search this gene’s sequence against the CnidoSite BLAST databases. The query is filled in and the species’ database is preselected — press Run to start. | template found | open → |
| Expression heatmap | Draw this gene’s expression as a heatmap across all RNA-seq samples, and compare it with the genes you add next to it. | ready | open → |
| Gene family / orthogroup | Look this gene up in the single-copy orthogroups built from the high-quality cnidarian genomes, and see which other species carry an orthologue. | open → | |
| Gene set analysis | Start a gene-set enrichment analysis with this gene as the seed list. Add more genes on that page before running it. | open → |